ID G1P1Z3_MYOLU Unreviewed; 792 AA.
AC G1P1Z3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Anaphase-promoting complex subunit 4 {ECO:0000256|ARBA:ARBA00016067, ECO:0000256|PIRNR:PIRNR037303};
DE AltName: Full=Cyclosome subunit 4 {ECO:0000256|PIRNR:PIRNR037303};
GN Name=ANAPC4 {ECO:0000313|Ensembl:ENSMLUP00000003864.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000003864.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000003864.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000003864.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle.
CC {ECO:0000256|PIRNR:PIRNR037303}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|PIRNR:PIRNR037303}.
CC -!- SIMILARITY: Belongs to the APC4 family.
CC {ECO:0000256|PIRNR:PIRNR037303}.
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DR EMBL; AAPE02026107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P1Z3; -.
DR STRING; 59463.ENSMLUP00000003864; -.
DR Ensembl; ENSMLUT00000004243.2; ENSMLUP00000003864.2; ENSMLUG00000004233.2.
DR eggNOG; KOG4640; Eukaryota.
DR GeneTree; ENSGT00390000004612; -.
DR HOGENOM; CLU_018724_0_0_1; -.
DR InParanoid; G1P1Z3; -.
DR OMA; HCKLFVP; -.
DR TreeFam; TF105443; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:UniProtKB-UniRule.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:UniProtKB-UniRule.
DR GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024789; APC4.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR024790; APC4_long_dom.
DR InterPro; IPR017169; APC4_metazoa.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13260; ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4; 1.
DR PANTHER; PTHR13260:SF0; ANAPHASE-PROMOTING COMPLEX SUBUNIT 4; 1.
DR Pfam; PF12896; ANAPC4; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR PIRSF; PIRSF037303; APC4; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|PIRNR:PIRNR037303};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|PIRNR:PIRNR037303};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|PIRNR:PIRNR037303};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PIRNR:PIRNR037303}.
FT DOMAIN 11..101
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 217..415
FT /note="Anaphase-promoting complex subunit 4 long"
FT /evidence="ECO:0000259|Pfam:PF12896"
FT REGION 758..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 756
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000256|PIRSR:PIRSR037303-2"
FT CROSSLNK 782
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000256|PIRSR:PIRSR037303-2"
SQ SEQUENCE 792 AA; 90045 MW; 5B330429102A9869 CRC64;
KHLPQERRVL VWSPKRDLIA LANTAGEVLL HRLASFHRVW SFPPNENTGK EVTCLAWRPD
GKLLAFALAD TKKIVLCDVE KPESLHSFSV EAPVSCMHWM EVTAESSVLT SFYNAEDESN
LLLPKLPTLP KNYSNTSKIF SEENSDEIIK LLGDVRLNIL VLGGSSGFIE LYAYGMFKIA
RVTGIVGTCL ALCLSSDLKS LSVVTEVSAT GVSEVSYFQL ETNLLYSFLP EVTRMARKFT
HISALLQYVN LSLTCMCEAW EEILMQMDSR LTKFVQEKNT TTSVQDEFMH LLLWGKASAE
LQTLLMNQLT VKGLKKLGQS IESSYSSIQK LVISHLQSGS ESLLYHLSEL KGMASWKQKY
EPLGLDAAGI EDAITAVGSF ILKANELLQV IDSSMKNFKA FFRWLYVAML RMTEDHVIPE
LNKMTQKDIT FVAEFLTEHF NEAPDLYNRK GKYFNVEKVG QYLKDEDDDL VSPPNTEGNQ
WYDFLQNSSH LKESPLLFPY YPRKSLHFVK RRMENIIDQC LQKPADVIGK SMNQAICIPL
YKDTRSEDST RRLFKFPFLW NNKTSNLHYL LFTILEDSIY KMCILRRHTD ISQSVSNGLI
AIKFGSFTYA TTEKVRRSTY SCLDAQFYDD ETVTVVLKDT VGREGRDRLL VQLPLSSVYN
CEDSAEYQFT GNYSTRLDEQ CGAIPTRTMH FEKHWRLLES MKAQYVAGNG FRKVSCVLSS
NLRHVRVFEM DIDDEWELDE SSDDDEEASN KPVKIKEEVL SESEAESQPA GAAASAPEIV
IKVEKLDPEL DS
//
