ID G1NMA6_MELGA Unreviewed; 1685 AA.
AC G1NMA6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Rho guanine nucleotide exchange factor 5 {ECO:0008006|Google:ProtNLM};
GN Name=ARHGEF5 {ECO:0000313|Ensembl:ENSMGAP00000014707.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000014707.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000014707.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000014707.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_010715237.1; XM_010716935.2.
DR Ensembl; ENSMGAT00000015645.3; ENSMGAP00000014707.3; ENSMGAG00000013903.3.
DR GeneID; 100540317; -.
DR KEGG; mgp:100540317; -.
DR CTD; 7984; -.
DR GeneTree; ENSGT01030000234571; -.
DR HOGENOM; CLU_012820_5_0_1; -.
DR InParanoid; G1NMA6; -.
DR TreeFam; TF316357; -.
DR Proteomes; UP000001645; Chromosome 1.
DR Bgee; ENSMGAG00000013903; Expressed in ileum and 8 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11940; SH3_ARHGEF5_19; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845:SF2; DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1264..1448
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1599..1660
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1685 AA; 188854 MW; 24488ACDFD89C89A CRC64;
MSISLLDSAE GAELSSPEDC LSAPGEAAEM PGRPSNPVQK VPVVLEEEHG DADPQQSLSE
WEGEIILEGG LHCSLKLKQG ELADLESNQD FSYLSPIQDG PVTGNVIPQS VDLSTECSQS
QTELAFQVSD PQSQYQKSPL ADDISFQREA PKCFLVFKTI SEGHYKAEPS LCKVEPLQEI
DAGAEQKHSS KKVALATNER PTLEITAEGM ANLYTSDNGK ESRRVLQSWE ENTESCYQLT
STLTDESQIS SVQTGGNISA CEIRSSKLLK DQGSVMIHKE NPSTSKCIHI EDDSRKTDSR
PTSSASCVFY KKDTAKKVKR VNTSQHKETA QEEAVSGLQQ EQEKKECKDQ NMQEEGKFLK
PKKQEKKEQN EQEQQLQREE LRLKSMSSAL LSETLYMPRY KVDFCGLENV FLAEQTGTAI
PGECDFMREH LGESVLLKAH VTAVGSRCQI PFASPFPSES LNLVGEVPMA PLHVCRISDL
ENTVRFSISS QDSVEVDRDD NIRLGEEDEH SGEPGKAAQI FVEGEAPHCG GVAAPSSIEN
QEASVPVCST EKIDPADPVD PHPTAENLRK AEFCDFVSDL PLELTFVASM SGSQQENTGG
GALMNPEDCP SSSLNKLPYS IKKHANQAVS VCMQDLASVE TIVLTADPEE GSGSYKLLAP
EEDFHEDLSV SSSFSVVYTS SLPAEKSLPG DRETLFFVAE PLESTQTWGR TSTPLNQPET
ILQYQHPPEE SAIMQENETG TNVFHEAQQV PLFDQSDWNP RSRISSILST LTWPPEGDMV
LAVNQGGRSL SPKPNTTLTL VSEPDAKQLP SHVPRPVQAQ APAPNANHCV QPLAHESHET
LIPVPDSRPH LNCNMDDHDL LALTISRPLW TAATVSYANT ANFSPDRSLT DKVVFVPAAK
ELNFCDLGTQ DTEASNDSGV NLLAKGFSTV GNEALASCSD TSTETVIQHV GVQREKSSPD
HLSWSSLEGL GTFTDSKSRD SLQSLPMLAF TNPIHFLQLS PPSPPTTQTT CREGEVSGEL
QWVQRTDFFG VDTPNIQAPS AITEKAESEG RVKQRLEEQQ EKYHLVSQSK EIPKHLPLEK
SSSWPDKKTI GVVAKEPRAS QESLSKCRVK SKDWHRQGLK RISVPPDVLQ EVCPVHSEEE
VHKVHREPPV SSETVILREK KPADTMGTFK RRHSKLINSS KLLYQEYSDV VLNKAIQSQK
RVDSFAEDTE SCLPSSPRLR RKVLSPQDSY LQRLSVSSNP SLWQDIPMIR GSRMLLSMSR
DEQKLQEAKF ELIMSEASYL RSLNVAVDHF QRSTELHAIL SNQERQWLFS RLQDVRDVSA
SFLFDLEEKF EEDMFTFHVC DVALKHAPEF RRVYLPYVTN QTYQEQTFQR LLSGNAGFQQ
VLERLESDPV CQRLSLKSFL ILPFQRITRL KLLLQNILKR TRPGSEEEVQ ATQAYDALEK
LIKDCNENVQ RMKSTEELIY LSQKIEFECK IFPLVSQSRR LVKCGELTAL DFNTPSPKWK
VTTRPIYLHL FNDCLLLSRP KEGGRFVVFD HAAFSDVRGE KCEMKLHGTN KNVFRLFLLQ
NCQGKRVEFL FRTETHNEKL RWISALVPPH GELDLLECPD APQVQCIRMY KARENDELAL
EKADIIMVMQ YSNDGWMEGV RLSDRERGWF PSEYVELISS KHARQKNLKE EQRVKNAKQQ
VFCRK
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