GenomeNet

Database: UniProt
Entry: G1NHY3_MELGA
LinkDB: G1NHY3_MELGA
Original site: G1NHY3_MELGA 
ID   G1NHY3_MELGA            Unreviewed;      4885 AA.
AC   G1NHY3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   16-JAN-2019, entry version 51.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSMGAP00000012824};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSMGAP00000012824};
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000012824, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000012824, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000012824}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   STRING; 9103.ENSMGAP00000012824; -.
DR   Ensembl; ENSMGAT00000013722; ENSMGAP00000012824; ENSMGAG00000012087.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155507; -.
DR   InParanoid; G1NHY3; -.
DR   OMA; PLLNEYC; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001645; Chromosome 5.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4200   4224       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4427   4447       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4494   4513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4686   4707       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4766   4789       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        3     58       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       65    110       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      118    172       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      178    235       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      246    303       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      499    710       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      926   1122       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1268   1473       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3945   3973       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      372    392       {ECO:0000256|SAM:Coils}.
FT   COILED     3237   3257       {ECO:0000256|SAM:Coils}.
FT   COILED     3597   3631       {ECO:0000256|SAM:Coils}.
FT   COILED     4350   4370       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4885 AA;  555558 MW;  DAC02124FADC01B3 CRC64;
     GGHRTLLYGH AILLRHSFSE MYLTCLTSSR SQTDKLAFDV GLRENAAGEA CWWTIHPASK
     QRSEGEKVRI GDDLILVSVS SERYLHLSMS NGSIQVDASF MQTLWNVHPT CSGSNITEGY
     LLGGHVVRFF HGHDECLTIP STDQNDSQQK KVLYETGGAG VRARSLWRVE PLRISWSGSN
     IRWGQPFRLR HITTGMYLAL NDDEGLVMLD REKSDTTSSA FCFRASKELK EKQDSTLKRD
     IDGMGVPEIK YGDSVCFVQH VASALWLTYK APDAKSARLG LLKRKVILHQ EGHMDDGLTL
     QRCQHEESQA ARIIRNTTSL FSQFISHVDD YVSIPNGNNR TLSPIALPVE EMAQTLQDLI
     KYFQPPGEDL EHEDKQNKLR SLKNRQNLFK DESKIKLKLK ICSSVLTCFT DILLTSKISS
     LIKLLSPLGY SNLFVKLLSA LIRGNRNNCT QFSSNLDWLI SKLDRLESSS GILEVLHCIL
     IESPEALNVI AEEHIKSIIS LLDKHGRNYK VLDVLCSLCV CNGVAVRANQ NLICDNLLPR
     RDLLLQTRLI NDVTSIRPNI FLGVAEGSAQ YKKWYFELII DQVDPFLTAE PTHLRVGWAS
     TSGYAPYPGG GEGWGGNGVG DDLYSFGFDG LHLWSGRVPR AVASVNQHLL SSDDVVSCCL
     DLGVPSISFR INGQPVQGMF ENFCTEGFFF PVVSLSAGVK ARFLLGGRHG EFKFLPPAGY
     APCYEALLPK EKMKLEPVKE YKRDSDGVRD LLGTTQFLSQ ASFIPCPIDT SQIALPFHLE
     KIRDKLAENI HELWGMNKIE LGWTYGKIRD DNKRHHPCLV EFSKLPETEK NYNLQMSTET
     LKTLLALGCH IVHANPAAEE DLKKVKLPKN YIMSNGYKPA PLDLSEVKLL PSQEFLVDKL
     AENAHNVWAK DRIKQGWTYG IQQDLKNKRN PRLVPYALLD ERTKKSNRDS LREAVRTFAG
     YGYNVEPPDQ EIADQTLEKV SIDKIRFFRV EQSYAVKSGK WYFEFEAVTG GDMRVGWARP
     GCRPDIELGA DDQAFVFEGS KGQRWHQGSG FFGRSWQPGD VVGCMINLDD KSIIFTLNGE
     LLITSKGSEL AFADFGIESG FVPICSLGLA QIGRMNLGMD ASTFKYYTMC GLQEGFEPFA
     VNMNRDVAMW FSKRLPTFVN VPKNHPHIEI WRIDGTIESP PRLKVTHKTF GTQNSNSDMI
     YCRLSMPIEF RSSFNFGVGV ENASSDALQK RLDIECRTLY TDKIGESFLK SHSLLSTCHP
     SEICGTCKAL YLTVIGKVKF YSHAKKKRLF SSIFRKHSQE FPASSTTVSN HTEHYLTTSS
     ENNLVLITDM FFSSFQYFYS LRIFAGQDPS SVWVGWVTPD YHFYSENFDI NKNCTVTVTL
     GDERGRVHES VKRSNCYMVW GGDITANSQR SGRSNVDLEI GCFVDLATGM LSFTGKELGT
     CYQVEPNTKL FPAAFVQPTS TNLIQFELGK LKNTMPLSAA IFKSEERNPV PQCPPRLDVQ
     TITCLWSRMP NSFLKVETER VSERHGWVVQ CLEPLQMMAL HIPEENRCVD ILELCEQEDL
     MKFHYHTLKL YSSVCALGNT RVAYALCSHV DISQLFYTID NQYLPGLLRS GFYDLLISIH
     LDHAKQAKLM MNNEFIIPVT EETRTIKLYP DETKKHGLPG VGLSTCLKPS FNFSTPCFIV
     TSEEHQTSSP EIPLDTLKSK AISMLTEAVQ CSGSHIRDPV GGHIAFQFVP VLKLIATLLI
     MGVFDDDDVK QVLILIDPNV FGDNKEETEE RTEKEEVTQV EEKAVEAGEK AVKETKTPTK
     GLLQTRLPES VKLQMCHLLN YFCDCELQHR VEAIVSFADH YVSKLQYNQK YRYNELMQAL
     NMSAALTAKK TKEFRSPPQE QINMLLNFQL GEDCPCPEEI RDELYDFHDD LLIHCGIPLE
     EEEEEEEDSS LTGKLRSLIY KIKGPPKPEK IEPREEEDKS PTTLKELISQ TMVRWSQEDQ
     IQDPELVRIM YTLLRRQYDS IGELLQALRK AYTISAGSVK DTINLLAALG QIRSLLSVRM
     GKEEELLMIN GLGDIMNNKV FYQHPNLMRV LGMHETVMDV MVNVLGGDKS QQIVFPKMVA
     SCCRFLCYFC RISRQNQKAM FEHLSYLLEN SSVGLAFPSM RGSTPLDVAA ASVMDNNELA
     LALEEPDLDK VVTYLAGCGL QSCPVLLAKG YPDIGWNPIE GERYLSFLRF AVFVNSESVE
     ENASVVVKLL IRRPECFGPE LRGEGGNGLL AAMQEAIRIS ENPSRDLPSQ GYKREGDEEE
     EEEEIVHMGN AIMSFYSALI DLLGRCAPEM HLIQSGKGEA IRIRSILRSL VPTEDLVGII
     SIPLKLSTVN KDGTVNEPDM SANFCPDHKA PMVLFLDRVY GIKDQSFLLH LLEVGFLPDL
     RASASLDTVS LSTTEAALAL NRYICSAVFP LLKRCAPLFS GTEHHASLVD SMLHTIYRLS
     KGRSLTKAQR DTIEECLLAI CQYYSHLRPS MLQQLLRRLV FDVPLLNEYC KMPLKLLTNH
     YEQCWKYYCL PSGMGSYGIA AEDELHLTEK LFWGIFDSLS HKKYDPELFR MALPCLSAIA
     GALPPDYLDT RIRSTLEKQT SVDPEGNFDP KPINTANLVL PEKLEYIVSK YAEHSHDKWA
     FDKTNNGWKY GVSLDENTKT HPLIRPFKTL TEKEKEIYRW PVRESLKTML AMGWSLERTK
     EGGEAMLQQR ENEKLRSISQ SSQVWWSSEG NGYSPAPLDL TNVVLSRELQ GMVEVMAENY
     HNIWAKKKKM ELESKGGGSH PLLVPYDTLT AKEKSRDREK AQELFKFLQV NGIIISRGLN
     DMDLDASSME KRFAFKFLKK ILKYVDSAQE FIAHLEAIVT SGKTEKSPHD QEIKFFAKVL
     LPLVDQYFTN HCLYFLSSPT KTLSSSGYAS NKEKEMVASL FCKLAALVRH RISIFGKLLR
     KILINCLHIL AQSLDTRTVM KSGSELVKAG LRAFFENAAE DLEKTSENLK LGKFTHSRTQ
     IKGVSQNINY TTVALLPVLT SIFEHISQYH FGVDLLLGDV QVSCYRILCS LYSLGTGKNI
     YVERQRPALG ECLASLAAAI PVAFLEPSLN HYNPLSVFNT KSARERAILG MPDTVEEMCP
     EIPQLDGLIK EINNLAESGA RYTEMPHVIE VILPMLCNYL SYWWERGSES VPESAGPCCT
     MITSEHLSII LGNILKIINN NLGIDEASWM KRIAVYAQPI ISKARPDLLK THFIPTLEKL
     KKKAIKIVME EEQLRADSKS DTQEAELLIL DEFAVLCRDL YAFYPMLIRY VDNNRANWLK
     KPDADSDELF RMVAEVFILW CKSHNFKREE QNFVIQNEIN NLAFLTGDTK SKMSKSGGQD
     QERKKSKRRG DLYSIQTSLI VAALKKMLPI GLNMCTPGDQ ELISLAKTRY SHKDTDEEVK
     EHIRNNLHLQ EKMQSDDPAV KWXQLNLYKD ILKSDEPPDP EKNVERVQRI SAALYHLDQV
     EQPLRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRS INLFLHGYQN YWIETEEYSF
     EEKLVQDLAT SPKKEEEEEE DTEKEQPDPL HQIILYFSRN ALTERSKLED DPLYIAYAAM
     MAKYKSCQEE EEEEEEDKEK TFEEKEMEKQ RTLYQQARLH DRGAAEMVLQ MISASKGHTG
     PMVVETLKLG IAILNGGNTI VQQKMLDYLK EKKDAGFFQS LSGLMQSCRS VLDLNAFERQ
     NKAEGLGMVT EEGTLIVRER GEKVLQHDEF TRDLFRFLQL LCEGHNNDFQ NYLRTQMGNT
     TTVNIIISTV DYLLRLQESI SDFYWYYSGK EFIDESGQRN FSKALAVTKQ IFNSLTEYIQ
     GPCIGNQQSL AHSRLWDAVV GFLHVFANMQ MKLSQDSAQI ELLKELLDLL KDMVVMLLSL
     LEGNVVNGTI GKQMVDTLVE SSSNVELILK FFDMFLKLKD LTNSDAFKEH DPDGKGIISK
     KDFQKSMEAQ KQYIQSEIEF LLSCTEADEN DMFNYIDFVE RFHEPAKDIG FNVAVLLTNL
     SEHMPNDSRL QSLLEPAESV LNYFEPYLGR IEIMGGAKKI ERVYFEISES SRMQWEKPQV
     KESKRQFIFD VVNEGGEQEK MELFVNFCED TIFEMQLASQ ISETDSAERP EEEEEEPCYI
     VDIGDDEEEE KSLESPSAFA MACAAVKKNV ANFFKMVTVK NLRKQYRKVR KMTVKEMVKV
     FFSFFWILFV GVFQLFFTIV WGIFQILWST VFGGGLVEGA KNIKVTKILG DMPDPTQFGI
     HDDVTEAEKT EGAEHGIRDE LVQFVKGEKG EADIISDIFG IPTKKEGGSK HGHDAGLGDI
     AEILGSDIQS SLENNVRKKK GLQTPETAKD AEAERKVEAE KADMEDGEKQ DKAKEEHSEQ
     QEEGKTKKKK RRHGQKIEKP VAVMANFFKA LEIYQTKMLH YLARNFYNLR FLALFVAFAI
     NFILLFYKVT EEPLDEVEED SNLWNSFEEE EEEEGMVFFV LEESTGYMAP TLRALAVIHT
     IISFVCVIGY YCLKVPLVVF KREKEVARKL EFDGLYITEQ PSEDDIKGQW DRLVINTPSF
     PNNYWDKFVK RKVINKYGDL YGAERIAELL GLDKNALDFS PVEESEPEAA SLVSWLSSID
     TKYHIWKLGV VFTDNSFLYL AWYTTMSILG HYNNFFFAAH LLDIAMGFKT LRTILSSVTH
     NGKQLVLTVG LLAVVVYLYT VVAFNFFRKF YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR
     AGGGIGDEIE DPAGDPYEIY RIVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVRE
     DMETKCFICG IGNDYFDTTP HGFETHTLQE HNLANYLFFL MYLINKDETE HTGQESFVWK
     MYQERCWDFF PAGDCFRKQY EDQLG
//
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