ID G1P8Z7_MYOLU Unreviewed; 948 AA.
AC G1P8Z7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091};
GN Name=CNNM1 {ECO:0000313|Ensembl:ENSMLUP00000006672.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000006672.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000006672.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000006672.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369091};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000256|ARBA:ARBA00010484,
CC ECO:0000256|RuleBase:RU369091}.
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DR EMBL; AAPE02020074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02020075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P8Z7; -.
DR STRING; 59463.ENSMLUP00000006672; -.
DR Ensembl; ENSMLUT00000007312.2; ENSMLUP00000006672.2; ENSMLUG00000007307.2.
DR eggNOG; KOG2118; Eukaryota.
DR GeneTree; ENSGT00940000157525; -.
DR HOGENOM; CLU_011310_1_1_1; -.
DR InParanoid; G1P8Z7; -.
DR OMA; RQNSECC; -.
DR TreeFam; TF101012; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF28; METAL TRANSPORTER CNNM1; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT DOMAIN 216..412
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 500..566
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 115..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 948 AA; 103944 MW; 602688D9C90EE934 CRC64;
CRMAAAAAAV GVRLRDCCSR GAVLLLFFSL SPRPPAAAAW LLGLRPEDTA GGRVSLEGGT
LRAAEGTSFL LRVYFQPGPA APAALVPVPT LSSGENGTGD LAPRLVFIEE PPGGSGLAPS
AVPTRPPGPQ RCREQSDWAS DVEVLGPLRP GGVAGSALVQ VRVRELRKGE ADKGGAGGGG
EPLLAVRPGD GRSWDHHGAG GFLLRVRPRL YGPEGLLTPA WLRALGALLL LALSALFSGL
RLSLLSLDPV ELRVLRNSGS ATEQEQARRV QAVRGRGTHL LCTLLLGQAG ANAVLAGWLY
TSLPPGVGDP GEDYGEAGIH FPWLPALVCT GAVFLGAEIC PYSVCSRHGL AIASHSVCLT
RLLMAAAFPV CYPLGRLLDW ALRQEISTFY TREKLLETLR AADPYNDLVK EELNIIQGAL
ELRTKVVEEV LTPLGDCFML RSDAVLDFST VSEILRSGYT RIPVYEGDQR HNIVDILFVK
DLAFVDPDDC TPLLTVTRFY NRPLHCVFND TRLDTVLEEF KKGKSHLAIV QRVNNEGEGD
PFYEVMGIVT LEDIIEEIIK SEILDETDLY TDNRKKQRVP HRERKRHDFS LFKLSDSEMR
VKVSPQLLLA THRFMATEVE PFKSLYLSEK ILLRLLKHPH VIQELKFDDK NKKAPEHYLY
QRSRPVDYFV LLLQGKVEVE VGKEGLRFEN GAFTYYGVPA IMTTSCSDND VRKAGSLAGS
SAFLNRSPSR CSGLNRSESP NRERSDFGGS NTQLCSSNNL YTPDYSVHIL SDVQFVKITR
QQYQNALTAC HMDNSPQSPD MEAFTDGDST KAPTTRGTPQ TPKDDPAVIL LNNRNSLPCS
RSDGLRSPGE VVYLRMEEMG FTQEDMTDFQ EHSTQQLSVS PAAIPTRAAS DSECCNINLD
TETSPCSSDF EETMGKRLLR TLSGRKRKRS PDGERASEEN SNLTPLIT
//
