ID G1P705_MYOLU Unreviewed; 854 AA.
AC G1P705;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Contactin 4 {ECO:0000313|Ensembl:ENSMLUP00000005874.2};
GN Name=CNTN4 {ECO:0000313|Ensembl:ENSMLUP00000005874.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000005874.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000005874.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000005874.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with PTPRG. {ECO:0000256|ARBA:ARBA00038703}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. Contactin
CC family. {ECO:0000256|ARBA:ARBA00009812}.
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DR EMBL; AAPE02040866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02040867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P705; -.
DR STRING; 59463.ENSMLUP00000005874; -.
DR Ensembl; ENSMLUT00000006432.2; ENSMLUP00000005874.2; ENSMLUG00000006418.2.
DR eggNOG; KOG3513; Eukaryota.
DR GeneTree; ENSGT00940000155198; -.
DR HOGENOM; CLU_005756_0_0_1; -.
DR InParanoid; G1P705; -.
DR OMA; EESIFWE; -.
DR TreeFam; TF351103; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR CDD; cd00063; FN3; 4.
DR CDD; cd04969; Ig5_Contactin; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF18; CONTACTIN 4-RELATED; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..854
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003417446"
FT DOMAIN 1..77
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 89..175
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 180..264
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 270..357
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 361..450
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 463..561
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 566..663
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 668..763
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 765..854
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 547..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 854 AA; 93926 MW; B7FD43C63DC07919 CRC64;
SCWKLVFHGL SLWSTELSYA WIFNEYPSYQ DNRRFVSQET GNLYIAKVEK SDVGNYTCVV
TNTVTNHKVL GPPTPLTLRN DGVMGEYEPK IEVQFPDTVP TAKGGTARLE CFALGNPVPT
IVWRRADGKP IARKARRHQS DGILEIPNFQ QEDAGLYECV AENSRGKNVA RGQLTFYAQP
NWIQKISNIH VAIEDSVSWE CRASGRPRPT YRWLKNGEPL FAQDRVHIEQ GSLNITGVSL
ADAGMYQCVA ENRHGAVFSS AELSVIAAGP DFSRTLLKRV TLVKVGGDVV IECKPKASPK
PIYTWKKGRA VLRESERITI SEDGSLRIVN VTKADAGSYT CVATNHFGTA SSTGSLVVKD
PTRVTVPPAS MDVTVGESIV LTCQVRQDHS LDIVFTWSFN GHRIDFNRDG DHFERVGGQD
SAGDLMIRNI QLKHAGKYVC TVQTSVDQLS AAADLIVRGP PGPPEAVTID EITDTTAQLS
WSPGPDNHSP VTLYVVQART PFSVGWQAVS TVPDVIDGRT FTATVVGLNP WVEYEFRTVA
ANAIGIGEPS PPSEKRRTEE ALPEVTPANV SGGGGSKSEL VITWETVPEE LQNGRGFGYV
VAFRPHGTVI WMLTVLASAD ACRYVFRNES VRPFSPFEVR VGVYNNKGEG PFSPIVVVYS
AEEEPTRPPA SISARSLSAT DVEVVWASPQ ERNRGRIQGY EVKYWRHDDK EENARKIRTF
GNQTSTKITN LQGSALYHLA VKAYNTAGTG PSSATVNVTT RKPPPSQAPG NVVWNSSDSK
IVLNWDQVKA LENESDVRGY KVLYRWSRQS RTSVIETNQT SVELSLPLDE DYIIEIRPVS
DGGDGSASQQ IRIP
//
