ID G1N216_MELGA Unreviewed; 539 AA.
AC G1N216;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Cdc42 guanine nucleotide exchange factor 9 {ECO:0000313|Ensembl:ENSMGAP00000005625.3};
GN Name=ARHGEF9 {ECO:0000313|Ensembl:ENSMGAP00000005625.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000005625.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000005625.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000005625.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1N216; -.
DR Ensembl; ENSMGAT00000006365.3; ENSMGAP00000005625.3; ENSMGAG00000005674.3.
DR GeneTree; ENSGT00940000154103; -.
DR HOGENOM; CLU_008436_2_1_1; -.
DR TreeFam; TF316832; -.
DR Proteomes; UP000001645; Chromosome 9.
DR Bgee; ENSMGAG00000005674; Expressed in brain and 18 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 131..315
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 346..453
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 63573 MW; 9C681E2BE1CAC479 CRC64;
MTHRYPSQAT SHPSQPSPRA PPFKVLVERC RSEPLSQSTP MGLDQVGGRM QHLLRRRAEN
ELASKTLKVR RNGGRRWNLL KPGAEKLQIS RLWVNQEDGV EEGTSEVQNG HLDPSADCLC
LGRTVQNRDQ MRANVINEIM STERHYIKHL KDICEGYLKQ CRKRRDMFSD EQLKIIFGNI
EDIYRFQMGF VRDLEKQYNN EDPHLSEIGP CFLEHQDGFW IYSEYCNNHL DACMELSKLM
KDSRYQHFFE ACRLLQQMID IAIDGFLLTP VQKICKYPLQ LAELLKYTAQ DHSDYRYVAA
ALAVMRNVTL QINERKRRLE NIDKIAQWQA SVLDWEGDDI LDRSSELIYT GEMSWIYQPY
GRNQQRVFFL FDHQMVLCKK DLIRRDILYY KGRIDMDKYE VVDIEDGRDD DFNVSMKNAF
KLHNKETEEM HLFFAKKLEE KLRWLRAFRE ERKMVKEDEK IGFEISENQK RQAAMTVKKV
SKQKGVSYSK SVPPAYPPPQ DPLNQGQYMV TDGISQSQVF EFTEPRRSQA PFWQNFSRE
//
