ID G1P2X7_MYOLU Unreviewed; 203 AA.
AC G1P2X7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Synaptogyrin 4 {ECO:0000313|Ensembl:ENSMLUP00000004236.2};
GN Name=SYNGR4 {ECO:0000313|Ensembl:ENSMLUP00000004236.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000004236.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000004236.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000004236.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the synaptogyrin family.
CC {ECO:0000256|ARBA:ARBA00010252}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPE02066993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006109184.1; XM_006109122.1.
DR AlphaFoldDB; G1P2X7; -.
DR STRING; 59463.ENSMLUP00000004236; -.
DR Ensembl; ENSMLUT00000004654.2; ENSMLUP00000004236.2; ENSMLUG00000004659.2.
DR GeneID; 102431372; -.
DR KEGG; mlf:102431372; -.
DR CTD; 23546; -.
DR eggNOG; KOG4016; Eukaryota.
DR GeneTree; ENSGT00950000182935; -.
DR HOGENOM; CLU_1209470_0_0_1; -.
DR InParanoid; G1P2X7; -.
DR OMA; IWIFQAY; -.
DR OrthoDB; 4177492at2759; -.
DR TreeFam; TF320995; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR016579; Synaptogyrin.
DR PANTHER; PTHR10838; SYNAPTOGYRIN; 1.
DR PANTHER; PTHR10838:SF22; SYNAPTOGYRIN-4; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PIRSF; PIRSF011282; Synaptogyrin; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..138
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
SQ SEQUENCE 203 AA; 22009 MW; DD0DC96988BA82B9 CRC64;
IFALIVFSSL LTDGYQNKTD SSQLRCVLNS NNVACSFAVG AGFLALLSCL AFLALDAHEG
HIACTRFRTA FQLLDFILAV LWAGTWFLGF CFLANQWHRS PPKQFLLGNS SAKASVAFAF
FSVPIWIFQA YLAFQDLRND APVPYKRSLD EGGVVLTTLS PPSAASPINT PTTGPNSVSY
ASSALSPYLT TAKVPRLVMM PDN
//
