ID G1NW37_MYOLU Unreviewed; 761 AA.
AC G1NW37;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=BMP/retinoic acid-inducible neural-specific protein 1 {ECO:0000256|ARBA:ARBA00041019};
GN Name=BRINP1 {ECO:0000313|Ensembl:ENSMLUP00000001517.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000001517.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000001517.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000001517.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the BRINP family.
CC {ECO:0000256|ARBA:ARBA00010360}.
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DR EMBL; AAPE02022923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006091148.1; XM_006091086.2.
DR RefSeq; XP_006091149.1; XM_006091087.2.
DR AlphaFoldDB; G1NW37; -.
DR STRING; 59463.ENSMLUP00000001517; -.
DR Ensembl; ENSMLUT00000001653.2; ENSMLUP00000001517.2; ENSMLUG00000001652.2.
DR GeneID; 102437708; -.
DR KEGG; mlf:102437708; -.
DR CTD; 1620; -.
DR eggNOG; ENOG502QT9H; Eukaryota.
DR GeneTree; ENSGT00940000158084; -.
DR HOGENOM; CLU_018347_0_0_1; -.
DR InParanoid; G1NW37; -.
DR OMA; MSESWAS; -.
DR OrthoDB; 3949486at2759; -.
DR TreeFam; TF331600; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0001662; P:behavioral fear response; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0071300; P:cellular response to retinoic acid; IEA:Ensembl.
DR GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
DR GO; GO:0035640; P:exploration behavior; IEA:Ensembl.
DR GO; GO:0042711; P:maternal behavior; IEA:Ensembl.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:InterPro.
DR GO; GO:0007614; P:short-term memory; IEA:Ensembl.
DR GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR GO; GO:0071625; P:vocalization behavior; IEA:Ensembl.
DR InterPro; IPR033237; BRINP.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR15564:SF7; BMP_RETINOIC ACID-INDUCIBLE NEURAL-SPECIFIC PROTEIN 1; 1.
DR PANTHER; PTHR15564; MACPF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF19052; BRINP; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022810};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Growth arrest {ECO:0000256|ARBA:ARBA00022810};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..761
FT /note="BMP/retinoic acid-inducible neural-specific protein
FT 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003417032"
FT DOMAIN 72..251
FT /note="MACPF"
FT /evidence="ECO:0000259|SMART:SM00457"
SQ SEQUENCE 761 AA; 88762 MW; AD3BB0602A7A77E7 CRC64;
MNWRFVELLY FLFIWGRISV QPSHQEPAGT DQHVSKEFDW LISDRGPFHH SRSYLSFVER
HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPLPLMPE FQRSIRLLGR RPTTQQFIDT
IIKKYGTHLL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR
RLHEIQISTG AIKVTETRTG PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPPYLQE
KFVQSALSYI MCNGEGEYVC QNSQCRCQCA EEFPQCNCPI TDIQIMEHML ANMAKSWAEA
YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQN RYKLLQSSME AQRQKIQRTA
RKLFGLSVRC RHNPNHHLPR ERTIQQWLAR VQSLLYCNEN GFWGTFLESQ RSCVCHGSTT
LCQRPIPCII GGNNSCAMCS LANISLCGSC NKGYKLYRGR CEPQNVDSER SEQFISFETD
LDFQDLELKY LLQKMDSRLY VHTTFVSNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM
VIGMSMRICQ MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKV RLQNSQCYNW
TLLLGNRWKT FFETVHIYLR SRTRLATVLR NETGQGPVDL SDPNKRQFYI KISDVQVFGY
SLRFNADLLR SAVQQVNQSY TQGGQFYSSS SVMLLLLDIR DRINRLAPPV APGKPQLDLF
SCMLKHRLKL TNSEIIRVNH ALDLYNTEIL KQSDQMTAKL C
//
