ID G1N708_MELGA Unreviewed; 484 AA.
AC G1N708;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=CASP8 and FADD like apoptosis regulator {ECO:0000313|Ensembl:ENSMGAP00000007945.1};
GN Name=CFLAR {ECO:0000313|Ensembl:ENSMGAP00000007945.1};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000007945.1, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000007945.1, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000007945.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134}.
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DR RefSeq; XP_010711730.1; XM_010713428.2.
DR RefSeq; XP_010711732.1; XM_010713430.2.
DR RefSeq; XP_019472549.1; XM_019617004.1.
DR AlphaFoldDB; G1N708; -.
DR MEROPS; C14.971; -.
DR Ensembl; ENSMGAT00000008734.2; ENSMGAP00000007945.1; ENSMGAG00000007778.2.
DR GeneID; 100549881; -.
DR KEGG; mgp:100549881; -.
DR CTD; 8837; -.
DR GeneTree; ENSGT00530000064199; -.
DR HOGENOM; CLU_036904_4_3_1; -.
DR InParanoid; G1N708; -.
DR OMA; NCFRSIH; -.
DR OrthoDB; 2873736at2759; -.
DR TreeFam; TF352765; -.
DR Proteomes; UP000001645; Chromosome 7.
DR Bgee; ENSMGAG00000007778; Expressed in liver and 17 other cell types or tissues.
DR GO; GO:0031264; C:death-inducing signaling complex; IEA:Ensembl.
DR GO; GO:0097342; C:ripoptosome; IEA:Ensembl.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0008047; F:enzyme activator activity; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0060544; P:regulation of necroptotic process; IEA:Ensembl.
DR CDD; cd08337; DED_c-FLIP_r1; 1.
DR CDD; cd08340; DED_c-FLIP_r2; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF4; CASP8 AND FADD LIKE APOPTOSIS REGULATOR; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..78
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 97..175
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 267..363
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
SQ SEQUENCE 484 AA; 55959 MW; 2E62A79F21A6A8C2 CRC64;
MTKCEVPAIL IHQIEEELDK EEDEMMIFLC RDLAPDLATA GLRELLVALN ERDKLSFLGL
SELLYRVKRF DLLRRILKTE KTTVEANLSR NPRLVPDYRV LMVEINENLE KEEVSSLAFL
LKDFTPRMKM AKDKSFLRLV IELEKLNLVA PNQLDLMENC FRNIHRIDLV KKIEKYKQEA
FMSSVRSQPV YVNALQASLP NLSLIDPPYN SGFQNMNKEK SQNGEISFQE EPVHMSIQES
GPASHKVYRM QSHPLGVCLI IDCVGNDTDM LEDTFRGLDY DVHCHQHLDM STMSRTLVEV
ARLQKHRSCD SFICILVSRG NAQNIFCTDS ISTGFPLEQI KKYFTADSCP ELRGKPKLFF
IQSYIVPEDE QEFTSLEIDG NDKKIISNAK MPLKDTIPQV ADVFWSQCKV DVSTLEKSPK
QSSYYLRCLA ELLRNPHKRK LSILDIHTEL NRRVYEWNKT TDPSQQYSLL LQHTLRKTLF
LSPS
//
