ID G1NGP1_MELGA Unreviewed; 996 AA.
AC G1NGP1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO4 {ECO:0000313|Ensembl:ENSMGAP00000012271.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000012271.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000012271.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000012271.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; G1NGP1; -.
DR Ensembl; ENSMGAT00000013160.3; ENSMGAP00000012271.3; ENSMGAG00000011699.3.
DR GeneTree; ENSGT00940000158600; -.
DR HOGENOM; CLU_006685_1_3_1; -.
DR TreeFam; TF314265; -.
DR Proteomes; UP000001645; Chromosome 1.
DR Bgee; ENSMGAG00000011699; Expressed in brain.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF28; ANOCTAMIN-4; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 391..417
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 467..486
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 543..569
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 589..610
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 638..659
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 758..780
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 808..832
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 152..377
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 380..961
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 960..994
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 21..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 996 AA; 115885 MW; 5D772A7E215B3293 CRC64;
MQICQRKTAA SYPVSQRPPV VGHPSLSQVS RSISMEASSA GSSNPTASGG KAKTHQPEGR
EDLQVNRLET QIWIKPDAQK TDVDFSEILN AIEEIAKDVN IFFDELEGVN SPSKDDDSLL
HHGNLTSTSD DASRLEVVGE EVPDKNKANG LYFRDGKCRI DYILVYRKSN PQTEKREVFE
RNIRAEGIQM EKESSLTNSD IIFVKLHAPW EVLGKYAELM NVRMPFRRKI YYLHRRYKFM
NRIEKQISRF RGWLPRKPMK LDKETLPDLE ENDCYTAPFS QQRIHHFIIH NKDTFFNNAT
RSRIVHHILQ RVKYEEGKNK IGLNRLLSNG SYEAAFPLHE GSYRSKNSIK THGAENHRHL
LYECWASWGV WYKYQPLDLV RRYFGEKIGL YFAWLGWYTG MLFPAAFIGL FVFLYGVTTL
NHCQVSKEVC QATDIIMCPI CDKYCPFMRL SDSCVYAKVT HLFDNGATVF FAVFMAVWAT
VFLEFWKRRR AVIAYDWDLI DWEEEEEEIR PQFEAKYSKK ERMNPISGKP EPYQAFADKC
SRLIVSASGI FFMICVVIAA VFGIVIYRVV TVSTFAAFKW ALIRNNSQVA TTGTAVCINF
CIIMLLNVLY EKVALFLTNL EQPRTESEWE NSFTLKMFLF QFVNLNSSTF YIAFFLGRFT
GHPGAYLRLI NRWRLEECHP SGCLIDLCMQ MGIIMVLKQT WNNFMELGYP LIQNWWTRRK
LRQEYGTQRK TSFPQWEKDY NLQPMNAYGL FDEYLEMILQ FGFTTIFVAA FPLAPLLALL
NNIIEIRLDA YKFVTQWRRP LASRAKDIGI WYGILEGIGI LSVITNAFVI AVTSDFIPRL
VYAYKYGPCA GQGEAGQKCM VGYVNASLSV FLVSDFENRS EPTSNGSEFS GSPLKYCRYR
DYRDPPHSPV PYGYTLQFWH VLAARLAFII VFEHLVFCIK HLISYLIPDL PKDLRDRMRR
EKYLIQEMMY EAELERLQKE RKERKKNGKS YHNEWP
//
