ID G1P2I0_MYOLU Unreviewed; 346 AA.
AC G1P2I0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=KH-like RNA-binding domain-containing protein {ECO:0000259|Pfam:PF16005};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000004069.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000004069.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000004069.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the KHDC1 family.
CC {ECO:0000256|ARBA:ARBA00009081}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPE02019035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P2I0; -.
DR STRING; 59463.ENSMLUP00000004069; -.
DR Ensembl; ENSMLUT00000004471.2; ENSMLUP00000004069.2; ENSMLUG00000004469.2.
DR eggNOG; ENOG502QQIF; Eukaryota.
DR GeneTree; ENSGT00940000162601; -.
DR HOGENOM; CLU_050702_0_0_1; -.
DR InParanoid; G1P2I0; -.
DR OMA; LSKRPYW; -.
DR TreeFam; TF338690; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR CDD; cd12795; FILIA_N_like; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR031952; MOEP19_KH-like.
DR PANTHER; PTHR19447:SF15; KH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR19447; OOCYTE-EXPRESSED PROTEIN HOMOLOG-RELATED; 1.
DR Pfam; PF16005; MOEP19; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 29..113
FT /note="KH-like RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF16005"
FT REGION 140..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 346 AA; 38504 MW; 22DC569F95E51D66 CRC64;
MATTKRFPTL VQLEQRGGAP FQVLGDHAKQ PYWFHTEYLK SPKTVHLEAW LVEAIFGPGG
EHIPHVECVS QTLLRINQWD PEGEAEILIF GRPSYQKDVS KMIMNLAHYH RQLRAQGSGP
GIAEPRNFSA AVRVAALQAS PDKVRVAKSQ RSPDAVREKA TQRSPDAVRE KATQRSPDAV
REMGTQRSPD AAREKATQRS PDAVQAVREK ATQRSPDAVR EKATQRSPDA VLEKTTQRSP
DAVQEKGTQR SPDAVQEKAI QRSPDAVREK ATQRSPDAVR EKATQRSPDA VLEKTTQRSP
DAVQEKATQR SPDAVQEKAT QRSPDAVREK ATQRSPVWEA ATQLFP
//
