ID G1N5M9_MELGA Unreviewed; 906 AA.
AC G1N5M9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Dynamin-like 120 kDa protein, mitochondrial {ECO:0000256|ARBA:ARBA00018307};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN Name=OPA1 {ECO:0000313|Ensembl:ENSMGAP00000007276.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000007276.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000007276.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000007276.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001837};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004325}.
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DR AlphaFoldDB; G1N5M9; -.
DR Ensembl; ENSMGAT00000008045.3; ENSMGAP00000007276.3; ENSMGAG00000007136.3.
DR GeneTree; ENSGT00550000074851; -.
DR Proteomes; UP000001645; Chromosome 11.
DR Bgee; ENSMGAG00000007136; Expressed in pancreas and 17 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR045817; OPA1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF67; DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF19434; OPA1_C; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 245..521
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 168..213
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 906 AA; 105465 MW; 0A7B849A568D8E3A CRC64;
PLQNLHLVSR SIHHPYHPSL KFQRRPLRIS LQQFSSLNRL PLRKTKLLNV KYGYQSYRNF
WLARLASRLL KIRYLILGSA VGGGYTAKKT YDQWKDMMPD LDEYKWIIPD FIWELDEHID
LEKLIKALPD ADDLAKLLPD FEKIGESFTS LKGIFSPGEN NFSAYEQRVS DKEKIDQLQE
ELLRTQLKYQ RMLERLEKEN KELRKLVLQR DDKGIHQRKL KKSLIDMYSE VLDILSDYDA
SYNTQDHLPR VVVVGDQSAG KTSVLEMIAQ ARIFPRGSGE MMTRSPVKVT LSEGPHHVAL
FKDSSREFDL TKEEDLAALR NEIEIRMRNS VKEGCTVSTE TISLSVKGPG LQRMVLVDLP
GVISTVTSGM APDTKETIFS ISKAYMQNPN AIILCIQDGS VDAERSIVTD LVSQMDPQGK
RTIFVLTKVD LAEKNVASPS RIQQIIEGKL FPMKALGYFA VVTGKGNSSE SIESIKEYEE
EFFQNSKLLK TCMLKAHQVT TKNLSLAVSD CFWKMVRESV EQQADAFKAT RFNLETEWKN
NYPRLRELDR NELFEKAKNE ILDEVISLTQ VTPKHWEEIL QKTLWERVST HVIENIYLPA
AQTMNSGTFN TTVDIKLKQW TDKQLPNKAV EVAWETLQEE FSRFMTEQKG KEHDDIFDKL
KQAVKEESIK RHKWNERAED SLRVIQHNAL EDRSISDKQQ WDAAIHFMEE TLQSRLKDTE
SVIEDMVGPD WKKRWLYWIG RTKEQNIRNE TKNELEKLIK CNEEHAAYLA NDEVTTVRKN
LEARGITVDP CLIKDTWHQI YRRYFLKTAL NHCNLCRRGF YYYQRHFVDS ELECNDIVLF
WRIQRMLAIT ANTLRQQLTN TEGKAHSELF EIKKMFYKEV PQGARLILKS LKAFNFFFPN
NLATSK
//
