ID G1P234_MYOLU Unreviewed; 2369 AA.
AC G1P234;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
GN Name=SPTB {ECO:0000313|Ensembl:ENSMLUP00000003910.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000003910.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000003910.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000003910.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
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DR EMBL; AAPE02022573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000003910; -.
DR Ensembl; ENSMLUT00000004293.2; ENSMLUP00000003910.2; ENSMLUG00000004280.2.
DR eggNOG; KOG0517; Eukaryota.
DR GeneTree; ENSGT00940000158908; -.
DR HOGENOM; CLU_000146_1_2_1; -.
DR InParanoid; G1P234; -.
DR OMA; EPADMTS; -.
DR TreeFam; TF313446; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0008091; C:spectrin; IEA:InterPro.
DR GO; GO:0014731; C:spectrin-associated cytoskeleton; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR GO; GO:0098885; P:modification of postsynaptic actin cytoskeleton; IEA:Ensembl.
DR CDD; cd21319; CH_SPTB_rpt2; 1.
DR CDD; cd21317; CH_SPTBN2_rpt1; 1.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 8.
DR Gene3D; 1.20.58.60; -; 12.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR016343; Spectrin_bsu.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF248; SPECTRIN BETA CHAIN, ERYTHROCYTIC; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 17.
DR PIRSF; PIRSF002297; Spectrin_beta_subunit; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00033; CH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 17.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 13.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002297};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 57..161
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 177..282
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 2219..2329
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 2081..2113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2155..2218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 461..502
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2179..2193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2369 AA; 272158 MW; E82BEF6A27ECA6D2 CRC64;
PADMTSATEF ENVANQPPYS RINARWDAPD DELDNDNSSA RLFERSRIKA LADEREVVQK
KTFTKWVNSH LARKSCRITD LYKDLRDGQM LIKLLEVLSG EMLPKPTKGK MRIHCLENVD
KALQFLKEQR VHLENMGSHD IVDGNHRLVL GLIWTIILRF QIQDIVVPEG PEGRETRSAK
DALLLWCQMK TAGYPHVNVT NFTSSWKDGL AFNALIHKHR PDLIDFDKLK DSNARHNLEH
AFDVAERQLG IIPLLDPEDV FTENPDEKSI ITYVVAFYHY FSKMKVLAVE GKRIGKVIDH
AIETEKMIEK YSGLASDLLT WIEQTITVLN SRKFANSLTG VQQQLQAFST YRTVEKPPKF
QEKGNLEVLL FTIQSRMRAN NQKVYTPHDG KLVSDINRAW ESLEEAEYRR ELALRNELIR
QEKLEQLARR FDRKAAMRET WLNENQRLVA QDNFGYDLAA VEAAKKKHEA IETDTAAYEE
RVRALEDLAQ ELEKENYHDQ KRITARKDNI LRLWSYLQEL LASRRQRLET TLALQKLFQD
MLHSIDWMDE IKAHLLSAEF GKHLLEVEDL LQKHKLMEAD IAIQGDKVKA INTATLQFTE
GKGYQPCDPQ VIQDRVSHLE QCFEELSNMA AGRKAQLEQS KRLWKFFWEM DEAESWIKEK
EQIYSSLDYG KDLTSVLILQ RKHKAFEDEL RGLDTHLDQI FQEAEGMVAR KQFGHPQIEA
RIKEVSAQWD QLKELAAFRK KNLQDAENFF QFQGDADDLK AWLQDAHKLL SGEDVGQDEG
ATRALGKKHK DFLEELEESR AVMEHLERQA QGFPQEFRDS PDVTNRLQAL RDLYQQVVAQ
ADLRRQKLQE ALDLYTVFGE TDACELWMGE KEKWLAQMEI PDTLEDLEVV QHRFDILDQE
MKTLMTQIDG VNLAANSLVE SGHPRSGEVK QYQDHLNTRW QAFQTMVSDR REAVGSALRV
HNYCVDCEET SKWILDKTKV VESTKDLGRD LTGVIAIQRK LSGLERDVAA IQTRVGALER
ESRWLMESHP ELKEDIGRRQ AYVEELWQGL QQALQGQEAS LGEASQLQAF LQDLDDFQGW
LSMAQKAVAS EDTPESLPEA EQLLQQHAAI KDEIDGHQDS FERVKASGEK VLQGQMDPEY
LLLGQRLEGL GTGWDALRRM WESRGHFLAQ CLGFQEFQKD AKQAEAILSN QEYTLAHLET
PDSLEAAEAG IRKFEDFLVS MENNQDKVLN PVDSGNKLVA EGNLYADKIK EKVQSIEDRH
RKNNEKAQEA SVLLKDNLEL QNFLQNCQEL TLWINDKLLT SQDVSYDEAR NLHNKWLKHQ
AFMAELASHE GWLESIDAEG KQLMEEKPQF AALVSQRLEA LHRLWDELQA TTKEKAQQLS
AARSSDLRSK THADLNKWIS AMEDQLRSDD PGKDLTSVNR MLAKLKRVED QVNVRKEELG
ELFAQMPSLD EEEGGADMSI EKRFLDLLEP LGKRKKQLES SRAKLQISRD LEDETLWVEE
RLPLAQSSDY GINLQTVQLF MKKNQTLQNE ILGHAPRVED VLQRGQRLVE EAEIDCGDIE
ERLGHLQSSW DTLREAAAGR LQRLRDASEA QQYYLDAGEA EAWISEQELY VISDETPKDE
EGAIVMLKRH LRQQRAVEEY GRNIKQLAGR AQGLLAAGHP EGEQIIRLQG QVDKQYAGLK
DMAEERKRKL ENMYHLFQLK READDLEQWI AEKELVASSP EMGQDFDHVT LLRDKFRDFA
RETGAIGQER VDNVNAIIER LIDAGHGEAA TIAEWKDGLN EMWADLLELI DTRMQLLAAS
YDLHRYFYTG TEILGLIDEK HRELPEDVGL DASTAESFHR VHTAFERELH LLGVQVQQFQ
DVATRLQMAY AGEKADAIQD KEREVSAAWQ ALLDACAGRR TQLVDTADKF RFFSMARDLL
SWMESIIRQI ETQERPRDVS SVELLMKYHQ GIRAEIETRS KNFNACLELG ESLLQREHQA
SEEIREKLQQ VMSRRKEMNE KWEARWERLS MLLEVCQFSR DASVAEAWLI AQEPYLASRD
FGHTVDSVEK LIKRHEAFEK STASWAERFA ALEKPTTLEL KERQIPEPPV EETGQKQPPA
SIPHCSLSSG QFPKGRRMEV KVWEENVGSQ ASILLSSRPR AEPQQGVLPL CAPEQGEEER
QWPQDLQPPP PPGPQKEGQE EKSGGDERPA TEPLKVLDTP LSEGDEPITL PAQQDHGHSV
QMEGYLGRKH DLEGPNKKAS NRSWNHLYCV LRNSELTFYK DAKNLALGVP YHGEEPLALR
HAICEIAANY KKKKHVFKLR LSNGSEWLFH GKDEEEMLSW LQGVSTAINE SQSIRVKAQS
LPLPSITGPD TSLGKKDKEK RFSFFPKKK
//
