ID G1P0C9_MYOLU Unreviewed; 353 AA.
AC G1P0C9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Septin 12 {ECO:0000313|Ensembl:ENSMLUP00000003205.2};
GN Name=SEPTIN12 {ECO:0000313|Ensembl:ENSMLUP00000003205.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000003205.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000003205.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000003205.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|RuleBase:RU004560}.
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DR EMBL; AAPE02020981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006090457.1; XM_006090395.2.
DR AlphaFoldDB; G1P0C9; -.
DR STRING; 59463.ENSMLUP00000003205; -.
DR Ensembl; ENSMLUT00000003522.2; ENSMLUP00000003205.2; ENSMLUG00000003525.2.
DR GeneID; 102439755; -.
DR KEGG; mlf:102439755; -.
DR CTD; 124404; -.
DR eggNOG; KOG1547; Eukaryota.
DR GeneTree; ENSGT00940000158310; -.
DR HOGENOM; CLU_017718_7_1_1; -.
DR InParanoid; G1P0C9; -.
DR OMA; AHCEFLL; -.
DR OrthoDB; 5396944at2759; -.
DR TreeFam; TF101078; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0031105; C:septin complex; IEA:Ensembl.
DR GO; GO:0097227; C:sperm annulus; IEA:Ensembl.
DR GO; GO:0005819; C:spindle; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF66; SEPTIN-12; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 40..312
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
SQ SEQUENCE 353 AA; 40471 MW; 12FB44CC9C60761A CRC64;
MDPLRRSLSP CSSRPTSCEM LGYVGIEAVL DQLKIKAMKM GFEFNIMVVG QSGLGKSTMV
NTLFKSKIWK STPSGLVLGP TPQTLQLHSM THVIEEKGVR LKLTVTDTPG FGDQINNDKC
WDPILGYING QYEQYLQEEI LITRQRHIPD TRVHCCVYFV PPTGHCLRPL DIEFLRRLCR
TVNVVPVIAR ADSLTIEERE NFRRTIQHNL RTHSIDVYPQ QCFDEDVNDK ILNCKIRDRI
PFAVVGADRE HMVNGRCVLG RKTKWGIIEV ENMEHCEFPL LRDLLIRSHL QDLKDITHNV
YYENYRVCRL NESHMLPQGP GWVNLDPTPA SPSAIPGPSK MCRWAQDNPS EEY
//
