ID G1NSI4_MYOLU Unreviewed; 843 AA.
AC G1NSI4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Aryl hydrocarbon receptor {ECO:0000256|ARBA:ARBA00015909};
GN Name=AHR {ECO:0000313|Ensembl:ENSMLUP00000000092.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000092.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000092.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000092.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AAPE02008950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006085112.1; XM_006085050.2.
DR AlphaFoldDB; G1NSI4; -.
DR STRING; 59463.ENSMLUP00000000092; -.
DR Ensembl; ENSMLUT00000000097.2; ENSMLUP00000000092.2; ENSMLUG00000000097.2.
DR GeneID; 102432278; -.
DR KEGG; mlf:102432278; -.
DR CTD; 196; -.
DR eggNOG; KOG3560; Eukaryota.
DR GeneTree; ENSGT00940000154486; -.
DR HOGENOM; CLU_010044_1_1_1; -.
DR InParanoid; G1NSI4; -.
DR OMA; GCDAKGQ; -.
DR OrthoDB; 5360131at2759; -.
DR TreeFam; TF352074; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0034753; C:nuclear aryl hydrocarbon receptor complex; IEA:Ensembl.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:Ensembl.
DR GO; GO:0001094; F:TFIID-class transcription factor complex binding; IEA:Ensembl.
DR GO; GO:0001223; F:transcription coactivator binding; IEA:Ensembl.
DR GO; GO:0019933; P:cAMP-mediated signaling; IEA:Ensembl.
DR GO; GO:1904613; P:cellular response to 2,3,7,8-tetrachlorodibenzodioxine; IEA:Ensembl.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:1904322; P:cellular response to forskolin; IEA:Ensembl.
DR GO; GO:0071219; P:cellular response to molecule of bacterial origin; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0002841; P:negative regulation of T cell mediated immune response to tumor cell; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0030888; P:regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR GO; GO:0006805; P:xenobiotic metabolic process; IEA:InterPro.
DR CDD; cd11436; bHLH-PAS_AhR; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR039091; AHR/AHRR.
DR InterPro; IPR033348; AHR_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR PANTHER; PTHR10649; ARYL HYDROCARBON RECEPTOR; 1.
DR PANTHER; PTHR10649:SF9; ARYL HYDROCARBON RECEPTOR; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 27..80
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 117..180
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 432..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 95413 MW; FD101FB16B583A1D CRC64;
MNVSSFNITY ASRKRRKPVQ KTIKPIPAEG IKSNPSKRHR DRLNTELDRL ANLLPFPQDV
INKLDKLSVL RLSVSYLRAK SFFDVALKSS PTDRNGIQDN CRTKFGEGLN FHEGEFLLQA
LNGFVLVVTT DALVFYASST IQDYLGFQQS DVIHQSVYEL IHTEDRAEFQ RQLHWALNPS
QCTDSGQRID EANGLLQPAV YYDPDQLPPE NSSFMERSFI CRLRCLLDNS SGFLAMNFQG
RLKYLHGQNK KGKDGSVLPP QLALFAIATP LQPPSILEIR TKNFIFRTKH KLDFTPTGCD
AKGKLVLGYT EAELCMRGSG YQFLHAADML YCAEYHMRMI KTGESGMIVF RLLTKGNRWT
WIQSNARLVY KNGRPDYIIA TQRPLTDEEG TEHLKKRNMK LPFMFATGEA VLYETTNPFP
PMMDPLPVRT KNVTSGKDSA TQATLNKDSP HPSSVFGAIM QQDESIYLCP ASSSDPFERI
FLNESMDKCS KWQDSIAPVG SDILEHEQIG QSQEMNPTLP EGHGGLFPDN NNSDLYSIMK
HLGVDFEDVK HMQQNEEFFR TDFSGENDFR DIDLTDEILT FVQDSLSKST LACPGYQQQP
SRALNSSCMV QEHLQLEQQH QKQVAMEQQQ QLCQKMKNMQ VNGMFANWSS NHSVPFNCPQ
QDLQQYNVFS DLPGTNQEFP YKSEIDTMPY TQNFIPCNSS VLPQQSQGTQ LDFPLGNFEP
SPYPTATSNL EDFVTCLQAP ENQKHKLNLQ SSLVTPQTCY SGAVSMYPYQ LEPQQSNVAQ
IQYGPTLPGP QAFLTKFPNG VLNEIYPAEL NTINNSQTTT HLQSLHHPSE NGPFPDLTSS
RFL
//
