ID G1N9W5_MELGA Unreviewed; 768 AA.
AC G1N9W5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=HHIP like 2 {ECO:0000313|Ensembl:ENSMGAP00000009254.2};
GN Name=HHIPL2 {ECO:0000313|Ensembl:ENSMGAP00000009254.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000009254.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000009254.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000009254.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the HHIP family.
CC {ECO:0000256|ARBA:ARBA00010658}.
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DR RefSeq; XP_010704981.1; XM_010706679.2.
DR AlphaFoldDB; G1N9W5; -.
DR Ensembl; ENSMGAT00000010071.2; ENSMGAP00000009254.2; ENSMGAG00000008982.2.
DR GeneID; 100548944; -.
DR KEGG; mgp:100548944; -.
DR CTD; 79802; -.
DR GeneTree; ENSGT00940000161139; -.
DR HOGENOM; CLU_012344_2_1_1; -.
DR TreeFam; TF329059; -.
DR Proteomes; UP000001645; Chromosome 2.
DR Bgee; ENSMGAG00000008982; Expressed in ovary and 10 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR018143; Folate_rcpt-like.
DR InterPro; IPR012938; Glc/Sorbosone_DH.
DR InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR PANTHER; PTHR19328; HEDGEHOG-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR19328:SF54; HHIP-LIKE PROTEIN 2; 1.
DR Pfam; PF03024; Folate_rec; 1.
DR Pfam; PF07995; GSDH; 1.
DR SUPFAM; SSF50952; Soluble quinoprotein glucose dehydrogenase; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 75..211
FT /note="Folate receptor-like"
FT /evidence="ECO:0000259|Pfam:PF03024"
FT DOMAIN 235..561
FT /note="Glucose/Sorbosone dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF07995"
FT REGION 653..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..768
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 86358 MW; 19FFA3F4955CF702 CRC64;
MNEPEVQDFH TSDLRKLTLK KVNVWPGTGR RSGGSKASFS CPHVFLCLSL FCWVGSLLGH
PQCLDYGPPF QPPFHLEFCS AYENFGCCDR ERDNSIAAKY HEILDYIDPR GHKLCGTYIK
DILCQECSPY AAHLYDAENP RTPLRYLPGL CFDYCSEFHF NCRSAISLLT SDKHIQECCE
TNKTRFCNLL RLHDEDYCFP NVLRNTALNR NLGSVVEDRR GCLQLCLTEV ANGLRNPVLM
LHANDRTHRM FVAEQVGVIW VYLPDGSRLE EPFLDIKSIV LATPWIGDER GFLGMAFHPN
YKNNGKFYIY YSYMDKKQVE KIRISELKVL ASDANKADPH SERNLLELEE PAANHNGGQL
LFGVDGYLYL FIGDGGKAGD PFGKFGNAQN KSVLLGKVLR IDVDGRSPDG KPYRIPPDNP
FVSDLKARPE VYAYGVRNMW RCAVDRGDPV TKKGRGRIFC GDVGQNRFEE VDIIVKGGNY
GWRAKEGFEC YDTKLCHNSS LDDILPIFAY GRNVGKSVTG GYVYRGCESP NLNGLYIFGD
FMNGRLMALR EDEKTNRWKN QDICIGSTKA CAFPGMIRSY NKFIISFAED EAGELYFMST
SYPSAYAPHG SLYKFVDPAR RAPPGKCKYK PVTVKIKSKR IAFVPRAKTV LDFLNEPSPT
KPPKRSSTPP GATPPASSKK SKKMASSKIK ASTVKPALSN KKTLKTEAGG EHHKPKQKQQ
KVARASRTTP APSLPKRKSS QLTEAKKLLP KKAAQAKEKL GRRRKESR
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