ID G1P3P3_MYOLU Unreviewed; 226 AA.
AC G1P3P3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Phosphopantothenoylcysteine decarboxylase {ECO:0000313|Ensembl:ENSMLUP00000004548.2};
GN Name=PPCDC {ECO:0000313|Ensembl:ENSMLUP00000004548.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000004548.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000004548.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000004548.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the HFCD (homooligomeric flavin containing Cys
CC decarboxylase) superfamily. {ECO:0000256|ARBA:ARBA00038350}.
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DR EMBL; AAPE02015943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P3P3; -.
DR STRING; 59463.ENSMLUP00000004548; -.
DR Ensembl; ENSMLUT00000004987.2; ENSMLUP00000004548.2; ENSMLUG00000004993.2.
DR eggNOG; KOG0672; Eukaryota.
DR GeneTree; ENSGT00440000038107; -.
DR HOGENOM; CLU_033319_3_2_1; -.
DR InParanoid; G1P3P3; -.
DR OMA; KGLACGD; -.
DR TreeFam; TF315740; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0010181; F:FMN binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:Ensembl.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1950; Flavin prenyltransferase-like; 1.
DR InterPro; IPR036551; Flavin_trans-like.
DR InterPro; IPR003382; Flavoprotein.
DR PANTHER; PTHR14359; HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY; 1.
DR PANTHER; PTHR14359:SF6; PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE; 1.
DR Pfam; PF02441; Flavoprotein; 1.
DR SUPFAM; SSF52507; Homo-oligomeric flavin-containing Cys decarboxylases, HFCD; 1.
PE 3: Inferred from homology;
KW Coenzyme A biosynthesis {ECO:0000256|ARBA:ARBA00022993};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 36..211
FT /note="Flavoprotein"
FT /evidence="ECO:0000259|Pfam:PF02441"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 226 AA; 24521 MW; A2009A4725766D17 CRC64;
MEPSSGRLPG LEATRPHMEP RASCPAAAPS VERQFRVLVG VTGSVAALKL PLLVSQLLDI
PGLEVAVVTT ERAKHFYSPQ DIPVTLYSDA DEWEMWKCRS DPVLHIDLRR WADLMLVAPL
DANTLGKVAS GICDNLLTCV IRAWDRGKPL LFCPAMNTAM WEHPLTSQQV GQLQAFGYIE
IPCVAKKLVC GDQGLGAMAE VDTIVDKVKE VLSQHALSAG LNPGSL
//
