ID G1NEE2_MELGA Unreviewed; 695 AA.
AC G1NEE2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Rho guanine nucleotide exchange factor 26 {ECO:0000313|Ensembl:ENSMGAP00000011290.3};
GN Name=ARHGEF26 {ECO:0000313|Ensembl:ENSMGAP00000011290.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000011290.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000011290.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000011290.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSMGAT00000012161.3; ENSMGAP00000011290.3; ENSMGAG00000010835.3.
DR GeneTree; ENSGT01030000234571; -.
DR HOGENOM; CLU_012820_5_0_1; -.
DR TreeFam; TF316357; -.
DR Proteomes; UP000001645; Chromosome 11.
DR Bgee; ENSMGAG00000010835; Expressed in gizzard and 17 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11938; SH3_ARHGEF16_26; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035797; ARHGEF16/ARHGEF26_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12845:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 263..447
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 479..606
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 613..674
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 110..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 78802 MW; DFBE9BD058C6A949 CRC64;
QPRACTAERG AGSAPVPHIP RLPALSCPGP XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXSPAALK VGTQQIIPRS LASGSKATHK GGGHGTDAGR RVLKARSMVE SPGVPLGADE
ETEGEPDSPG VLRRGLRSTS YRRAVVSGID LDGSANFKKK NRMSQPILKA VVEDKEKFSS
LGRTKKKTLK GQGTFDGEEN AVLYQNYKEK ALDNDSDEES EPREQKSDEK VIFPYKPLRS
TWSQLSVVKK NGLSEAISQE ERKRQEAIFE VISSEHSYLL SLEILIRMFK NSRELSLTMT
KTESHHLFSN ITDVYEASKK FFKELEARHQ NNIFIDDISD IVEKHSSSTF DPYVKYCTNE
VYQQRTLQKL LATNPAFKEV LSRIESHEDC RNLPMISFLI LPMQRVTRLP LLMDTICQKT
PKDSPKYENC KQALKEVSKL VRLCNEGARK MERTEMMYTI NSQLEFKIKP FPLVSSSRWL
VKRGELTAYV EDTGLFSKRT SKQQVYFFLF NDVLIITKKK SEESYNVTDY SLRDQLVVQQ
CDSEDLTSSP MKNTSAMLYS RQSSPVHLFR LSVLSNHAGE KVELLLGTET QSERARWITV
LGQDRDRQST DRTTLTQVEI IRTYTAKQSD ELSLQVADVV LVYQKVNDGW YEGERLRDGE
RGWFPMECAK EITCRATIDK NMERMGRLLG LETNV
//
