ID G1NN45_MELGA Unreviewed; 423 AA.
AC G1NN45;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Serine/threonine/tyrosine kinase 1 {ECO:0000313|Ensembl:ENSMGAP00000015045.1};
GN Name=STYK1 {ECO:0000313|Ensembl:ENSMGAP00000015045.1};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000015045.1, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000015045.1, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000015045.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003202714.2; XM_003202666.3.
DR RefSeq; XP_010716858.1; XM_010718556.2.
DR RefSeq; XP_010716867.1; XM_010718565.2.
DR RefSeq; XP_010716873.1; XM_010718571.2.
DR RefSeq; XP_010716889.1; XM_010718587.2.
DR RefSeq; XP_010716898.1; XM_010718596.2.
DR RefSeq; XP_010716905.1; XM_010718603.2.
DR RefSeq; XP_010716914.1; XM_010718612.2.
DR AlphaFoldDB; G1NN45; -.
DR Ensembl; ENSMGAT00000015993.2; ENSMGAP00000015045.1; ENSMGAG00000014227.3.
DR GeneID; 100538871; -.
DR KEGG; mgp:100538871; -.
DR CTD; 55359; -.
DR GeneTree; ENSGT00940000157871; -.
DR HOGENOM; CLU_000288_7_7_1; -.
DR InParanoid; G1NN45; -.
DR OMA; IYRTKMH; -.
DR OrthoDB; 1614410at2759; -.
DR TreeFam; TF316675; -.
DR Proteomes; UP000001645; Chromosome 1.
DR Bgee; ENSMGAG00000014227; Expressed in ileum and 17 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF592; SERINE_THREONINE_TYROSINE KINASE 1; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 3.
DR PRINTS; PR00109; TYRKINASE.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 115..385
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 63..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 257
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 423 AA; 48087 MW; 775B2ECD6B1219FA CRC64;
MAGDVKRFTR MLLECNSNDK LCVVREYQTE VIVVPALLVG FFVILLTVIL WLHCRGLRTR
TKREESSSSG QQVNNKNQQE SSSQENHCIQ LNEILLSSAS LTLKELQIPR EKLSLGSLQI
VKHGRNGSIY RAELETRNSG KTKSVILKAL QDLVSHQEVK DFLGRIKFHQ NLGYHENLVE
LFGCCVDRFP LYMVMEDVSL GDLLKFLWTC RKDVMTMDGV PYDLTERQVY EVGQQVAAAL
AYLEQKKLFH GYIAARNVLL QHNFTAKLCG FGLAYKAHTY GASSVTEMVP VKWQAPERLL
KNPPSIKTDI WSFGILLYEM ITLGDPPYPE VRPSDMLPYL QRRNIMKQPS SCHPAMYSIM
KSCWQWNATD RPSPSDLIQS LQTAMKTSND QRVLQVPELV DPELYADVTG VAMDSLVSDY
TVL
//
