ID G1NV56_MYOLU Unreviewed; 215 AA.
AC G1NV56;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=UBA domain containing 2 {ECO:0000313|Ensembl:ENSMLUP00000001137.2};
GN Name=UBAC2 {ECO:0000313|Ensembl:ENSMLUP00000001137.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000001137.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000001137.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000001137.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAPE02041126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02041127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02041128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NV56; -.
DR STRING; 59463.ENSMLUP00000001137; -.
DR Ensembl; ENSMLUT00000001240.2; ENSMLUP00000001137.2; ENSMLUG00000001242.2.
DR eggNOG; KOG4463; Eukaryota.
DR GeneTree; ENSGT00950000182999; -.
DR HOGENOM; CLU_057710_2_0_1; -.
DR InParanoid; G1NV56; -.
DR OMA; GHISITN; -.
DR TreeFam; TF333335; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:1904153; P:negative regulation of retrograde protein transport, ER to cytosol; IEA:Ensembl.
DR GO; GO:0070972; P:protein localization to endoplasmic reticulum; IEA:Ensembl.
DR CDD; cd14305; UBA_UBAC2; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041928; UBA_UBAC2.
DR PANTHER; PTHR43066; RHOMBOID-RELATED PROTEIN; 1.
DR PANTHER; PTHR43066:SF21; UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 175..215
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
SQ SEQUENCE 215 AA; 24485 MW; 1EDBF3DBB5E2A168 CRC64;
LAPVFALFVP FYCSIPRVQV AHILGPLSIT NKTLIYILGL QLFTSGSYIW IVAISGLISG
ICYNSKILQV HQVLYIPSWM AKFCSWTLEP IFSSSEPTTE ARVGMGATVD IQRQQRMELL
DRQLMLSQFA QARRQRQQQG GMINWNRLFP PLRQRRNINY QEGRRAEQQA SPPLEVSEEQ
VARLMEMGFS RGDALEALRA SNNDLNVATN FLLQH
//
