ID G1NRW4_MELGA Unreviewed; 860 AA.
AC G1NRW4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN Name=TLR5 {ECO:0000313|Ensembl:ENSMGAP00000016869.1};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000016869.1, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000016869.1, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000016869.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR RefSeq; XP_003203871.1; XM_003203823.3.
DR RefSeq; XP_019468196.1; XM_019612651.1.
DR RefSeq; XP_019468197.1; XM_019612652.1.
DR AlphaFoldDB; G1NRW4; -.
DR Ensembl; ENSMGAT00000017843.2; ENSMGAP00000016869.1; ENSMGAG00000015929.2.
DR GeneID; 100546336; -.
DR KEGG; mgp:100546336; -.
DR CTD; 7100; -.
DR GeneTree; ENSGT00940000167009; -.
DR HOGENOM; CLU_006000_4_1_1; -.
DR InParanoid; G1NRW4; -.
DR OMA; AQSRYFC; -.
DR OrthoDB; 4633557at2759; -.
DR TreeFam; TF351113; -.
DR Proteomes; UP000001645; Chromosome 2.
DR Bgee; ENSMGAG00000015929; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF525; TOLL-LIKE RECEPTOR 5; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 3.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..860
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003416275"
FT TRANSMEM 641..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 692..837
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 860 AA; 98822 MW; EFB32D2C37D9E284 CRC64;
MLHQQLIIVF GISLAGDICA SRRCYSEDQV SMYNSCNLTS VPPVPKDTAK LFLTYNYIRQ
VTATSFPLLE DLFLLEIGTQ RVFPLYIGKE AFKNLPNLRV LDLGFNNILL LDLDSFAGLQ
RLTILRLFQN NLGDSILEER YFQDLSSLEE LDLSGNQITK LHPHPLFYNL TILKAVNLKF
NKISNLCESN LTSFQGKHFS FFSLSSNTLY KTDKMVWAKC PNPFRNITFN SLDVSENGWS
TETVQYFCTA IKGTQINYLS FRLHTMGSGF GFNNLKNPDK DTFTGLARSD LRLLDISNGF
IFSLNSLIFK SLGNLEFLNL FRNKVNQIQK QAFSGLENLK ILNLSSNLLG ELYDYTFEGL
HSIIYIDLQQ NHIGMIGQKS FSNLVSLKII DLRDNALKKL PSFPHLTTAF LGDNKLISVA
HAAIAATHIE LERNWLANLG DLYVLFQVPD MQYLSLKQNR ISYCEKHVNA IENSQLIYMD
LGENMLQLVW ERGLCLDVFR TLSKLQILFL NNNYLSALPQ EIFSGLTSLK ILNLASNLLS
HLSLGVFPRS LINLNLSGNQ LFSPKPEVFM TLSILDITHN KYVCDCALKS LLVWLNETNV
TLAGSESDRY CVYPPALAGV PVSLLTYDDC DEDELQQTLR FSVFIFISVT LLMFLMSAII
FTRCRGICFV WYKTITKTLI GSHPPAADTS EYMYDAYLCY SKNDFEWVQN SLLKHLDSQY
FDKNRFTLCF EERDFLPGEE HINNIRDAIW KSRKTICVVT RHFLKDGWCV EAFNFAQSRY
FSDLKEVLIM VVVGSLSQYQ LMKHKPIRIF LQRSRYLRWP EDYQDIDWFL DNLSSQILKE
KRVQRNVSDM ELQTIATVSH
//
