ID G1NRN2_MELGA Unreviewed; 719 AA.
AC G1NRN2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365};
DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728};
GN Name=MPEG1 {ECO:0000313|Ensembl:ENSMGAP00000016731.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000016731.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000016731.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000016731.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome
CC membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MPEG1 family.
CC {ECO:0000256|ARBA:ARBA00007256}.
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DR RefSeq; XP_003206399.1; XM_003206351.3.
DR AlphaFoldDB; G1NRN2; -.
DR Ensembl; ENSMGAT00000017705.2; ENSMGAP00000016731.2; ENSMGAG00000015790.2.
DR GeneID; 100538524; -.
DR KEGG; mgp:100538524; -.
DR CTD; 219972; -.
DR GeneTree; ENSGT00390000008048; -.
DR HOGENOM; CLU_023578_1_0_1; -.
DR InParanoid; G1NRN2; -.
DR TreeFam; TF331165; -.
DR Proteomes; UP000001645; Chromosome 5.
DR Bgee; ENSMGAG00000015790; Expressed in spleen and 16 other cell types or tissues.
DR GO; GO:0061474; C:phagolysosome membrane; IEA:Ensembl.
DR GO; GO:0022829; F:wide pore channel activity; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR CDD; cd22579; MPEG1_P2; 1.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR039707; MPEG1.
DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00023130};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..719
FT /note="Macrophage-expressed gene 1 protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033006148"
FT TRANSMEM 655..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..347
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT REGION 692..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 78661 MW; CB8C06768BA0573C CRC64;
MVWVLRVVLL TQALAMAVAE VERPQEPLSS VGFQDCKKAL KLPTLEVLPG GGWDNLRNLD
MGRVIDLSYS LCKTTEDGSY IIPDDIFTIP RKQSNLDINS EIIESWKDYK SVTSASINLE
LSLFSAINGK FSYDFHQAKT HQVQDKAVTT RVQVRNLVYT AKIDPGASLD KGFKKQLLTI
ASHLENNQTR MADFLSEVLV LNYGTHTITS VDAGASLVQE DQIKATFLKD SWAMRSSITA
SAAVAFHSIV NVKTEESQGT SSAFTKQYVE NRTNSRVESI GGTPFYPGIT LKTWQEGISN
QLVAIDRSGL PLYFFISPST LPELPSPTVK KLAKRVEMAI RRYYTFNTYP GCTDATSPNF
NFYANADDGS CMGTMTNFTF GGVFQECTGL AGPDTNELCR ALEQKNPLTG AFSCPTSYSP
VLLGMQEREE GHSHLECHNK CTLGIFCHRV CRDVFWLSRV QFRAYWCVAS GLVSPDSGYL
FGGLFSSRSV NPLTGAQSCP SRYFLLKLFD DLRLCVSQDY EGGSRYAVPF GGFFSCQTGN
PLGGQHQGTA EDPYTKRCPT GFSQHLALIS DSCQVEYCVQ AGVFTAGSLP PARLPPFTRP
PANLPAIDTV LVSNGDGESA WVRDGTGRAW RLAQPIEIQQ AAEMVRGRAL TGGEVAGVAA
AVVVGLVTTL AMVCYGRWRY RRRGYVAMSE GATPVERPGD STAVNMGEGH QQESAGLTE
//
