GenomeNet

Database: UniProt
Entry: G1NXV0_MYOLU
LinkDB: G1NXV0_MYOLU
Original site: G1NXV0_MYOLU 
ID   G1NXV0_MYOLU            Unreviewed;      1629 AA.
AC   G1NXV0;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 78.
DE   SubName: Full=Latent transforming growth factor beta binding protein 1 {ECO:0000313|Ensembl:ENSMLUP00000002215.2};
GN   Name=LTBP1 {ECO:0000313|Ensembl:ENSMLUP00000002215.2};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000002215.2, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000002215.2, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000002215.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   -!- SIMILARITY: Belongs to the LTBP family.
CC       {ECO:0000256|ARBA:ARBA00038081}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AAPE02028510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02028511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02028512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02028513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000002215; -.
DR   Ensembl; ENSMLUT00000002437.2; ENSMLUP00000002215.2; ENSMLUG00000002425.2.
DR   eggNOG; KOG1217; Eukaryota.
DR   GeneTree; ENSGT00940000155823; -.
DR   HOGENOM; CLU_001884_1_0_1; -.
DR   InParanoid; G1NXV0; -.
DR   OMA; SQRCTKX; -.
DR   TreeFam; TF317514; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0001527; C:microfibril; IEA:Ensembl.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0050436; F:microfibril binding; IEA:Ensembl.
DR   GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
DR   GO; GO:1901388; P:regulation of transforming growth factor beta activation; IEA:Ensembl.
DR   GO; GO:0035583; P:sequestering of TGFbeta in extracellular matrix; IEA:Ensembl.
DR   CDD; cd00054; EGF_CA; 12.
DR   Gene3D; 2.10.25.10; Laminin; 18.
DR   Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR017878; TB_dom.
DR   InterPro; IPR036773; TB_dom_sf.
DR   PANTHER; PTHR24034:SF111; -; 1.
DR   PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF12662; cEGF; 2.
DR   Pfam; PF07645; EGF_CA; 12.
DR   Pfam; PF00683; TB; 4.
DR   SMART; SM00181; EGF; 18.
DR   SMART; SM00179; EGF_CA; 16.
DR   SUPFAM; SSF57196; EGF/Laminin; 10.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR   SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR   PROSITE; PS00010; ASX_HYDROXYL; 11.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01186; EGF_2; 9.
DR   PROSITE; PS50026; EGF_3; 11.
DR   PROSITE; PS01187; EGF_CA; 6.
DR   PROSITE; PS51364; TB; 4.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022530};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          93..125
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          305..337
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          463..508
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          532..572
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          583..635
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          823..864
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          946..986
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          987..1027
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1028..1068
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1069..1109
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1110..1151
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1152..1189
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1255..1309
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          1432..1485
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          1570..1614
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          140..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          656..695
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          708..731
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        97..107
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        115..124
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        309..319
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        327..336
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   1629 AA;  177485 MW;  2FB8052FA99C7742 CRC64;
     LQGLRPPPPP PPEPARPRSG GQLHPQPGGT RRAVPDRQTK AGKPRDPKVP QEEQSGGGSR
     LKAQQKQQLQ GVNVCGGQCC QGWSKAPGSQ RCTKPSCVPP CQNGGMCLRP QLCVCKPGTK
     GKACEMTAAQ DTSSPVFAGQ GPGAAASWVP PEQASKRTSS KKADTLPRVS PVAQMTLTLK
     PKPSVGLAQQ IHSQVTPLSS QNVVIHHGQT QEYVLKPKYF AAQKVISGEQ STEGSFPLRY
     GPDQVAAPFQ LSNHTGRIKV VFTPSICRVT CTKGSCQNSC EKGNTTTLIS ENGHAADTLT
     ATNFRVVICH LPCMNGGQCS SRDKCQCPPN FTGKLCQIPV HGASVPKLYQ HSQQSGKALG
     THVVHSTHTL PLTMTSQQGV KVKFPPNIVN IHVKHPPEAS VQIHQVSRID GPTGQKVKEA
     QPGQSQISYQ GLPVQKTQTV HSTYSHQQVI PHIYPVAAKT QLGRCFQETV GSQCGKALPG
     LSKQEDCCGT VGTSWGFHKC QKCPKKPSYH GYNQMMECLQ GYKRVNNTFC QDINECQLQG
     VCPNGECLNT MGSYRCTCKM GFGPDPTFTT CVPDTPVISE EKGPCYRLVS SGRQCMHPLS
     VHLTKQLCCC SVGKAWGPHC EKCPLPGTAA FKEICPGGMG YTVSGVHRRR PIHHHVGKGP
     VFVKPKNTQP VAKSTHPPPL PAKEEPVEAL TFSREHGPGV AEPEVLVATA PPEKEIPSLD
     QEKTKLEPGQ PQLSPGISTI HLHPQFPVVI EKTSPPVPVE VAPEASTSSA SQVIAPTQVT
     EINECSVNPD ICGAGHCVNL PVRYTCICYE GYKFSEQQRK CTDIDECTQA PHLCSQGRCE
     NTEGSFLCIC PAGFMASEEG TSCIDVDECL RPDVCGEGHC INTVGAFRCK YCDSGYRMTP
     GGHCEDIDEC LSPSTCPDEQ CVNSPGSYQC VPCTEGFRGW NGQCLDVDEC LDPKVCTNGT
     CSNLEGSYMC SCHKGYTPTP DHKHCKDIDE CQQGNLCMNG QCKNTEGSFR CTCGQGYQLS
     AAKDQCEDID ECQHRHLCTN GQCRNTEGSF RCVCDQGYRA SALGDHCEDI NECLEDNSVC
     QGGDCINTKG SYDCTCPDGF QLNDNKGCQD INECEQPGLC GPRGECLNTD GSFHCVCEQG
     FTISADGRTC EDIDECVNNT VCDRHGFCDN TAGSFRCLCY QGFQAPQDGQ GCVDVNECEL
     LSGVCGEAFC ENVEGSFLCV CADETQEYSP MTGQCRSRAP GDLNVEVEQS REEKKECYYN
     LNDASLCDNV LAPNVTKQEC CCTSGAGWGD NCEIFPCPVL GTAEFTEMCP RGKGFVPTGE
     SSYEAGDKDY KDADECLLFG QEICKNGFCL NTQPGYECYC KQGTYYDPVK LQCFDMDECQ
     DPNSCIDGQC INTEGSYNCF CTHPMVLDAS EKRCVRPSES HEQIEETDVY QDLCWEHLSD
     DYVCSRPLVG KQTTYTECCC LYGEAWGMQC ALCPMKDSDD YAQLCNIPVT GRRQPYGRDA
     LVDFSEQYAP EADPYFIQDR FLNSFEELQA EECGILNGCE NGRCVRVQEG YTCDCFDGYH
     LDMAKMTCVD VNECDELNNR MSLCKNAKCI NTEGSYKCLC LPGYVPSDKP NYCTPLNTAL
     NLDKDSDLE
//
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