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Database: UniProt
Entry: G1NSP5_MYOLU
LinkDB: G1NSP5_MYOLU
Original site: G1NSP5_MYOLU 
ID   G1NSP5_MYOLU            Unreviewed;      1823 AA.
AC   G1NSP5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-APR-2018, entry version 56.
DE   SubName: Full=Kinesin family member 1B {ECO:0000313|Ensembl:ENSMLUP00000000163};
GN   Name=KIF1B {ECO:0000313|Ensembl:ENSMLUP00000000163};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000163, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000000163, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000000163}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00283, ECO:0000256|SAAS:SAAS00583243}.
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DR   EMBL; AAPE02050829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02050830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000000163; -.
DR   Ensembl; ENSMLUT00000000179; ENSMLUP00000000163; ENSMLUG00000000169.
DR   eggNOG; KOG0245; Eukaryota.
DR   eggNOG; COG5059; LUCA.
DR   GeneTree; ENSGT00890000139327; -.
DR   InParanoid; G1NSP5; -.
DR   OMA; HEFELAQ; -.
DR   OrthoDB; EOG091G009V; -.
DR   TreeFam; TF105221; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR   GO; GO:0005875; C:microtubule associated complex; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0003777; F:microtubule motor activity; IEA:Ensembl.
DR   GO; GO:0008089; P:anterograde axonal transport; IEA:Ensembl.
DR   GO; GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:Ensembl.
DR   GO; GO:0007270; P:neuron-neuron synaptic transmission; IEA:Ensembl.
DR   CDD; cd00060; FHA; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR022164; Kinesin-like.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR   InterPro; IPR032405; Kinesin_assoc.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR24115; PTHR24115; 1.
DR   Pfam; PF12473; DUF3694; 1.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF12423; KIF1B; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   Pfam; PF16183; Kinesin_assoc; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00240; FHA; 1.
DR   SMART; SM00129; KISc; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|SAAS:SAAS00875240}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|SAAS:SAAS00874078};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT   DOMAIN        5    354       Kinesin motor. {ECO:0000259|PROSITE:
FT                                PS50067}.
FT   DOMAIN      556    612       FHA. {ECO:0000259|PROSITE:PS50006}.
FT   DOMAIN     1708   1806       PH. {ECO:0000259|PROSITE:PS50003}.
FT   NP_BIND      97    104       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00283}.
FT   COILED      365    385       {ECO:0000256|SAM:Coils}.
FT   COILED      470    490       {ECO:0000256|SAM:Coils}.
FT   COILED      675    702       {ECO:0000256|SAM:Coils}.
FT   COILED      711    731       {ECO:0000256|SAM:Coils}.
FT   COILED      842    862       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1823 AA;  204874 MW;  62025DD6563D2D07 CRC64;
     MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIVNP KNPKEAPKSF SFDYSYWSHT
     SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP
     QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED
     LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DTETNLSTEK
     VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK
     TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIKCNAVI
     NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLIDD YSGSGGKYLK DFQNNKHRYL
     LASENQRPGN FSTASMGSLT SSSSSCSLNS QVGLTSVTSI QERIMSTPGG EEAIERLKES
     EKIIAELNET WEEKLRKTEA IRMERSGVRD EMGVAIREDG GTLGVFSPKK TPHLVNLNED
     PLMSECLLYY IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CIFRSERNNS GDVIVTLEPC
     ERSETYVNGK RVAHPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA ETPSEPVDWT
     FAQRELLEKQ GIDMKQEMEK RLQEMEILYK KEKEEADLLL EQQRLDYESK LQALQKQVET
     RSLAAETTEE EEEEEEVPWT QHEFELAQWA FRKWKSHQFT SLRDLLWGNA VYLKEANAIS
     VELKKKVQFQ FVLLTDTLYS PLPPELLPTD MEKTHEDRPF PRTVVAVEVQ DLKNGATHYW
     SLEKLKQRLD LMREMYDRAG EMASSGQDES ETTMTGSDPF YDRFHWFKLV GSSPIFHGCV
     NERLADRTPS PTFSTADSDI TELADEQQDE MEDFDDEAFV DDTGSDAGTE EGSDLFSDGH
     DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG EVRGFLRVAV QAIAAYLADE
     EAPDYGSGIR QSGTAKISFD NEYFNQSDFP SVAMTRSGLS LEELRIVEGQ GQSSEVISPP
     EEINRMNDLD LKSSTLLDGK MVMEGFSEEI GNHLKLGSAF TFRVTVLQAS GILPEYADIF
     CQFNFLHRHD EAFSTEPLKN NGRGSPLGFY HVQNIAVEVT ESFVEYIKTK PIVFEVFGHY
     QQHPLHLQGQ DLNSPPQPSR RFFPPPMPLS KPVPATKLNT MSKTSLGQSM SKYDLLVWFE
     ISELEPTGEY IPAVVDHTAG LPCQGTFLLH QGIQRRITMT IVHEKGSELH WKDVRELVVG
     RIRNKAEVDE AAVDAILSLN IISAKYLKSS HNSSRTFYRF EAVWDSSLHN SLLLNRVTPY
     GEKIYMTLSA YLELDHCIQP AVITKDVCMV FYSRDAKISP AATRSHQTHS LYEKILNSNR
     VTGIYELSLC KMADTGSPGM QRRRRKVLDT SVAYVRGEEN LAGWRPRGDS LILEHQWELE
     KLELIHEVEK TRHFLLLRER LGDSAPKSLS DSLSPSLSSG TLSTSTSISS QISTTTFESA
     ITPSESSGYD SADIESLVDR EKELATKCLQ LLTHTFNREF SQVHGSISDC KLSDISPIGR
     DPSVSSFSSS TLTPSSTCPS LVDSRSNSVD QNKPLVPLIP VLLTCPSTPT LLLSSVIPHI
     GSPILGKTNG DNFNSLRPDI EEIRPGSVVS KKGYLHFKEP FSSNWAKHFV VVRRPYVFIY
     NSDKDPVERG IINLSTAQVE YSEDQQAMVK SPNIFAVCTK HRGVLLQALN DKDMSDWLYA
     FNPLLAGTIR SKLSLRGSSQ LKY
//
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