ID G1N801_MELGA Unreviewed; 363 AA.
AC G1N801;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Divergent protein kinase domain 1C {ECO:0000313|Ensembl:ENSMGAP00000008380.3};
GN Name=DIPK1C {ECO:0000313|Ensembl:ENSMGAP00000008380.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000008380.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000008380.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000008380.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the DIPK family.
CC {ECO:0000256|ARBA:ARBA00006338}.
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DR RefSeq; XP_010706995.1; XM_010708693.2.
DR AlphaFoldDB; G1N801; -.
DR Ensembl; ENSMGAT00000009176.3; ENSMGAP00000008380.3; ENSMGAG00000008201.3.
DR GeneID; 100541504; -.
DR KEGG; mgp:100541504; -.
DR CTD; 125704; -.
DR GeneTree; ENSGT00390000006452; -.
DR HOGENOM; CLU_042490_0_0_1; -.
DR InParanoid; G1N801; -.
DR TreeFam; TF313319; -.
DR Proteomes; UP000001645; Chromosome 3.
DR Bgee; ENSMGAG00000008201; Expressed in breast and 8 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR InterPro; IPR029244; FAM69_N.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR21093:SF2; DIVERGENT PROTEIN KINASE DOMAIN 1C; 1.
DR PANTHER; PTHR21093; UNCHARACTERIZED; 1.
DR Pfam; PF12260; PIP49_C; 1.
DR Pfam; PF14875; PIP49_N; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 10..104
FT /note="FAM69 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14875"
FT DOMAIN 129..329
FT /note="FAM69 protein-kinase"
FT /evidence="ECO:0000259|Pfam:PF12260"
SQ SEQUENCE 363 AA; 41533 MW; DC519FB4BC003EB3 CRC64;
MNMNVPSLSI QCLDYSSGAL TGDLCEDLCV AQKLVYKHCL YYDRGKKVIQ ADWRGQPIIL
KSKKEIFSSY QHLSVLDEVE TQDIPETEIL LMVALEVKNV LGLELSNNST GPLWTRRKGP
HWKAQVASMW SLIQQEEYIF FSLLQDFSKH VLRIIGSCGH FYAVEYLTAG HAWHKTLFPL
ENIVGSSLAG RKSSVGAIID IALSFLDMVQ HFDNDFSHRL HLCDIKPENF AIRHDLTVVA
IDVDMAFFEP KMRDILEQNC TGDEDCNFFD CFSKCNLKIR RCGAQRANNN LQVICDKIFR
RWFSPSLRGP LVSFPLQPQL QKAVQECAEL GHVDATVHQR TLNSLIELYH LLRVSQQELQ
RVE
//
