ID G1NTN4_MYOLU Unreviewed; 510 AA.
AC G1NTN4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Double-stranded RNA-binding protein Staufen homolog 2 {ECO:0000256|ARBA:ARBA00024122};
GN Name=STAU2 {ECO:0000313|Ensembl:ENSMLUP00000000537.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000537.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000537.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000537.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02012731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02012732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NTN4; -.
DR STRING; 59463.ENSMLUP00000000537; -.
DR Ensembl; ENSMLUT00000000592.2; ENSMLUP00000000537.2; ENSMLUG00000000592.2.
DR eggNOG; KOG3732; Eukaryota.
DR GeneTree; ENSGT00940000154977; -.
DR HOGENOM; CLU_009602_2_0_1; -.
DR InParanoid; G1NTN4; -.
DR OMA; PQNITEM; -.
DR TreeFam; TF350296; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR CDD; cd19882; DSRM_STAU2_rpt2; 1.
DR CDD; cd19884; DSRM_STAU2_rpt3; 1.
DR CDD; cd19886; DSRM_STAU2_rpt4; 1.
DR Gene3D; 3.30.160.20; -; 4.
DR Gene3D; 6.10.250.1360; -; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR044464; STAU2_DSRM_2.
DR InterPro; IPR044473; STAU2_DSRM_3.
DR InterPro; IPR044474; STAU2_DSRM_4.
DR InterPro; IPR032478; Staufen_C.
DR PANTHER; PTHR46054:SF1; DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 2; 1.
DR PANTHER; PTHR46054; MATERNAL EFFECT PROTEIN STAUFEN; 1.
DR Pfam; PF00035; dsrm; 4.
DR Pfam; PF16482; Staufen_C; 1.
DR SMART; SM00358; DSRM; 4.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 4.
DR PROSITE; PS50137; DS_RBD; 4.
PE 4: Predicted;
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 8..75
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 95..181
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 207..274
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 307..375
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 55..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 56296 MW; F5D6B244F71E0957 CRC64;
MAKPKEKTPM CLVNELARFN RVQPQYKLLR ERGPAHAKMF SVQLSLGEQT WESEGSSIKK
AQQAVASKAL TESTLPKPVQ KPPKSNVNNN PGSITPTVEL NGLAMKRGEP AIYRPLDPKP
FPNYRANYNF RGMYNQRYHC PMPKIFYVQL TVGNNEFFGE GKTRQAARHN AAMKALQALQ
NEPIPEKSSQ NGESGKEMDD DKDANKSEIS LVFEIALKRN MPVSFEVIKE SGPPHMKSFV
TRVSVGEFSA EGEGNSKKLS KKRAATTVLQ ELKKLPPLPV VEKPKLFFKK RPKTIVKAGP
EYGQGMNPIS RLAQIQQAKK EKEPDYVLLS ERGMPRRREF VMQVKVGNEV ATGTGPNKKI
AKKNAAEAML LQLGYKASTS LQDQLDKTGE NKGWSGPKAG FPEPTNNTPK GILHLSPDVY
QEMEASRHKV ISGNTLGYLS PKDMNQPSSS FFSISPTSNS SATIARELLM NGTSPTAEAI
GLKGSPPTPP CSAVQPSKQL EYLARIQGFQ
//
