ID G1NXD5_MYOLU Unreviewed; 624 AA.
AC G1NXD5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 {ECO:0000313|Ensembl:ENSMLUP00000002026.2};
GN Name=SAMHD1 {ECO:0000313|Ensembl:ENSMLUP00000002026.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000002026.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000002026.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000002026.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02019330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02019331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02019332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02019333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02019334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02019335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02019336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NXD5; -.
DR STRING; 59463.ENSMLUP00000002026; -.
DR Ensembl; ENSMLUT00000002224.2; ENSMLUP00000002026.2; ENSMLUG00000002214.2.
DR eggNOG; KOG2681; Eukaryota.
DR GeneTree; ENSGT00390000013867; -.
DR HOGENOM; CLU_026821_1_2_1; -.
DR InParanoid; G1NXD5; -.
DR OMA; DYIARDC; -.
DR TreeFam; TF316113; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0097197; C:tetraspanin-enriched microdomain; IEA:Ensembl.
DR GO; GO:0032567; F:dGTP binding; IEA:Ensembl.
DR GO; GO:0008832; F:dGTPase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:Ensembl.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0046061; P:dATP catabolic process; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0006203; P:dGTP catabolic process; IEA:Ensembl.
DR GO; GO:0110025; P:DNA strand resection involved in replication fork processing; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR GO; GO:0016446; P:somatic hypermutation of immunoglobulin genes; IEA:Ensembl.
DR Gene3D; 3.30.70.2760; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 55..112
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 72411 MW; A227899664B3ECA4 CRC64;
MQGADSEQPP KRPRCDSSPR TPQNTRFKAA EGSPDPLPSD HKTWDPEQVC PLSEAQWLRG
FRTDRYIDVF KKKEITGSLL FNLDESHLDN LGIRSISAQS AGLICLDQLI HSEKDVDTMP
IVINDPIHGH IELHPLLIRI IDTPQFQRLR YIKQLGGTYY VFPGASHNRF EHSLGEVFLA
TLFKMIKRKE TVFFFSYPEN LCVPLGQESK CYEMGHGPFS HMFDGRFIPL ARQGMKWKHE
QGSVDMFEHL INSNDLKPIM EYYGLIPEED ITFIKEQITG PPKTPVKDVS WPYKGRPKEK
SFLYEIVANK RSGIDVDKWD YFARDCHHLG IQNSFDYKRF LKFARVCEVG NLKHICTREQ
EIGNLYDMFH IRTSLHRRAY QHKVGNIIDT MITDAFLKAD PYIEITGTEG KKYHISTAID
DMEAFTKLTD NIFLEILHSA DPKLAAAREI LEKIQRRNLY KYVGQTQPNK RRITKEDSEK
FREELAKAKP DVITLEVELQ AEDFIVDVIN MDYGMEDKNP IDNVHFYCKA DLNQAFKISQ
EQASQLLPKQ FKEQLIRVYC KKTDKKSVHA AQQYFVHWCT KKDFTKPQDG DVIAPLITPL
KKEWNYPNSA ERPASTHARR TLDF
//
