ID G1P2L5_MYOLU Unreviewed; 767 AA.
AC G1P2L5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=U3 small nucleolar RNA-associated protein 25 homolog {ECO:0000256|ARBA:ARBA00024421};
DE AltName: Full=UTP25 small subunit processor component {ECO:0000256|ARBA:ARBA00032325};
GN Name=UTP25 {ECO:0000313|Ensembl:ENSMLUP00000004107.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000004107.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000004107.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000004107.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the UTP25 family.
CC {ECO:0000256|ARBA:ARBA00009223}.
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DR EMBL; AAPE02020050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P2L5; -.
DR STRING; 59463.ENSMLUP00000004107; -.
DR Ensembl; ENSMLUT00000004515.2; ENSMLUP00000004107.2; ENSMLUG00000004515.2.
DR eggNOG; KOG2340; Eukaryota.
DR GeneTree; ENSGT00390000000709; -.
DR HOGENOM; CLU_018705_1_1_1; -.
DR InParanoid; G1P2L5; -.
DR OMA; KYFRQTI; -.
DR TreeFam; TF105930; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR GO; GO:0048568; P:embryonic organ development; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
DR GO; GO:1902570; P:protein localization to nucleolus; IEA:Ensembl.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010678; UTP25.
DR PANTHER; PTHR12933; ORF PROTEIN-RELATED; 1.
DR PANTHER; PTHR12933:SF0; U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG; 1.
DR Pfam; PF06862; UTP25; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT REGION 1..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..126
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 88187 MW; 7197732BF1D3ABD5 CRC64;
MGKRSSRSQS QLLSTLTKKQ KKHLRDFGEE HPFHDRVSSK EAKPQICQLL LKFESSDTSN
SESEAESEPE QVSGYHKLLA TLKNVSEEDE EEEEEEEEEE EEEEEEEEAL AEAEMNSEDA
DSDVSVEEET AAASAGMRES NVLPADPKEK DGDEPPGTSQ QESPEEFTDT KHESLFSLET
NFLEEESGGN CSLKGSQDPF LHHVNKELKE KEIQAIATNP KTTQELKWPT LGQLVFSSKF
QKLETFKPPK DLDLKALYLQ KPLESTWTKT NSQFLSGPQK SSSPFTPLQK ELFLIMNSYQ
DLFYPERTAL KNGEEIRHVY CLHAINHVLK ANAQVLGNNS RRRGRKLGVG DDDDFRDQGL
TRPKVLIVVP FREAALRVVQ LFISLLEGDS KKKIIVSNKK RFNGEYGSDP EERPPNLKRP
EDYEAVFVGN IDDHFRIGVA ILQRSIRLYA PFYSSDILIA SPLGLRTIIG AEGEKKRDFD
FLSSIELLII DQADIYLMQN WEHVLHLMNH MNLLPLDSHG VDFSRVRMWS LNNWSKYYRQ
TLLFGALQDA QINSVFNKYC VNVQGQVAVR NVPLTGSISH VLVQLPHVFQ RMEAENLASV
IDASRFNFFV NKILPQYRDA VMSHTLIYVP SYFDFVRLRN YFKKEDLNFT HICEYTQKSA
ISRARHFFLH GEKQFLLLTE RFHFYKRYTI KGIRNLIFYE LPTYPHFYSE VCNMLRAATR
GEEAAWTCTV LYSKYDAQRL AAVVGVERAA QMLQSKKNVH LFITGER
//
