ID G1P0M0_MYOLU Unreviewed; 986 AA.
AC G1P0M0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Desmoglein 3 {ECO:0000313|Ensembl:ENSMLUP00000003310.2};
GN Name=DSG3 {ECO:0000313|Ensembl:ENSMLUP00000003310.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000003310.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000003310.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000003310.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}.
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DR EMBL; AAPE02023695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P0M0; -.
DR STRING; 59463.ENSMLUP00000003310; -.
DR Ensembl; ENSMLUT00000003636.2; ENSMLUP00000003310.2; ENSMLUG00000003631.2.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT01030000234624; -.
DR HOGENOM; CLU_005284_0_0_1; -.
DR InParanoid; G1P0M0; -.
DR OMA; CQCDNRD; -.
DR TreeFam; TF331809; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR009122; Desmosomal_cadherin.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR24025:SF3; DESMOGLEIN-3; 1.
DR Pfam; PF00028; Cadherin; 3.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01818; DESMOCADHERN.
DR PRINTS; PR01819; DESMOGLEIN.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; Cadherin-like; 4.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 66..153
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 154..263
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 264..383
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 380..491
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 986 AA; 106632 MW; EE09064734578FA0 CRC64;
LIQKCLGTIK CLQVVLLVHG EMRIEVKYEK FFDERAAWRK WRHKREWVKF ARPCREEEDN
SKRNPIAQIS SDFHAKQKIT YRITGIGIDQ PPLGIFVVDR NTGDINITAI VDREQTPNFH
ITCHALNALG QEVEKPLILT VKILDINDNP PVFSQSVFMG EIEENSPANS LVMILNATDA
DEPNHLNSKI AFKIVSQEPA GIPMFLMSRH SGEVRTLTNS LDREQVSSYR LIVSGADQDG
EGLSSQCESS IKVKDVNDNF PMFKESQYSV SIEENTLSSE LLRFQVIDLD EEFTDNWLAE
YFFTSGNEGN WFEIQTDART NEGILKVVKP LDYEQLQNAQ FSIAVKNKAE FHQSVISQYR
VQSTQVKVQV INVREGIAFR PASKTFTVQK GISRKKLINY ILGTYAAIDE DTGKPASNVR
YALGRNDGGF LIIDSKTAQI KFARNMVRDS TFIFNRTIIA EVLAIDENTG KTSTGTVYVE
VPGFNENCPT TVLEKERICS SSPSVVVSAR AQDGDRYTGP YTFSLEDESV KLPIVWRITT
VNATSALLTT QQQLPPGRYP ISLVIADRQD RQCDTPEGLA VEVCQCDNRD TCTEPQPGPR
YGDQPSGRLG PNAIGLILLG LLLLLLAPLL LLTCDCGKGP IGGATTGFIP VPEGSEGTIH
QWGIEGAQPE DKEITNICVP LITSNGADFM ENSDVCMNAC ARGMTAEGAS GMELTTNLGA
AAGSGAATGS GAAAGFGATT GLGFCSAGQS GTMRTRHSTG GTHRECGEGV ISMNFLESYF
SQKAFACAEQ DDGQEANDCL LIYDNEGLGA PSSPVGSLGC CSFIADDLDE SFLDSLGPKF
KQLAEISLGL DGKGQQSQLP THGSGSGTGA CGHSVEIQHS ELSGGQTTSG GQGACAWSAS
GSVLQPAICI PDPLQQGGYL VTETYSASGS LAQPPTAALD PLLMQNVVMT ERVICPIASG
HGHLHGAAEL RGSCNMIYTE DPCSRL
//
