ID G1NSZ7_MYOLU Unreviewed; 534 AA.
AC G1NSZ7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=LON peptidase N-terminal domain and ring finger 1 {ECO:0000313|Ensembl:ENSMLUP00000000272.2};
GN Name=LONRF1 {ECO:0000313|Ensembl:ENSMLUP00000000272.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000272.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000272.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000272.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02012342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NSZ7; -.
DR STRING; 59463.ENSMLUP00000000272; -.
DR Ensembl; ENSMLUT00000000298.2; ENSMLUP00000000272.2; ENSMLUG00000000300.2.
DR eggNOG; KOG4159; Eukaryota.
DR GeneTree; ENSGT00440000033329; -.
DR HOGENOM; CLU_013989_1_1_1; -.
DR InParanoid; G1NSZ7; -.
DR OMA; KYKKQGV; -.
DR TreeFam; TF327043; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16514; RING-HC_LONFs_rpt2; 1.
DR Gene3D; 2.30.130.40; LON domain-like; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR046336; Lon_prtase_N_sf.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23327:SF4; LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 1; 1.
DR PANTHER; PTHR23327; RING FINGER PROTEIN 127; 1.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00464; LON; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51787; LON_N; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 240..278
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 326..527
FT /note="Lon N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51787"
FT REGION 124..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 61082 MW; 0C18538C572F36B7 CRC64;
SEPSNLTLKI YRAESYAGLG EFKAAIEDLN AVLFQLPSWP EVYFRKGKVL HDAGFLGDAL
QLFLQCLALD EDFAPAKLEV EKILFDLLSP ENLKEGLKDS SWSSLPCTKN KPFGFPSVME
EFPSASELSP EQNEEIPETP AEPVKGSLNR AQSAQAINST EMPTREDCLK RVSSEPLLSV
EEKGALLKRK LSLLEQDVIV NEDGRNKLKK QGETPNEVCT FSLTYGDIPE ELIDVSDFEC
SLCMRLFFEP VTTPCGHSFC KNCLERCLDH TPYCPLCKES LKEYLADRRY CVTQLLEELI
VKYLPDELSE RKKIYDEETA ELSHLTKNVP IFVCTIAYPT VPCPLHVFEP RYRLMIRRSI
QTGTKQFGMC VSDKQNGFAD YGCMLQIRNV HFLPDGRSVV DTVGGKRFKV LKRGMKDGYC
TADIEYLEDV KVENEDELES LRQLHNLVYS QACSWFQNLR DRFRSQILQH FGSMPRREEN
LQATPNGPAW CWWLLAVLPV DPRYQLSVLS MKSLKERLTK IQHILTYFSR DQSK
//
