ID G1P0D8_MYOLU Unreviewed; 756 AA.
AC G1P0D8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 08-NOV-2023, entry version 53.
DE RecName: Full=Splicing factor Cactin {ECO:0000256|ARBA:ARBA00034534};
GN Name=CACTIN {ECO:0000313|Ensembl:ENSMLUP00000003214.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000003214.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000003214.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000003214.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CACTIN family.
CC {ECO:0000256|ARBA:ARBA00006895}.
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DR EMBL; AAPE02052842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P0D8; -.
DR STRING; 59463.ENSMLUP00000003214; -.
DR Ensembl; ENSMLUT00000003531.2; ENSMLUP00000003214.2; ENSMLUG00000003521.2.
DR eggNOG; KOG2370; Eukaryota.
DR GeneTree; ENSGT00950000183102; -.
DR HOGENOM; CLU_011759_0_0_1; -.
DR InParanoid; G1P0D8; -.
DR OMA; HIDFWND; -.
DR TreeFam; TF300906; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032688; P:negative regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0032717; P:negative regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR InterPro; IPR019134; Cactin_C.
DR InterPro; IPR018816; Cactin_central.
DR PANTHER; PTHR21737:SF6; CACTIN; 1.
DR PANTHER; PTHR21737; POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3; 1.
DR Pfam; PF10312; Cactin_mid; 1.
DR Pfam; PF09732; CactinC_cactus; 1.
DR SMART; SM01050; CactinC_cactus; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 276..463
FT /note="Splicing factor cactin central"
FT /evidence="ECO:0000259|Pfam:PF10312"
FT DOMAIN 632..756
FT /note="Splicing factor Cactin C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09732"
FT REGION 1..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 232..277
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..53
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 756 AA; 89162 MW; 5C8F7A2983F91A7E CRC64;
SSQLMGRDTR SRSRSTGRRS RRARRRRSRS GSRSRHRSGS HGRRNRRRRD DEGRRRRRSR
ERRSDSEEDQ WQRRGRQSRS PQPPQWRSQD QSSPSDSGNE RQWQHQGRWA RRRRTRSCSS
SSSSASPDHS QSSREVAAAL SQQQNLQERL RLREERKQQE ELMKAFETPE EKRARRLAKK
EAKERKKREK MGWGEEYMGY TNTDNPFGDN NLLGTFIWNK ALEKKGISHL EEKELKERNK
RIQEDNRLEL QKVKQLRLER EREKAMREQE LEMLQREKEA EHFKTWEEQE DNFHLQQAKL
RSKIRIRDGR AKPIDLLAKY ISAEDDDLAV EMHEPYTFLN GLTVADMEDL LEDIQVYMEL
EQGKNVDFWR DMTIITEDEI SKLRKLEASG KGPGERREGV NTSVSSDVQL VFKGKTYSQL
QVIFQGIEGK IRAGGPNLDM GYWESLLQQL RAHMARARLR ERHQDVLRQK LYKLKQEQGV
ESEPLFPILK QEPPSPGHSL EPEDQALTPP GPSLEGGPVE PEAEEATPAE GEAEGEAVLM
EEDLIQQSLD DYDAGKYSPR LLTAHELPLD AHVLEPDEDL QRLQLSRQQL QVTGDASESA
EDIFFRRAKE GMGQDEAQFS VEMPLTGKAY LWADKYRPRK PRFFNRVHTG FEWNKYNQTH
YDFDNPPPKI VQGYKFNIFY PDLIDKRSTP EYFLEACPDN KDFATLRFHA GPPYEDIAFK
IVNREWEYSH RHGFRCQFAN GIFQLWFHFK RYRYRR
//