ID G1P376_MYOLU Unreviewed; 1511 AA.
AC G1P376;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Nucleoporin 153 {ECO:0000313|Ensembl:ENSMLUP00000004357.2};
GN Name=NUP153 {ECO:0000313|Ensembl:ENSMLUP00000004357.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000004357.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000004357.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000004357.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02023872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02023873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02023874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02023875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02023876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000004357; -.
DR Ensembl; ENSMLUT00000004785.2; ENSMLUP00000004357.2; ENSMLUG00000004775.2.
DR eggNOG; KOG4719; Eukaryota.
DR GeneTree; ENSGT00940000153253; -.
DR HOGENOM; CLU_004629_1_0_1; -.
DR InParanoid; G1P376; -.
DR OMA; SASEWEC; -.
DR TreeFam; TF323517; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0042405; C:nuclear inclusion body; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0034399; C:nuclear periphery; IEA:Ensembl.
DR GO; GO:0044615; C:nuclear pore nuclear basket; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IEA:Ensembl.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IEA:Ensembl.
DR GO; GO:0046832; P:negative regulation of RNA export from nucleus; IEA:Ensembl.
DR GO; GO:0051292; P:nuclear pore complex assembly; IEA:Ensembl.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 4.
DR InterPro; IPR026054; Nucleoporin.
DR InterPro; IPR013913; Nup153_N.
DR InterPro; IPR018892; Retro-transposon_transp_CS.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23193; NUCLEAR PORE COMPLEX PROTEIN NUP; 1.
DR PANTHER; PTHR23193:SF23; NUCLEAR PORE COMPLEX PROTEIN NUP153; 1.
DR Pfam; PF08604; Nup153; 2.
DR Pfam; PF10599; Nup_retrotrp_bd; 1.
DR Pfam; PF00641; zf-RanBP; 4.
DR SMART; SM00547; ZnF_RBZ; 4.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 4.
DR PROSITE; PS01358; ZF_RANBP2_1; 4.
DR PROSITE; PS50199; ZF_RANBP2_2; 4.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 695..725
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 760..789
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 830..860
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 889..918
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1274..1304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1352..1428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1454..1511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1461..1501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1511 AA; 158641 MW; 02EB9D9A66EFB3E8 CRC64;
MASEAGGIGG GGGGKIRTRR CHQGPIKPYQ QGRPKQQQGI LSRVTESVKN IVPGWLQRYF
NKNEDVCSCS ADTREVPQWP ENREDDHLIY ADEESANIHD GRITPEPTVS NTEEPSTTST
ASNYPDVLTR PSLHRSHLNF SMLESPTLHC QPSTSSAFPI GSSGFSLVKE IKDSTSQHDD
DNISTTSGFS SRASDKDITV SKNTSVLPLW SPEAERSHSL SQHTATSSKK PAFNLSAFGT
LSPSLGSSSF LKTSQLGDSP FYPGKTTYGG AAAAVRQPKL QNTPYQVPFR RQMKAKQVNA
EYYGVTSSTA RRILQSLEKM SSPLADAKRI PSVVSSPMNS PLDRRGIDNT TDFQAKREKV
VCQYPPVQRL MTPKPVSIAA NRTAYFKPSL TPSGELKKTN QRIDKKHSTG YEKSMTPGQN
REQESGFSYP NFSMSAANGV SSGVGGGGGK MRRERTRFVA TKPAEQEQKA IILLFLKLIF
SSCMRTIISL AVLKIFKINK EMEVPVLPNI SLPITSSSLP TFNFSSSVIT TSLSPISPAQ
SLTNKDSENQ VQMTSPNNTN SPMFRFSSPI VKSTEADVLP PSSIGFTFSV PVAKTVELSG
SSTVLEPITN SAAQDITAMN SRSCKKPDED SEGLFRPAKT LKEGSVLDVL KNPGFTSPKA
DSLAAISTTT SPVVYTRPAI SSFSSSGIGL GESLKAGSSW QCDSCLLQNK VTDSKCIACQ
ATKSPLRDTA KQTGIGTPSK SVKPTLSASG TGFGDKFKPA IGTWDCDTCL VRNKPEAIKC
VACETPKPGT GVKRVLTLPV ASESAVTVAA SSSSCTVTTG TLGFADKFTK PKRSWECPVC
CVPNNPEDNK CVSCMSEKPG SSVPASSSST VPISLSSGGC LGLDKFKKPE GSWECEVCLV
QNKADSTKCV ACESARPGTK SEFKGFGTSS SSSNPASSSF KFGILSSSSE PSQTLPSTGN
FKFGDQGGFK IGMSSDSGSL NPMSEGFKFS KPVGDFKFGV SSDSKPEEVK KDSKNDNNFK
FGLSSGLSNP ALAPFQFGMT NLGQQEKKEE LPKASSTGFS FGTGVINPTP AAADTVVTSE
NKSSFSFGTI ETKSSSVAPF PCKTSEAKKE EMPATKGGFP FGNMEPAPLP SASLFALGRT
EEKQEPVTST SLVFGKKADN EEPKCQPVFP FGNSEQTKDE SSSKSTFSFS MVKPSEKESE
QPAKATFAFG AQTSTTADQG GAKPVFSFLN NNSSNSSTPA TSAGGSIFGS STSSSSAPAS
AFVFGQANNP VSSSAFGNPA ESSTSQQSLL FPQESKPATT SSSGTAVTPF VFGPGASSNN
TATSGFNFGA TTTSSSSGCS FVFGTGPSAP SASPAFGANQ TPTFGQSQGA SQPNPPGFGS
LSSSAALFSA GSQPAPPTFG TVSSSSQPPV FGQQPGQSAF GSGTAPNSGS VFQFGSSTTN
FNFTNNSPSG VFKFGANPST PAAPAQPSGS GFPFNQPSAS FTVGSNGKNM FSSSGTSVSG
RKIKTAVRRR K
//
