ID G1P748_MYOLU Unreviewed; 842 AA.
AC G1P748;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Colony stimulating factor 3 receptor {ECO:0000313|Ensembl:ENSMLUP00000005924.2};
GN Name=CSF3R {ECO:0000313|Ensembl:ENSMLUP00000005924.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000005924.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000005924.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000005924.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; AAPE02028125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02028126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02028127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006094202.1; XM_006094140.2.
DR RefSeq; XP_014315902.1; XM_014460416.1.
DR RefSeq; XP_014315903.1; XM_014460417.1.
DR AlphaFoldDB; G1P748; -.
DR STRING; 59463.ENSMLUP00000005924; -.
DR Ensembl; ENSMLUT00000006487.2; ENSMLUP00000005924.2; ENSMLUG00000006479.2.
DR GeneID; 102427246; -.
DR KEGG; mlf:102427246; -.
DR CTD; 1441; -.
DR eggNOG; ENOG502QT3H; Eukaryota.
DR GeneTree; ENSGT00940000158915; -.
DR HOGENOM; CLU_017990_0_0_1; -.
DR InParanoid; G1P748; -.
DR OMA; SYCSIPR; -.
DR OrthoDB; 5354422at2759; -.
DR TreeFam; TF338122; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF103; GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 629..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 237..332
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 434..528
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 530..625
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 842 AA; 93148 MW; 208A864CC1CA9253 CRC64;
MVVGLGTWSL ARAALIILLL PRSLEECGRI SVSAPIVHLG DAITASCIIN RTCSHLDPES
QIVWKLGTEL QPGGRQQRLP DGTQESTITL PHLNDSRALL SCCLRWGNSL QILDQAELQA
GYPPATPHNL SCLMNLTIES LICQWEPGPD THLSTNFTLK SFKSRGNCQD QEEAIPDCVP
EDGQSRCSIP RKHLRLYQSM GLWVQAENVL GTSVSPQLCL DPMDVVKLEP PTLWALDPSP
EVAPPQPGCL QLHWESWKST QYIDQKCELR HQPQPGGANW TLVGPLPSKT LQHELCGLLP
STAYSLQMRC TRWPLPGHWS DWSPSLELTS AQQAPNVRLD TWWRQRQLDR RTVDMQLFWK
PMPVEEDSGQ IQGYLVSWRP SGQAGAVPPL CNTTELNCTF HLPSEVREVV LVAYNTAGTS
RPTPVVFLES TGPPLGRLHT MARDPHSLWV GWEPPSPRPR GYVIEWGPGP PSPSGSHMTW
KMEHNGSIAG TLLQENIRPF QLYEITVTTL YQDTVGPSQR IYAYSQETAP SYTPELHLKH
IGKTWAQLEW VPPTPELGRS PLTHYTIFWT NAQGQSFSTI LNASSHEFVL PGLEPASLYH
VHLMAASQVG ATNSTSLTLM TLAPGEFELH IFLGLFGLLL SLICLCVATR FCCRPSRKNS
LWPSVPDPAH SSLGSWVPSI PAEEIFQLPS LWDTSMPPIT KITVLEEEEK KPGPWESHES
SGTCGLPALV QAYVLQGDPR ASTIQPQTQS GNTDQVLYGQ VMGSPSRSGP ADYIRCDSTQ
PLLGDLTPSP KSYENLWFQT SPQRTPEPLV PNQEDDCVFG PLLDFPLLQG LQVHGVEGLG
GF
//