ID G1P5D5_MYOLU Unreviewed; 1943 AA.
AC G1P5D5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN Name=CACNA1F {ECO:0000313|Ensembl:ENSMLUP00000005214.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000005214.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000005214.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000005214.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; AAPE02033831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02033832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000005214; -.
DR Ensembl; ENSMLUT00000005706.2; ENSMLUP00000005214.2; ENSMLUG00000005694.2.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000159855; -.
DR HOGENOM; CLU_000540_0_1_1; -.
DR InParanoid; G1P5D5; -.
DR OMA; VCTLNQT; -.
DR TreeFam; TF312805; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR GO; GO:0050908; P:detection of light stimulus involved in visual perception; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF2; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 55..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 836..854
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 874..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 906..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 952..981
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1081..1104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1155..1176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1188..1207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1290..1308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1381..1405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1540..1574
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 419..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1601..1718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1784..1807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..792
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1602..1624
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1630..1647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1667..1682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 292
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 673
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1050
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 1943 AA; 217488 MW; DAFA94BF7B38085B CRC64;
ASGLGTPKRR TQHSKHKTVA VASVQRSPRA IFCLTLANPL RQSCISIVEW KPFDILILLT
IFANCVALGV YIPFPEDDSN TANHNLEQVE YVFLVIFTVE TVLKIVAYGL VLHPSAYIRN
GWNLLDFIIV VVGLFSVLLE QGPGRPGDAP HTGGKPGGFD VKALRAFRVL RPLRLVSGVP
SLHIVLNSIM KALVPLLHIA LLVLFVIIIY AIIGLELFLG RMHKTCYFLG SEMEAEEDPS
PCASSGSGGS GRVCTLNQTE CRGRWAGPNG GITNFDNFFF AMLTVFQCVT MEGWTDVLYW
MQDAMGYELP WVYFVSLVIF GSFFVLNLVL GVLSGEFSKE REKAKARGDF QKLREKQQLE
EDLRGYLDWI MQAEELDMED PSADGNFGSV AEEGRAGHRP QLAELTNRRH GRLHWFSHST
RSTHSTSSHA SLPASDTGSM AETPGDEEEE EGALASCTRC LNKIMKTRVC RRLRRVNQGL
RACCRRAVKS NACYWAVLLL VFLNTLTIAS EHHGQPMWLT QTQEYANKVL LCLFTVEMLL
KLYGLGPSTY VSSFFNRFDC FVVCGGILET TLVEVGAMQS LGISVLRCVR LLRIFKVTRH
WASLSNLVAS LLNSMKSIAS LLLLLFLFII IFSLLGMQLF GGKFNFDQTH TKRSTFDTFP
QALLTVFQIL TGEDWNVVMY DGIMAYGGPF FPGMLVCVYF IILFICGNYI LLNVFLAIAV
DNLASGDTGT AKNKGREKST EGKHPQENGA LVPGGENEKE EGAKNEGADL VVPGMEEEEE
EEEEEEEEEG AGRVELLQEV VPKEKVVPIP EGSAFFCLSQ TNPMRKACHT LIHHHVFTNL
ILVFIILSSV SLAAEDPIRV HSFRNHILGY FDYAFTSIFT VEILLKMTVF GAFLHQGSFC
RSWFNLLDLL VVSVSLISFG IHSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA
IRTIGNIMIV TTLLQFMFAC IGVQLFKGKF YSCTDEAKHT PKECKGSFLV YPDGDVSRPR
VRERLWVNSD FNFDNVLSAM MALFTVSTFE DWPALLYKAI DAHAEDQGPI YNYHVEISVF
FIVYIIIIAF FMMNIFVGFV IITFRAQGEQ EYQNCELDKN QRQCVEYALK AQPLRRYIPK
NPHQYRVWAT VNSAAFEYLM FLLILLNTVA LAMQHYEQTA PFNYAMDILN MVFTGLFTVE
MVLKIIAFKP KHYFADAWNT FDALIVVGSV VDIAVTEVNN GGHLGESSED SSRISITFFR
LFRVMRLVKL LSKGEGIRTL LWTFIKSFQA LPYVALLIAM IFFIYAVIGM QMFGKVALQD
GTQINRNNNF QTFPQAVLLL FRCATGEAWQ EIMLATLPGN RCDPESDFGP GEEFTCGSNF
AIAYFISFFM LCAFLIINLF VAVIMDNFDY LTRDWSILGP HHLDEFKRIW SEYDPGAKGR
IKHLDVVALL RRIQPPLGFG KLCPHRVACK RLVAMNMPLN SDGTVTFNAT LFALVRTSLK
IKTEAGNLEQ ANQELRIVIK KIWKRMKQKL LDEVIPPADE EEVTVGKFYA TFLIQDYFRK
FRRRKEKGLL GTEASPSTFS VLQAGLRSLQ DLVPEIRQAL TCDIDEEEEE EGQGREEEED
EKDPETYQAP MGSQPPSRRS SLISVSLPTG DKLPDSLSLG PSDDDAGAPN SRQSSVPQAG
SHAHRRSSGA LIFTIPEEGS FQPKGTEGQE KQYEEEEVPG QGSYLHEQAA TPSCPILLPP
HRPQRYMDGH YAPRRRLLPP TPAGRKPSFT IQCLRRQGSC EDLPIPGTYH RGRNSGPSRA
QGSWATPPQR GRLLYAPLFL VEEGAAGERY LSKSSGPLCT FTCLQVPGTH SDPSHGKRGS
ADSLVEAVLI SEGLDLFARD PRFVALAKQE IADACRLTLD EMDSAASDLL AQRTSSLYSD
EESILSRFDE EDLGDEMACV HAL
//
