ID G1P5B1_MYOLU Unreviewed; 1670 AA.
AC G1P5B1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Alpha kinase 3 {ECO:0000313|Ensembl:ENSMLUP00000005189.2};
GN Name=ALPK3 {ECO:0000313|Ensembl:ENSMLUP00000005189.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000005189.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000005189.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000005189.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Alpha-type
CC protein kinase family. ALPK subfamily. {ECO:0000256|ARBA:ARBA00008651}.
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DR EMBL; AAPE02050466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02050467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02050468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000005189; -.
DR Ensembl; ENSMLUT00000005680.2; ENSMLUP00000005189.2; ENSMLUG00000005659.2.
DR eggNOG; ENOG502QPP5; Eukaryota.
DR GeneTree; ENSGT00940000158534; -.
DR InParanoid; G1P5B1; -.
DR OMA; WPPAINR; -.
DR TreeFam; TF332629; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0055013; P:cardiac muscle cell development; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR47091; ALPHA-PROTEIN KINASE 2-RELATED; 1.
DR PANTHER; PTHR47091:SF1; ALPHA-PROTEIN KINASE 3; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR Pfam; PF07679; I-set; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 70..166
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1240..1328
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1356..1590
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1593..1670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1126..1158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1611..1670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1670 AA; 177960 MW; D8C71D255D0B1871 CRC64;
GKGEGGQVGE WEGDGKDKGR KLWXPSPTSR SYLLGVRPET SLSSSRLSLP SSGRSTFCSI
IAQLTEETQP VFETTLKSQA VSKDSDVRFT CIITGYPEPE VTWYKDDTEL DRFCGLPKYE
ITHQGKRHTL QLYRCQEEDA AIYQASARNT KGIVSCSGVL EVGTMTEYKI HQRWFAKLKC
KAEAKMREIE QSWKRGKEVA GEADTLRKLS PDRFQRKRRL SGAEMPVPSA PTREAEDRTS
ATWQERETEP GQHPGLSLIN SFAPGEVTTN GDAVPENGED GDHGLLTYIC EAMELGPQRA
PQKELGAKKK KKVEEPKPGL RKPELEKAAR GDCSENCVPS SDKPDSCGTQ GPVDAEQIQT
WSRGRAARGP GSSGVESTRK PASAMGSPAQ AQNVPAPAPG PDQEVYFSLK DMYLESTQAV
RPQGEQGYHT QSGRESREMP SGKVPSEAKS EKGPPAPDQP IPSAPQPTRP FNRKRFAPPK
PKGEPTTNSK PDSSLNQAPE PGAQSLGNGP PQASAQVPTP PARRRHSTRD SPLQGQAGRR
TPGEVPESQA TMVPTVWASS SIGIASAGGS TPRSQSIIEP MDTETQESRT YADWRHGGMK
NTEADGKMQV DGRTQADRKT QMDIVTQESE RTESDRSSQK DVVAQGRTGT QAERTQEDRK
TQAGAKTQED RIQEGRGTQT EGSVPTTVKV QSEKKSVTNL SPQSRAPEPS PSEGSSSQII
ACFEQSPERS SVPEKPGFML RSGEAAETAS RNQEETVLGP LSGGLRLPAQ LLPESGLEQT
GGGRCWGPEW SGPVKDKPED SLFQCPKKEQ LGEVLSVDLG GCPPAGLSPD VPTLPSPAGA
GLTDSSPQGL PSTPTSQHMS AAAFLPSGDQ ALRNSAPSVH LGPGTPTQNH PPETIAASNE
GACAKMSDVE GRPSGTQSCD PGLIDSLKNY LLLLLKLSST ETSRGGTKSQ EAAAPRGLAP
SPTLAPTLEV AGLSPQTSRR ILERVENDHL VQSAQMLLLS PCTSRRITGL LDREVQAGQQ
ALAAARSPGS SPLTVPAIVV GEEEDPGLTS EGSSKGDGEV PLARSGLLGT SQESSAGGLL
GEAGGQAASG QGPLSAESRV QDPSREEEIP QEAPAGLPAA TPEELALGAR RKRFLPKARA
AGDGEATKPE ERESPTVSPR GPRKGLSPGS PGTLGREKRS PTQGRKAGLL EVPQAEEEQA
AGDLGSSPKP SGLDAEPTLD EGKQETPGKP RKAKDLLKAP QVIRKIRVEQ FPDASGSLKL
WCQFFNILSD SVLTWAKDLH PVGEVGRSAG DEGPAALAIV QASPGDCGMY RCTIHNEHGS
ASTDFCLSPE VLSGFISREE GEVGEEIEMT PMVFAKGLAD SGCWGDKLFG RLVSEDLRGG
GHRYSLRKAS QAKVIYGLEP IFESGRTCVI KVSSPLVFGP SSETSLLGRN YDVTIQGCKI
QNMSREYCKI FAAEARAAPG FGEVPEIIPL YLIYRPANNI PYATLEEDLG KPLEPYCSRE
WGCAAAPASG SSEAVQKCQA FQHWLYLWTN GSFLVTDLAG VDWKMTDVQI ATKLRGYQGL
KESCFPALLD QFASSHKCNT FCEMLGLKPL KGPEAAHSQV KAKGSKSPSA GRKGPQLSPQ
PQKKGLPSPQ GSRKSTPSSK ATPQASGAVA TQLLGQPPSQ EGGSKAQGTR
//
