ID G1P6N0_MYOLU Unreviewed; 1821 AA.
AC G1P6N0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Golgi brefeldin A resistant guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSMLUP00000005732.2};
GN Name=GBF1 {ECO:0000313|Ensembl:ENSMLUP00000005732.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000005732.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000005732.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000005732.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
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DR EMBL; AAPE02031081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02031082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000005732; -.
DR Ensembl; ENSMLUT00000006278.2; ENSMLUP00000005732.2; ENSMLUG00000006247.2.
DR eggNOG; KOG0928; Eukaryota.
DR GeneTree; ENSGT00940000156925; -.
DR HOGENOM; CLU_001204_2_0_1; -.
DR InParanoid; G1P6N0; -.
DR OMA; CRDIRHH; -.
DR TreeFam; TF105934; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0051641; P:cellular localization; IEA:UniProt.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF388; GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 648..838
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 173..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1240..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1392..1444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1687..1769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1255..1275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1736..1756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1821 AA; 202054 MW; CFCAFB78B97C6247 CRC64;
HLFIPLSFLA ELSEIEPNVF LRPFLEVIRS EDTTGPITGL ALTSVNKFLS YALIDPTHEG
TAEGMENMAD AVTHARFVGT DPASDEVVLM KILQVLRTLL LTPVGAHLTN ESVCEIMQSC
FRICFEMRLS ELLRKSAEHT LVDMVQLLFT RLPQFKEEPK NYVGTNMKKL KMRAGGMSDS
SKWKKQKRSP RPPRHMTKVI PGSELPISNG TTLSSNFTGG MPFIDVPTPI SSASSEAASA
VVSPSTDSGL EFSSQTTSKE DLTDLEQPGS SGYSTATEPG SSELGVPEQP DSQEGAHVEK
AQSASVESIP EVLEECTSPV DHSDSASVHD MDYVNPRGVR FTQSSQKEGT ALVPYGLPCI
RELFRFLISL TNPHDRHNSE VMIHMGLHLL TVALESAPVA QCQTLLGLIK DEMCRHLFQL
LSIERMNLYA ASLRVCFLLF ESMREHLKFQ LEMYIKKLME IITMENPKMP YEMKEMALEA
IVQLWHIPSF VTELYINYDC DYYCSNLFED LTKLLSKNAF PVSGQLYTTH LLSLDALLTV
IDSTEAHCQA KVLNNLTQQE KKEAARPSYE AVDGTREVSN TERAASDGKA VGMAPDILGL
HLPGGGRLPA EHGKPGCNDL EEAGDSGADK KYTRKPPRFS CLLPDPRELI EIKNKKKLLI
TGTEQFNQKP KKGIQFLQEK GLLTIPMDNT EVAQWLRENP RLDKKMIGEF VSDRKNIDLL
ESFVSTFSFQ GLRLDEALRL YLEAFRLPGE APVIQRLLEA FTEHWRNCNG SPFANSDACF
ALAYAVIMLN TDQHNHNVRK QNAPMTLEEF RKNLKGVNGG KDFEQDILED MYHAIKNEEI
VMPEEQTGLV RENYVWNVLL HRGATPEGIF LRVPAGSYDL DLFTMTWGPT IAALSYVFDK
SLEETIIQKA ISGFRKCAMI SAHYGLSDVF DNLIISLCKF TALSSESIEN LPSVFGSNPK
AHIAAKTVFH LAHRHGDILR EGWKNIMEAM LQLFRAQLLP KAMVEVEDFV DPNGKISLLR
EEIPSNRGES TVLSFVSWLT LSGTEQSSVR GPSTENQEAK RVALECIKQC DPEKMITESK
FLQLESLQEL MKALVSVTPD EETYDEEDAA FCLEMLLRIV LENRDRVGCV WQTVRDHLYH
LCVQAQDFCF LVDRAVVGLL RLAIRLLRRE EISGQVLLSL RILLLMKPSV LSRVSHQVAF
GLHELLKTNA ANIHSGDDWA TLFTLLECIG SGVKPPAALQ ATTRADAPDA GSGAQSDSEL
PSYHQNDTSL DRGYTSDSEV YADHGRPGKI HRSATDADVV NSGWLVVGKD DIDNSKPGLG
TGSSRPGPSP LVNQYSLTVG LDLGPHDTKS LLKCVESLSF IVRDAAHITP DNFELCVKTL
RIFVEASLNG GCKSQEKRGK SHKYDSKGNR FKKKSKEGSV LRRPRTSSQH ATRGGHSDDD
EDEGVPVSYH TVSLQVSQDL LDLMHTLHIR AASIYSSWAE EQRHLETSGQ KIEADSRTLW
AHCWCPLLQG IACLCCDARR QVRMQALTYL QRALLVHDLQ KLDALEWESC FNKVLFPLLT
KLLENISPAD VGGMEETRMR ASTLLSKVFL QHLSPLLSLS TFAALWLTIL DFMDKYMHAG
SSDLLSEAIP ESLKNMLLVM DTAEIFHSAD ARGGSPSALW EITWERIDCF LPHLRDELFK
QTVIQDPTPM EPHAQKPLPS AHLTPTAGDT RTPGHPLLPE MPSELGACDF EKSEGPRPGN
SSSPGSPVAS SPSRLSPTPD GPLPLAQPPL ILQPLASPLQ VGVPPMTLPI ILNPALIEAT
SPVPLLATPR PTDPMPTSEV N
//
