ID G1NCL6_MELGA Unreviewed; 1220 AA.
AC G1NCL6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=NPC intracellular cholesterol transporter 1 {ECO:0000313|Ensembl:ENSMGAP00000010503.3};
GN Name=NPC1 {ECO:0000313|Ensembl:ENSMGAP00000010503.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000010503.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000010503.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000010503.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR AlphaFoldDB; G1NCL6; -.
DR Ensembl; ENSMGAT00000011362.3; ENSMGAP00000010503.3; ENSMGAG00000010105.3.
DR GeneTree; ENSGT00940000156182; -.
DR HOGENOM; CLU_002359_0_0_1; -.
DR InParanoid; G1NCL6; -.
DR TreeFam; TF300416; -.
DR Proteomes; UP000001645; Chromosome 3.
DR Bgee; ENSMGAG00000010105; Expressed in ovary and 17 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0031902; C:late endosome membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEA:Ensembl.
DR GO; GO:0071383; P:cellular response to steroid hormone stimulus; IEA:Ensembl.
DR GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0010878; P:cholesterol storage; IEA:Ensembl.
DR GO; GO:2000900; P:cyclodextrin metabolic process; IEA:Ensembl.
DR GO; GO:0006897; P:endocytosis; IEA:Ensembl.
DR GO; GO:0090150; P:establishment of protein localization to membrane; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0032367; P:intracellular cholesterol transport; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0016236; P:macroautophagy; IEA:Ensembl.
DR GO; GO:0031579; P:membrane raft organization; IEA:Ensembl.
DR GO; GO:0016242; P:negative regulation of macroautophagy; IEA:Ensembl.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:Ensembl.
DR GO; GO:0022008; P:neurogenesis; IEA:Ensembl.
DR GO; GO:0012501; P:programmed cell death; IEA:Ensembl.
DR GO; GO:0006486; P:protein glycosylation; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0016125; P:sterol metabolic process; IEA:Ensembl.
DR GO; GO:0046718; P:viral entry into host cell; IEA:Ensembl.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 202..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 670..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1040..1059
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1066..1087
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1093..1111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1132..1158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1170..1193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 563..728
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1220 AA; 136265 MW; 2679FA7FD7E56202 CRC64;
MQELCPGLFF GNVSTCCDIL QLQTLKNNLQ LPLQFLSRCP SCFYNLINLF CELTCSPNQS
EFLNVTSTIP YYDPVSKENK SSITELQYFI GERFANEMYN ACKDVEAPSS NVKALGLLCG
KDAKDCNATN WIEYMFSKDN GQTPFSIIPI FSDVPVHGMN PMNNATKGCN ESVDDSTGPC
SCQDCSIVCG PKPQPPPLPV PWLLFGLDAV YIIMWISYMG FLLVFFALVF GVWCYRRRHF
VSEYTPIDSN VAFSVNSHHD NGKITCGERL GERFENGLRM TFTSWGAFCV RNPRPVILFS
VVFIAMCCSG FVYIKATTNP VDLWSAPSSQ ARKEKEYFDK HFGPFFRTEQ LIIQAPNSRP
SIYSPYPSGA DVPFGPPLDK DILHQVLDLQ NAIVNIVASF DNETVMLKDI CVAPLAPYNN
NCTILSVLNY FQNSHSVLDH AVGDEFFVYA DYHTHFLYCV RAPASLNDTS LLHDPCLGAF
GGPVFPWLVL GGYDGDNYNN ATALVITLPV NNYYNDSKKI MKALAWEKEF VNFLKNYNNP
NLTISFSAER SIEDEINRES RSDVSTVLIS YIVMFVYISI ALGHIQSWGR LLVDSKISLG
IAGILIVLSS VACSIGIFSY FGVPVTLIVA EVIPFLVLAI GVDNIFIIVQ TLQRDERLEG
ETLDKQIGRV LGDVAPSMFL SSFSETVAFF LGTLSTMPAV RTFSLFAGMA VLIDFILQVT
CFVSLLGLDI RRQERNRLDI LCCIKGSEEM RGVQRSESIL FLFFKNLYSP YLLKDWMRPI
VIALFVGVLS FSTAVIHNVE IGLDQSLSMP DDSYIVNYFK QLGKYMHAGP PVYFVLEEGH
NYTSLEGQNM VCGGTGCNND SLVQQVFNAA EIGSYTRIGY APSSWIDDYF DWVKPQSSCC
RVYNTTGQFC NASVTDPSCT RCRPLTQEGK QRPQGEDFMT FLPMFLSDNP NPKCGKGGHA
AYSSAVDLIN NKTDVGATYF MTYHTVLKKS SDYIDAMKKA RNIADNITET MGIKEKNYRV
FPYSVFYVFY EQYLTIVHDA IFNLCISLGS IFLVTAVLLG FEIWAAVVVT VTIAMIIVNM
FGVMWLWGIS LNAVSLVNLV MSCGIAVEFC SHVTRAFTVS TKGSRVERAE EALSHMGSSV
FSGITLTKFG GIVVLAFSKS QIFKIFYFRM YLAMVLLGAT HGLIFLPVLL SYIGPSVNKA
KTRAAQERSR GTERERLLYF
//
