ID G1NIV3_MELGA Unreviewed; 931 AA.
AC G1NIV3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=von Willebrand factor D and EGF domains {ECO:0008006|Google:ProtNLM};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000013221.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000013221.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000013221.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; G1NIV3; -.
DR Ensembl; ENSMGAT00000014123.3; ENSMGAP00000013221.3; ENSMGAG00000012558.3.
DR GeneTree; ENSGT00940000160835; -.
DR HOGENOM; CLU_002130_0_0_1; -.
DR InParanoid; G1NIV3; -.
DR TreeFam; TF351702; -.
DR Proteomes; UP000001645; Chromosome 7.
DR Bgee; ENSMGAG00000012558; Expressed in breast and 2 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR14949; EGF-LIKE-DOMAIN, MULTIPLE 7, 8; 1.
DR PANTHER; PTHR14949:SF52; VON WILLEBRAND FACTOR D AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 86..259
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 793..832
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 834..869
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 871..910
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 329..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 822..831
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 838..848
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 859..868
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 931 AA; 102868 MW; 65F25B1809852502 CRC64;
MFTLDSQLLG PPNIVLSACQ VDLVPAPCSQ GSCAAAVVTV TAVTDFAQDG NRISHIRAEP
VGHRDVLWRA HASKDVKVTV QDLPTGNCYS FTDPHIITFD GWRYDNYKIG TFLLCQSTSR
AFEVHVRQWD CGGHHSATAC NCGVAAWEGS DVVRLDACNG HFQDSRPQLN IQSTEASPQV
KILTSYGGRK ITILFPSGAF IRADVSEWGM GLTVRTPSSD FNSTRGLCGL FDGISHNDLN
NVPEEDFIEE WRIPPGKSLF DKTPASSEEK QRKNYCRCQK ESTKSMPLVK MLNAFQMQSS
GCHYDNVDYT FAIPYLDITS EFVTHSGKEF ASRDDGERSP KSFDQRSLPK SVKKRGSHEE
RLKPFSQHAS MKNNSSLNFT KPAEELQRPK RQEDYFEYSA PHPLHSPSQT DTESFAYFFP
EDYFEGIRLK LPLGWPTPNG LTSAKAQEIC HGILANSTIG LVCKALLGKL IDEAINICML
DLQLKDDVAW VRALIALLEN ECERRVLRNR GEVFHVGSQS TATQEEILTI LRCPAFCNGN
GQCTDLGCQC FEDHSSYDCS TAKKQALEIT SLENKGLCDI RTSDCSRVRV FGVGFKDSPH
LRCEVTRLIH LNGEWISREQ EITQADFLSS KAVDCQIPLL NITETEAVHF VAGDEPFARW
QVKVGISSYD NTCNIDGLCY GEGESSPASP CLLCEPDISK FTWSINENNL PPVFQAPSSQ
LLTFIGENFV YQLTAVDPEG SAVLFILEAG PQDARLSPAG LLIWKVDSEE MQTFEFTVSD
ECNALSRYTV EVRVKPCSCL NGGTCVTNIK FPPGLGEYLC LCPNGFDGGL CQEDINECKS
NPCKSGTCVD GVDSYACQCP PGLGGLTCQE DKNECEEGLC FPGVSCMNTF GSYVCGICPS
GMEGNGKTCK CKSMICYNRR IYFLISKIHV C
//
