ID G1NRM0_MELGA Unreviewed; 477 AA.
AC G1NRM0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Torsin-1A C-terminal domain-containing protein {ECO:0000259|Pfam:PF21376};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000016715.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000016715.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000016715.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC {ECO:0000256|ARBA:ARBA00006235}.
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DR AlphaFoldDB; G1NRM0; -.
DR Ensembl; ENSMGAT00000017689.2; ENSMGAP00000016715.2; ENSMGAG00000015773.2.
DR GeneTree; ENSGT00950000182888; -.
DR HOGENOM; CLU_053537_1_0_1; -.
DR InParanoid; G1NRM0; -.
DR TreeFam; TF314941; -.
DR Proteomes; UP000001645; Chromosome 19.
DR Bgee; ENSMGAG00000015773; Expressed in gizzard and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR024829; IEX-1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049337; TOR1A_C.
DR InterPro; IPR010448; Torsin.
DR PANTHER; PTHR10760; TORSIN; 1.
DR PANTHER; PTHR10760:SF1; TORSIN-4A; 1.
DR Pfam; PF21376; TOR1A_C; 1.
DR Pfam; PF06309; Torsin; 1.
DR PRINTS; PR02100; GENEIEX1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 420..474
FT /note="Torsin-1A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21376"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 53994 MW; 584AA8627C031433 CRC64;
MGDAAESSAK GEGPYADGHV EGEMCCSDSD GEGELLCKEA DAKGEASCSE SEGEEVPDTE
IPAASKKISF ISSPLRAIVR LKQRYRVQKK SRLHFELPQE KSSEPVHARL LQRQFSLNRS
GLYGSSKSFF NQSSFKTSQY FTFDTSLEEW AMSKPRRKKK RRKSRIVLYP DKTKRYLPTE
EKSNAKRCLL LLIVIIFFQI LNAIENLDDN LQKYDLDGLE KTMHREVFGQ KLAVESIMQL
LKDYLATHIH NKPLVLSLNG PTGVGKSHVG WLLAKHFRSV MDNDFVLQYF VMHHCPSGVD
PLTCETDLSK KISDMVTRAE IEEKIPLFIL DEVELMSPVL LDTLSRFFEP NQTNEFLNAI
YILISNIGGG EITKFIIQNA SAELLQQRSG AEELLSVIQP VLSHAHPLWK AADVVPFVLL
ERSHVVDCFL EEMRREGLYP EQSHVERLAG QLSYYTTGDK QFSRLGCKQV VAKVNLL
//
