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Database: UniProt
Entry: G1P0D8_MYOLU
LinkDB: G1P0D8_MYOLU
Original site: G1P0D8_MYOLU 
ID   G1P0D8_MYOLU            Unreviewed;       756 AA.
AC   G1P0D8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   08-NOV-2023, entry version 53.
DE   RecName: Full=Splicing factor Cactin {ECO:0000256|ARBA:ARBA00034534};
GN   Name=CACTIN {ECO:0000313|Ensembl:ENSMLUP00000003214.2};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000003214.2, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000003214.2, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000003214.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CACTIN family.
CC       {ECO:0000256|ARBA:ARBA00006895}.
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DR   EMBL; AAPE02052842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G1P0D8; -.
DR   STRING; 59463.ENSMLUP00000003214; -.
DR   Ensembl; ENSMLUT00000003531.2; ENSMLUP00000003214.2; ENSMLUG00000003521.2.
DR   eggNOG; KOG2370; Eukaryota.
DR   GeneTree; ENSGT00950000183102; -.
DR   HOGENOM; CLU_011759_0_0_1; -.
DR   InParanoid; G1P0D8; -.
DR   OMA; HIDFWND; -.
DR   TreeFam; TF300906; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:Ensembl.
DR   GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0032688; P:negative regulation of interferon-beta production; IEA:Ensembl.
DR   GO; GO:0032717; P:negative regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
DR   GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR   GO; GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR   InterPro; IPR019134; Cactin_C.
DR   InterPro; IPR018816; Cactin_central.
DR   PANTHER; PTHR21737:SF6; CACTIN; 1.
DR   PANTHER; PTHR21737; POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3; 1.
DR   Pfam; PF10312; Cactin_mid; 1.
DR   Pfam; PF09732; CactinC_cactus; 1.
DR   SMART; SM01050; CactinC_cactus; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT   DOMAIN          276..463
FT                   /note="Splicing factor cactin central"
FT                   /evidence="ECO:0000259|Pfam:PF10312"
FT   DOMAIN          632..756
FT                   /note="Splicing factor Cactin C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09732"
FT   REGION          1..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          161..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          482..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          232..277
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        14..53
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..75
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   756 AA;  89162 MW;  5C8F7A2983F91A7E CRC64;
     SSQLMGRDTR SRSRSTGRRS RRARRRRSRS GSRSRHRSGS HGRRNRRRRD DEGRRRRRSR
     ERRSDSEEDQ WQRRGRQSRS PQPPQWRSQD QSSPSDSGNE RQWQHQGRWA RRRRTRSCSS
     SSSSASPDHS QSSREVAAAL SQQQNLQERL RLREERKQQE ELMKAFETPE EKRARRLAKK
     EAKERKKREK MGWGEEYMGY TNTDNPFGDN NLLGTFIWNK ALEKKGISHL EEKELKERNK
     RIQEDNRLEL QKVKQLRLER EREKAMREQE LEMLQREKEA EHFKTWEEQE DNFHLQQAKL
     RSKIRIRDGR AKPIDLLAKY ISAEDDDLAV EMHEPYTFLN GLTVADMEDL LEDIQVYMEL
     EQGKNVDFWR DMTIITEDEI SKLRKLEASG KGPGERREGV NTSVSSDVQL VFKGKTYSQL
     QVIFQGIEGK IRAGGPNLDM GYWESLLQQL RAHMARARLR ERHQDVLRQK LYKLKQEQGV
     ESEPLFPILK QEPPSPGHSL EPEDQALTPP GPSLEGGPVE PEAEEATPAE GEAEGEAVLM
     EEDLIQQSLD DYDAGKYSPR LLTAHELPLD AHVLEPDEDL QRLQLSRQQL QVTGDASESA
     EDIFFRRAKE GMGQDEAQFS VEMPLTGKAY LWADKYRPRK PRFFNRVHTG FEWNKYNQTH
     YDFDNPPPKI VQGYKFNIFY PDLIDKRSTP EYFLEACPDN KDFATLRFHA GPPYEDIAFK
     IVNREWEYSH RHGFRCQFAN GIFQLWFHFK RYRYRR
//
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