ID G1NSJ4_MYOLU Unreviewed; 1191 AA.
AC G1NSJ4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=PH domain and leucine rich repeat protein phosphatase 1 {ECO:0000313|Ensembl:ENSMLUP00000000103.2};
GN Name=PHLPP1 {ECO:0000313|Ensembl:ENSMLUP00000000103.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000103.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000103.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000103.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02014666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02014667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02014668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02014669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NSJ4; -.
DR STRING; 59463.ENSMLUP00000000103; -.
DR Ensembl; ENSMLUT00000000110.2; ENSMLUP00000000103.2; ENSMLUG00000000103.2.
DR eggNOG; KOG0618; Eukaryota.
DR GeneTree; ENSGT00940000158137; -.
DR InParanoid; G1NSJ4; -.
DR OMA; GHNQICD; -.
DR TreeFam; TF315993; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0009649; P:entrainment of circadian clock; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0046328; P:regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:1900744; P:regulation of p38MAPK cascade; IEA:Ensembl.
DR GO; GO:0002667; P:regulation of T cell anergy; IEA:Ensembl.
DR CDD; cd13322; PH_PHLPP-like; 1.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF37; PH DOMAIN AND LEUCINE-RICH REPEAT PROTEIN PHOSPHATASE 2; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00364; LRR_BAC; 11.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 20..120
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 655..902
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 938..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1191 AA; 131306 MW; 3C0DCC8F1C427882 CRC64;
LNCLFALVPG KPHSTCSSER IQLSGMYNVR KGKMQLPVNR WTRRQVILCG TCLIVSSVKD
SLTGKMHVLP LIGGKVEEVK KHQHCLAFSS SGPQSQTYYI CFDTFTEYLR WLRQVSKVAS
QRISSVDLSC CSLEHLPANL FYSQDLTHLN LKQNFLRKQE PGSIDAFNRF TKLKSLNLSN
NHLGDFPLAV CNIPTLTELN VSCNALRAVP AAVGVMHNLQ TFLLDGNFLQ SLPAELENMH
QLSYLGLSFN EFTDIPEVLE KLTAVDKLCM SGNCMETLRL QALRKMPHIK HVDLRLNIIK
KLIADEVDFL QHVTQLDLRD NKLGDLDAMI FNNIEVLHCE RNQLVTLNIC GYFLKALYAS
SNELVQLDVY PVPNYLFYMD VSRNCLENVP EWVCESRKLE VLDIGHNQIC ELPARLFCNS
SLRKLLAGHN QLTSLPERLE RTSVEVLDVQ HNQLLELPPN LLMKADSLRF LNASANKLET
LPAATLSEET SSILQELYLT NNNLTDKCVP LLTGHPHLKI LHMAYNRLQS FPASKMAKLE
ELEEVDISGN KLKAIPTTIT NCRRMHTVIA HSNCIEVFPE VMQLPEIKCV DLSCNELSEV
TLPENLPPKL QELDLTGNPR LALDHKTLEL LNNIRCFKID QPSAGDASGA PAVWSHGYTE
ASGVKNKLCV AALSVNNFCD NREALYGVFD GDRNVEVPYL LQCTMSDILA EELQKTKNEE
EYMVNTFVVM QRKLGTAGQK LGGAAVLCHI KHDPVDPGGS FTLTSANVGK CQTVLCRNGK
PLPLSRSYVM SCEEELRRIK QHKAIITEDG KVNGVTESTR ILGYTFLHPS VVPRPHVQSV
ALTPQDEFFI LGSKGLWDSL SIEEAVGAVR NVPDALSAAK KLCTLAQSYG CRDSLSAVVV
QLSVTEDSFC CCDLGAGGAG PPPSPGIFPP SVSMVIKDRP SDGLGVPSSS SGMASEISSE
LSTSEMSSEV GSTASDEPPP GALSESGPPY PSEQRCLLHP ACLSSAFQRQ LSSATFSSAF
SDNGLDSDDE EPIEGVFSNG SRVEVEVDIH CGRAKDRDKQ QHLLQVPAEA SDEGIVISAN
EDEPGLPRKA DFASMGTIGR RRANGSVAPQ ERSHNVIEVA TEAPLRKPGG YFAAPAQPDP
EDQFIIPPEL EEEVKEIMKH HQQQQPPAQL PLQPPRQCPA DPLPDYCDTP L
//
