ID G1N743_MELGA Unreviewed; 499 AA.
AC G1N743;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Bactericidal permeability-increasing protein {ECO:0000256|ARBA:ARBA00017827, ECO:0000256|RuleBase:RU369039};
DE Short=BPI {ECO:0000256|RuleBase:RU369039};
GN Name=LOC100546675 {ECO:0000313|Ensembl:ENSMGAP00000007994.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000007994.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000007994.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000007994.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The cytotoxic action of BPI is limited to many species of
CC Gram-negative bacteria; this specificity may be explained by a strong
CC affinity of the very basic N-terminal half for the negatively charged
CC lipopolysaccharides that are unique to the Gram-negative bacterial
CC outer envelope. {ECO:0000256|RuleBase:RU369039}.
CC -!- SUBUNIT: Monomer. Homodimer; disulfide-linked.
CC {ECO:0000256|ARBA:ARBA00025943, ECO:0000256|RuleBase:RU369039}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU369039}.
CC -!- DOMAIN: The N- and C-terminal barrels adopt an identical fold despite
CC having only 13% of conserved residues. {ECO:0000256|RuleBase:RU369039}.
CC -!- DOMAIN: The N-terminal region may be exposed to the interior of the
CC granule, whereas the C-terminal portion may be embedded in the
CC membrane. During phagocytosis and degranulation, proteases may be
CC released and activated and cleave BPI at the junction of the N- and C-
CC terminal portions of the molecule, providing controlled release of the
CC N-terminal antibacterial fragment when bacteria are ingested.
CC {ECO:0000256|RuleBase:RU369039}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000256|ARBA:ARBA00007292}.
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DR AlphaFoldDB; G1N743; -.
DR Ensembl; ENSMGAT00000008783.2; ENSMGAP00000007994.2; ENSMGAG00000007751.2.
DR GeneTree; ENSGT01100000263545; -.
DR HOGENOM; CLU_028970_3_2_1; -.
DR InParanoid; G1N743; -.
DR TreeFam; TF315617; -.
DR Proteomes; UP000001645; Chromosome 22.
DR Bgee; ENSMGAG00000007751; Expressed in liver and 17 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR CDD; cd00025; BPI1; 1.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR032942; BPI/LBP/Plunc.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR10504; BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED; 1.
DR PANTHER; PTHR10504:SF84; BACTERICIDAL PERMEABILITY-INCREASING PROTEIN; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR SMART; SM00328; BPI1; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
PE 3: Inferred from homology;
KW Antibiotic {ECO:0000256|ARBA:ARBA00023022, ECO:0000256|RuleBase:RU369039};
KW Antimicrobial {ECO:0000256|ARBA:ARBA00022529,
KW ECO:0000256|RuleBase:RU369039};
KW Disulfide bond {ECO:0000256|RuleBase:RU369039};
KW Glycoprotein {ECO:0000256|RuleBase:RU369039};
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|RuleBase:RU369039};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|RuleBase:RU369039};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Secreted {ECO:0000256|RuleBase:RU369039};
KW Signal {ECO:0000256|RuleBase:RU369039}.
FT DOMAIN 47..270
FT /note="Lipid-binding serum glycoprotein N-terminal"
FT /evidence="ECO:0000259|SMART:SM00328"
FT DOMAIN 285..498
FT /note="Lipid-binding serum glycoprotein C-terminal"
FT /evidence="ECO:0000259|SMART:SM00329"
FT REGION 419..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 53013 MW; E838846C1D6B9C73 CRC64;
MGAGGGRTGR ERRAAAGMAA RSLAAFGAVL AVCLALTAAT NPGFVVRITQ AGLDYAHQHG
ITVLQKELAK LKLPDISGDF PVRRLGKVRY EISSLDLRSF HLPYSRISLV PNVGLQVAIS
NAFAEVDGNW RVKFHFIRDH GSFNLEVKNV YIKIDLKLGN DASGKPTVST SACSTRISSV
DVHFSGKFGW LYNLFYSAVE SRFKKILESK VCDSVVRSVG GDLQHYLQTL PVTAKIDARA
GIDYSLVAPP MATAQTLDVD LKGEFFSLAH RGAVPFPPPV LALPPDHDRM VYFGASSYFF
NTAGFAYHAA GALVYEITDS MIPKGVEFHL NTSTFAAFIP QLDEMYPNML MKLRLSAPSA
PFLSITPGGI SLQPVVDIQA YAILPNTSLA HLFLLSLTGN VSATIDVKSG HIVGKLTVGS
RGRCPPAPPS PGSCRQSGPE PSAMSASPPA GHGAPESCGT ARVLSPQGQP GAGERGPHAP
VALSAQCSSS CVPLQLRCV
//
