ID G1N8Z2_MELGA Unreviewed; 1344 AA.
AC G1N8Z2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=FA complementation group I {ECO:0000313|Ensembl:ENSMGAP00000008831.2};
GN Name=FANCI {ECO:0000313|Ensembl:ENSMGAP00000008831.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000008831.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000008831.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000008831.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSMGAT00000009636.2; ENSMGAP00000008831.2; ENSMGAG00000008560.2.
DR GeneTree; ENSGT00390000005855; -.
DR HOGENOM; CLU_004843_1_0_1; -.
DR InParanoid; G1N8Z2; -.
DR TreeFam; TF323694; -.
DR Proteomes; UP000001645; Chromosome 12.
DR Bgee; ENSMGAG00000008560; Expressed in bursa of Fabricius and 16 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1990391; C:DNA repair complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0070182; F:DNA polymerase binding; IEA:Ensembl.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR CDD; cd11720; FANCI; 1.
DR InterPro; IPR026171; FANCI.
DR InterPro; IPR029310; FANCI_HD1.
DR InterPro; IPR029312; FANCI_HD2.
DR InterPro; IPR029308; FANCI_S1.
DR InterPro; IPR029305; FANCI_S1-cap.
DR InterPro; IPR029315; FANCI_S2.
DR InterPro; IPR029313; FANCI_S3.
DR InterPro; IPR029314; FANCI_S4.
DR PANTHER; PTHR21818; BC025462 PROTEIN; 1.
DR PANTHER; PTHR21818:SF0; FANCONI ANEMIA GROUP I PROTEIN; 1.
DR Pfam; PF14679; FANCI_HD1; 1.
DR Pfam; PF14680; FANCI_HD2; 1.
DR Pfam; PF14675; FANCI_S1; 1.
DR Pfam; PF14674; FANCI_S1-cap; 1.
DR Pfam; PF14676; FANCI_S2; 1.
DR Pfam; PF14677; FANCI_S3; 1.
DR Pfam; PF14678; FANCI_S4; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 1..53
FT /note="FANCI solenoid 1 cap"
FT /evidence="ECO:0000259|Pfam:PF14674"
FT DOMAIN 64..281
FT /note="FANCI solenoid 1"
FT /evidence="ECO:0000259|Pfam:PF14675"
FT DOMAIN 287..372
FT /note="FANCI helical"
FT /evidence="ECO:0000259|Pfam:PF14679"
FT DOMAIN 380..543
FT /note="FANCI solenoid 2"
FT /evidence="ECO:0000259|Pfam:PF14676"
FT DOMAIN 557..788
FT /note="FANCI helical"
FT /evidence="ECO:0000259|Pfam:PF14680"
FT DOMAIN 806..1030
FT /note="FANCI solenoid 3"
FT /evidence="ECO:0000259|Pfam:PF14677"
FT DOMAIN 1043..1295
FT /note="FANCI solenoid 4"
FT /evidence="ECO:0000259|Pfam:PF14678"
SQ SEQUENCE 1344 AA; 149767 MW; 16A7017D9182F400 CRC64;
MAQRILQLAA EESPERLQEA LQGLAEGELG DMVTRQALRG RETAALLRGI FRGSPCSQQS
GVLRRLQVYK HCVPLVESGD LHVGKVSEII GLLMLEARQL PGHALAELAT LFVEVIKGGS
LSNGKSLELF STVLTALSNS KESLAYGKGE LNGEEFKKQL INTLCSSKWD PQCVIHLANM
FRDIPLSGEE LQFVVEKVLR MFSKLDLQEI PPLVYQLLLL SAKGSKKTVL EGIISFFNQL
DKRQKEEQRV PQSADLEVAT LPLDQLRHVE GTVILHIVSA ISLDQDIGEE LIKHLKTEQQ
KDPGKALCPF SVALLLSIAV KHRLQEQIFD FLKTSITRSC KDLQFLQASK FLQDLCPQQY
DVTAVILEVV KNSAFGWDHV TQGLVDLGFS LMESYEPKKS FGGKAAETNL GLSKMPAQQA
CKLGASILLE TFKVHEPIRS DILEQVLNRV LTKAASPVSH FIDLLSNIVV SAPLVLQNSS
SRVTETFDNL SFLPIDTVQG LLRAVQPLLK VSMSVRDSLI LVLQKAIFSR QLDARKAAVA
GFLLLLRNFK ILGSLTSSQC SQAIGATQVQ ADVHACYNSA ANEAFCLEIL GSLRRCLSQQ
ADVRLMLYEG FYDVLRRNSQ LTSSIMETLL SQIKQYYLPQ PDLLPPLKLE GCIMAQGDQI
FLQEPLAHLL CCIQHCLAWY KSTVHLCKGG EDEEEEDVGF EQRFEEMLES VTRRMIKSEL
EDFELDKSAD FSPSSGVGVK NNIYAIQVMG ICEVLIEYNF NTGNFSKNRF EDVLGLFTCY
SKLSEILKEK TGKNKSALGN KIARSFLSMG FVSTLLTALF RDNAQSHEES LAVLRCSTEF
LRYAVSVALQ KVQQLEETGQ TDGPDGQNPE KVFQNLCKIT RVLLWRYTSI PTAVEESGKK
KGKSISLLCL EGLLRIFNTM QQLYTARIPQ FLQALDITDG DAEEADINVT EKAAFQIRQF
QRSLVNQLSS SEDDFNSKET QLLITILSTL SKLLDPGSQQ FLQFLTWTVK ICKENALEDL
SCCKGLLTLL FSLHVLYKSP VSLLRELAQD IHACLGDIDQ DVEIESRSHF AIVNVKTAAP
TVCLLVLGQA DKVLEEVDWL IKRLTILGSD TSEDSTQASN QTQALEKGVI LQLGTLLTVF
HELVQTALPA GSCVDSLLRS LSKTYTILTS LIKHYIQACR STSNTVPGRL EKLVKLSGSH
LTPQCYSFIT YVQNIHSESL SFAEEKKKKK KEDETAAVST VMAKVLRETK PIPNLIFAIE
QYEKFLIHLS KKSKVNLMQY MKLSTSRDFR INASLLDSVL QEHNTEDAEN EPDNNQCWEC
KKQHQEEAGN EDCSPLKLAA VHSS
//
