ID G1NAS0_MELGA Unreviewed; 865 AA.
AC G1NAS0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Nuclear factor of activated T cells 2 {ECO:0000313|Ensembl:ENSMGAP00000009648.2};
GN Name=NFATC2 {ECO:0000313|Ensembl:ENSMGAP00000009648.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000009648.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000009648.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000009648.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019477835.1; XM_019622290.1.
DR AlphaFoldDB; G1NAS0; -.
DR Ensembl; ENSMGAT00000010479.2; ENSMGAP00000009648.2; ENSMGAG00000009346.2.
DR GeneTree; ENSGT00940000156230; -.
DR HOGENOM; CLU_010185_1_1_1; -.
DR InParanoid; G1NAS0; -.
DR TreeFam; TF326480; -.
DR Proteomes; UP000001645; Chromosome 22.
DR Bgee; ENSMGAG00000009346; Expressed in spleen and 10 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:Ensembl.
DR GO; GO:0035976; C:transcription factor AP-1 complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0014904; P:myotube cell development; IEA:Ensembl.
DR GO; GO:0098781; P:ncRNA transcription; IEA:Ensembl.
DR GO; GO:1905064; P:negative regulation of vascular associated smooth muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF4; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 302..484
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 94835 MW; 0104787F4E11D116 CRC64;
MGRYGQPDSI GTAPTHPASA AGASAPSPRI EITSYPELIN SGGPFRSRDT NVLLVEHQSN
SATTSPRVTL PVPGFEGYRE PLCLSPASSG SSASFISETN LSPCTSPCVS PNNGPSDDLC
PQFQNIHTHY SPRTSPIMSP RTSITEETCL GQHSPSPRPN SRSSSPGAKR RYSCTQQPST
SPRQSRTPSP QSSPRIPLRE DSSTLTYTQL SSAPLSMDAM NSLPTDPSCG VPTKIWKTSP
DPSSMPSHKN SIPCHVFQTV DFHGPCEQED RRNSAPESIL LVPPSWTKQL MPAIPICSLP
VQSLPPLEWP LSSQSGSYEL RIEVQPKPHH RAHYETEGSR GAVKAPTGGH PVVQLHGYME
NKPLGLQIFI GTADERILKP HAFYQVHRIT GKTVTTTSYE KIIGNTKVLE IPLEPKNNMK
ATIDCAGILK LRNADIELRK GETDIGRKNT RVRLVFRVHI PESSGRIISL QAASNPIECS
QRSAHELPMV ERQDIDSCLV YGGQQMILTG QNFTAESKVV FTEKTSDGQQ IWEMEATVDK
DKSQPSMLFV EIPEYRNKHI RTPVKVNFYV INGKRKRSQP QHFTYHPVPS IKTEPIDDYD
PALICNTVHS GLGTVTQPYY SQHTMVTESP SCLVATMAPC QQLRSGLSSP DSRYHPQNPA
AVVYQRSKSL SPSQLGYQQS GLMATPVAIS DAHRSVLVHA GSPGQTSAVL HHSPGNQQSS
PVIHYSPTNQ QLRCGSHQEF QHIMCCENFT SSVARPSQPQ VSQAQRLSPS SYPTVIQQQT
ASGQRGAKNG QPVSDQKEVL PAGVTIKQEQ NLDQAYLDDD FLFSAGTLQH SQGTACFILG
LLLLCLCRIR TEVLQSHARV LLYWV
//
