ID G1N5M2_MELGA Unreviewed; 442 AA.
AC G1N5M2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Ectonucleoside triphosphate diphosphohydrolase 6 {ECO:0008006|Google:ProtNLM};
GN Name=ENTPD6 {ECO:0000313|Ensembl:ENSMGAP00000007268.1};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000007268.1, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000007268.1, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000007268.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR RefSeq; XP_003203840.2; XM_003203792.3.
DR AlphaFoldDB; G1N5M2; -.
DR Ensembl; ENSMGAT00000008037.2; ENSMGAP00000007268.1; ENSMGAG00000007154.3.
DR GeneID; 100541241; -.
DR KEGG; mgp:100541241; -.
DR CTD; 955; -.
DR GeneTree; ENSGT01100000263540; -.
DR HOGENOM; CLU_010246_0_2_1; -.
DR InParanoid; G1N5M2; -.
DR OMA; VVYIKWH; -.
DR OrthoDB; 180318at2759; -.
DR TreeFam; TF315029; -.
DR Proteomes; UP000001645; Chromosome 2.
DR Bgee; ENSMGAG00000007154; Expressed in hindlimb stylopod and 17 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF99; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT ACT_SITE 185
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 215..219
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 442 AA; 49036 MW; 1410154E83A2A7C1 CRC64;
MEAMKISKRF FAFGILACIA FYVAYMKWHL DSKALVGATE GIAESTGDKV NRQALTSDLS
VFYGIMFDAG STGTRIHIFK FTQQPKETPK LTHETFKALK PGLSAYADDV EKSGQGIREL
LEVAKKEVPM ELWKFTPLVL KATAGLRLLP GEKAQKLLNK VKEIFQASPF FVRDNCVSIM
NGTDEGISAW ITINFLTGSL DDPQKRSVGM LDLGGGSTQI TFLPRTEATL QASPAGHTTS
FQMFNSTYKL YSYSYLGLGL MSARLAILGG VEGKPLGEGE ELISPCLPPG FKSEWQHAEI
LYKIKGQKAG EPLYESCSNK VAKMLYKKVH KAEEVKDLDF YAFSYYYDCA AEVGLIDKEK
GGSLTANDFE VAAKYVCKTM EISPGSSPFL CMDLTYITFL LQELGFPKSQ VFKLARKINN
VETSWALGAT FHYIDSLNRL QY
//
