ID G1ND81_MELGA Unreviewed; 1500 AA.
AC G1ND81;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Multiple EGF like domains 6 {ECO:0008006|Google:ProtNLM};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000010778.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000010778.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000010778.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSMGAT00000011643.3; ENSMGAP00000010778.3; ENSMGAG00000010353.3.
DR GeneTree; ENSGT00940000165767; -.
DR HOGENOM; CLU_004998_0_0_1; -.
DR InParanoid; G1ND81; -.
DR TreeFam; TF332598; -.
DR Proteomes; UP000001645; Chromosome 11.
DR Bgee; ENSMGAG00000010353; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 8.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR PANTHER; PTHR24043:SF8; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 4.
DR Pfam; PF00053; Laminin_EGF; 5.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00051; DSL; 2.
DR SMART; SM00181; EGF; 29.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00180; EGF_Lam; 19.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 13.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 10.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 21..102
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 144..184
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 253..293
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 478..514
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 522..557
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 759..789
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 797..833
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 846..876
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1194..1229
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1279..1314
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1371..1401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 504..513
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 547..556
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 779..788
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 823..832
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 866..875
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1219..1228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1304..1313
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1391..1400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1500 AA; 159288 MW; 9D07AD71FC0604B1 CRC64;
AQAWMASSTF QAPSPQPSAF LPNVCPVLEL VLVGHQQPCV QAFSRMVKMW KQGCTGRRWC
MGYERRSGYY TVYKQVYRME HQTVYKCCPG WAQHNSEPGC LHNVNECSTE NGGCQDQCCN
TIGSYHCKCP AGQKLGEDGK SCGDVDECAE VNGGCQQGCI NTHGSFHCRC QTGYRLHSDG
RTCLSEYMLQ DMDICFLLCS CISARFCRLG LFCYPCTSGN GGCSQICQNE RGTAKCECHP
GHYLSTDKKT CLDIDECAEG RARCAHRCVN TLGSFTCACN PGFELGADGK QCYRIEMEIV
DSCQEDNGGC SHGCEHTATG PRCSCHDGYV LSSDGKACTD LDECETGESC CSQFCINYVG
SYECTCRAGF QPSADGCGCD DMDECRLENG NCDHICINSL GSYECACKEG FRLGADQRSC
IGEFLLHPEG LVRAPGLQFR GAPQLLHYVL GAPGEDEDQR GELTLLRFFL SVCLDNTFGN
DCSLSCEDCM NGGRCNSENS GCVCSPGWTG IICNETCSQG TYGDGCASTC TCQNGGSCDP
ITGLCHCPPG VQGPFCEDGC PKGFFGKNCN KPCHCANSGH CHRLYGACLC DPGLYGRFCH
LTCPRWAFGV GCSQECQCVK EHTLGCSAQN GTCSCKPGYH GKKCQKACTP GFYGAGCKLR
CNCSTDVLCD HETGACKHPC PPGFHGEKCH SSCQPGSFGV DCSQSCSCGG AHCDPETGRC
ICPAGKTGAM CVRDTFHVKL QLAPLLSACP VGYYGQNCLL PCSCSNDALC HHITGECMCP
PGWTGHDCKH PCNSGHWGQR CENSCACNNS DGSCDPVTGS CFCEPGFTGK HCEQRCPEGS
FGPSCMHSCQ CQNGAACDHV SGACMCSAGW TGTFCEKACP EGFFGLDCHQ VCNCKNAAGC
DHVLGTCSCL PGWRGETCEQ PLPPLTDVFG QGCAHTCNCH NGAICDHVTG TCACTPGWEG
ATSCPQGWHG AGCLQRCICP GQTACDPVTG ECQCPKGRTG TSCELGRYGV GCSQNCCSHN
ALGRSDRPDL ITHHHALNKQ HTVPAAAPTL ALCLLLPTAC PPGYFGERCE EQCDCIHSVS
CHPQTGACRC AKGWRGRHCD KPCLPGHYGV GCARRCRCPA GIPCHHLTGE CGCPPGFTGH
GCERTCPPNT YGQSCSQTCR CRAEEDCHPI TGQCVCHPGY HGAQCDRRCP KGTYGSNCQK
SCKCMNGGHC DPVSGTCDCA PGFIGADCSK TCPENRYGKD CALFCACGKG QCDPRTGSCT
CPPGQMGPGC QQVCPQGRFG PSCRLTCSCQ NGAICDHVDG SCTCGLGWTG KSCEKAECLP
GKYGPSCSLD CSCQHNSTCD RFTGCCHCPA GFYGRSCEHG CPPGFYGLSC LHACACKNGA
SCDAVMGQCV CPSGYHGIHC EKGCASGRFG ERCQHRCDCG GAPCNPATGK CLCPPGKTGD
KCDIGCRSDQ YGPDCSLRCQ CASKSQCNPY NGKCVCPATW MGPTCKEGNT APKRISNIPI
//
