ID G1NBG1_MELGA Unreviewed; 821 AA.
AC G1NBG1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000009964.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000009964.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000009964.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; G1NBG1; -.
DR Ensembl; ENSMGAT00000010808.3; ENSMGAP00000009964.3; ENSMGAG00000009615.3.
DR GeneTree; ENSGT00940000158969; -.
DR HOGENOM; CLU_006685_1_3_1; -.
DR InParanoid; G1NBG1; -.
DR TreeFam; TF314265; -.
DR Proteomes; UP000001645; Chromosome 1.
DR Bgee; ENSMGAG00000009615; Expressed in pectoralis major and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF21; ANOCTAMIN-6; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 209..236
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 371..398
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 418..439
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 466..484
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 582..605
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 633..657
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 736..759
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 7..195
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 198..781
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 821 AA; 95439 MW; 05BE66D0E76AFB04 CRC64;
MGSIHVKRKR QVYESNLINN GLQLEATRSV LDEKTIFVKV HAPWEVLCTY AEVMHIKLPL
QPNDLKTRES AFNWFTRLFS VDENIIKPEQ EFFTAPFKRE HLSNFYIQDK DAFFNPATRS
RIVHFILSRV KYATKQNLKK FGINKLLDTG IYKAAFPLHD SSFGHLSTDP NCPSERYLLY
REWAHPKNIL KLQPLDFIRK YYGEKIGIYF AWLGFYTNML VVAAVVGVGC FLYGFFMKDS
CTWSQEVCDP NIGGNIIMCP QCDKVCTYWN LTITCESSKK LCIFDSFGTL VFAVFMGIWV
TLFLEFWKRR QAELEYEWDT VEYLEQEEQI RPEYEAQCTH VVVNEITQQE EHVPYTACGK
CVRITLCTSA VFFWILLIIA SVIGIIVYRL SVFLVFSATL PRNINGTQTI RKYLTPQTAT
SVTASIISFI IIMVLNIVYE KVAILITDFE LPRTQTEYEN SLTTKMFLFQ FVNYYSSCFY
IAFFKGKFVG YPGNPVYWLG KYRNEECDPG GCLLELTTQL AIIVGGKAIW NNIQEVLLPW
VKNLIGRYCA DARSEKIVPR WEQDYHLQPI GKLGLFYEYL EMVIQFGFVT LFVASFPLAP
LLALINNMLE IRLDAWKLTT QFRRMVPQKA QDIGAWQPIM QGIAILAVVT NAMIIAFTSD
MIPRLVYYWS FSVPPYGSHS SYTMKGYINN TLSVFNISDF KNASKPFSSW FENHTTCRYR
DFRYPPGHQH QYEHNIYYWH VIAAKLAFII VMEHVIYFVK FIISYIIPDV SQETKSKVKR
EKYLTQKILH ENDLKVVKKT IGKIADKIIE GVDSTFRPKT E
//
