ID G1P9P6_MYOLU Unreviewed; 4025 AA.
AC G1P9P6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Dynein axonemal heavy chain 7 {ECO:0000313|Ensembl:ENSMLUP00000006964.2};
GN Name=DNAH7 {ECO:0000313|Ensembl:ENSMLUP00000006964.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000006964.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000006964.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000006964.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AAPE02003053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02003054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02003055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02003056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02003057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02003058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000006964; -.
DR Ensembl; ENSMLUT00000007629.2; ENSMLUP00000006964.2; ENSMLUG00000007538.2.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000155282; -.
DR HOGENOM; CLU_000038_0_0_1; -.
DR InParanoid; G1P9P6; -.
DR OMA; GRDIPCS; -.
DR TreeFam; TF316836; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0036156; C:inner dynein arm; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0003341; P:cilium movement; IEA:Ensembl.
DR GO; GO:0036159; P:inner dynein arm assembly; IEA:Ensembl.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF18; DYNEIN AXONEMAL HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 2244..2279
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2835..2883
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 28..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4025 AA; 461285 MW; C190927CF175C7C5 CRC64;
MFFMQDKSPS KEKSKIPLRF LPQSSMEKPA SKEKDKDKGK FPARLLPQLA TVSTKPQWQE
AAPSFHLNIK QEEEIPEPFS VKNEQSYAEY MEQFGRKGTL LDQIDDSRAG PSTSKAKTKS
PHKERENFRS TLVNVIMQQD ALSDVPAPDE SAFPKMTTSA IEKDILRYYY YIHHGIDTDH
IAPMEDAWLE NVLNLVPQHL KVLTDSILTL SDEMREDYLL SVKKSIVDFV LKDPREKDDK
KTEELPPHRA EMEILPKPWR KSFLAASSYI RDHLNAMNPT MLAVLDLWNS TFKKLRLIDT
EEFHNRQEAL EISYLPDIYL TYTVDTCKDT WPSLWFPEVQ NIYYQGNKKK QLPTGESSAK
LESFFNCAAA LMTLQLQDLT LASMQDFTDL VAQPPDSVRA FEHPGFIVRL LLDNDTIKFE
PQFEDYIDIF LNIYDVMIKA VSFVPRVETK LYSKWDSNSK PTTLAPVILD EIIEAHKEKV
KEVILRESAA PIEHLKLYNK YDFLITRKAE RDVDAFLAEN HHYEKIIQEI RKYQQLIEDI
QYTTRKTVRL GMFEVRCEDL IRALVKRAEV ICGKLVAKMF RDHQEVNTRL CDEFEKIAEK
ALSTPPNTAE LMEMKAYIKK VETVDMIELG RRLVDSKNCL AFLIECATFS PADIRLNNNV
FQWYGRMEEI FEEHRRIIAD KTEQYQDGLK LRCQRFVEEL ESYAKQSEEF YSLGDLQDVQ
RYLKKAQTLN GKLDLAADKI EQFNAEEEAF GWPPSLYPQR KKIQDSLNPY LRLYETAVEF
SNKYRAWTEG PYHKVDPDQV EVDVGNYWRG LYKLEKTFND SPNALAMTKK VKAKVEDFKQ
HIPLIQVICN PGLRPRHWEA MSNIVGFPLQ PADESTVSPF LDMNLEPYLD RFEGISEAAS
KEYTLEKTLE KMIKEWDSME FVLLSYRESG TSILSSVDEI QMLLDDHIIK TQTMRGSPFI
KPYEKQIREW EAKLLLLQEI LDEWLKVQAT WLYLEPIFSS PDIMSQMPEE GRRFTTVDKT
WRDIMKTILQ DKHVLSVVTI DRMLERLKKS NELLELILKG LNEYLEKKRL FFPRFFFLSN
DELLEILSET KDPTRVQPHL KKCFEGIARV EFTETLDITH MKSSENEVVE LIETISTVKA
RGQVEKWLVE LERVMIRSIQ KVIKSAIIAY TQYERIKWVR VWPGQTVLCV SQTYWTTEVQ
AAISKGQEAL EEYLEKCNRQ IDDIVTLVRG KLSKQNRVTL GALVVLDVHA RDVLTSLVNK
KVSDESDFEW LSQLRYYWQD NNLETKMINA GLRYGYEYLG NSPRLVITPL TDRCYRTLFG
ALHLHLGGAP EGPAGTGKTE TTKDLAKAVA KQCVVFNCSD GLDYLALGKF FKGLLSCGAW
ACFDEFNRID LEVLSVVAQQ ILTIQRGINA GADTLIFEGT ELKLDPTCAV FITMNPGYAG
RSELPDNLKA LFRTVAMMVP DYAMIAEIVL YSCGFVTARP LSVKIVATYR LCSEQLSSQH
HYDYGMRAVK SVLTAAGNLK LKYPHENEEI LLLRSIIDVN LPKFLSHDLP LFEGITSDLF
PGVKLPKPDY NDLLMAIKDN CEAMNLQMTG FFSEKILQIY EMMIVRHGFM IVGEPFGGKT
SAYRVLAGAL SDICEKGLME ENKVQITVLN PKSVTMGQLY GQFDQVSHEW SDGVLAVSFR
AFASSMTPDR KWLVFDGPVD AVWIENMNTV LDDNKKLCLM SGEIIQMSPQ MNLIFEPMDL
EVASPATVSR CGMIYMEPHM LGWRPLMMSW VNLLPATLNA TQKEFLVTLF DRMIPVSVEF
IRKHTKELSP TSDTNLVRSL MNLIDCFMDE FADEVNVRER NDREAYSLLE GIFIFSLIWS
VGASCTDDDR LKFNKILREL MEGPISDATR NRFKILSSVE QTSSKALTVP FPEKKTIYDY
QFVTEGIGRW EPWIKKLADA PPISKDMLFN EIIVPTLDTI RYSALMDLLT THQKPTIFVG
PTGTGKSSYI INFLLTQINK EIYKPLLINF SAQTTAAQTQ NIIMSKLDKR RKGVFGPPLG
KKMVVFVDDV NMPAREVYGA QPPIELLRQW LDHWNWYDLK DCSMIKLVDV QIMCAMGPPG
GGRNPVTPRF MRHFNVITIN EFSDKSMYTI FSRILNWHLK TCYKFPEDFL TLTAQIVNGT
MILYKEAMKN LLPTPAKSHY LFNLRDFSRV IQGICLSRPE TTATKEAIKR LWVHEVLRVY
YDRLLDNADR HWLIEYIQEI LTSHMYENFH ELFQHLDFNG DGIVEEDDLR SLMFCDFHDP
KKEDTNYREV ENVDNLRMIV ETHLEEYNNM SKKTMSLVLF RFAIEHISRI SRILKQPRSH
ALLVGVGGSG RQSVTRLATH MADYSIFQVE ITKGYGNTEW HEDLKVILRK CAEGEMQGVF
LFTDTQIKRE SFLEDVNNLL NAGEVPNLFP LDEKQEICEK MRQLDRQRDK TKQTDGSPIA
LFNMFIDRCR NQLHVVLAMS PIGDAFRIRL RKFPALVNCC TIDWFQSWPE DALQAVASRF
LEEIEMSEEI RDGCIDMCKS FHTSTIELST SFHVELQRYN YVTPTSYLEL ISTFKLLLEN
KRSEVMKMKK RYEVGLEKLD SAASQVASMQ LELEALHPQL KVASKAVDEM MLMIERESFE
VAKTEKIVKA DEIVANEQAM AAKAIKDECD ADLAGALPIL ESALAALDTL TAQDITVVKS
MKSPPAGVKL VMEAICILKG IKSDKIPDPT GSGKKIEDFW GPAKRLLGDI RFLQSLHEYD
KDNIPPAYMN IIRKNYIPNP DFVPEKIRNA STAAEGLCKW VIAMDSYDKV AKIVAPKKIK
LAAAEGELKV AMDGLRKKQA ALHEVQDKLA KLQDKLEQNK EKKADLENQV DLCSKKLERA
EQLIGGLGGE KTRWSQSALE LGLLYINLTG DILISSGVVA YLGAFTSNYR QNQVKEWTDL
CKGRGIPCSE DFSLMGILGE AVTIRTWNIA GLPSDSFSID NGIITMNARR WPLMIDPQGQ
ANKWIKNMEK TNSLQLIKFS EPDYVRTLEN CIQFGTPVLL ENVGEELDPI LEPLLLKQTF
KQGGSTCIRL GDSTEYAPDF RFYITTKLRN PHYLPETSVK VTLLNFMITS EGMQDQLLGI
VVARERPDLE EEKQALILQG AENKRQLKEI EDKILEVLSS SEGNILEDET AIKILSSSKA
LANEISQKQE VAEETERQID TTRMGYRPIA VHSTILFFSI ADLASIEPMY QYSLTWFINL
FILSIENSEN SDILTKRLQI LRDHFTYSLY VNVCRSLFEK DKLLFSFCLT VNLQIHEHAI
NKVEWRFLLT GGIGLDNPYT NPCTWLPQKS WDEICRLDEL PSFKAIRKEF MHLKEGWKRV
YDSLEPHHEA FPEAWEDKMN DFQRMLIVRC LRPDKVNIPS LFSVFLRELG RGFVYSPPRR
SPPISCSNTL APSCNSPSGS PRAPLAKGVH PQGYGGAKLS SLSLGQGQGP IAMKMLEKAV
KEGTWVVLQN CHLATSWMPT LEKVCEELSP ESTHPDFRMW LTSYPSPNFP VAVLQNGVKM
TNEAPKGLRA NIIRSYLMDP ISDPEFFGSC KKPAEFKKLL YGLCFFHALV QERRKFGPLG
WNIPYEFNET DLRISVQQLH MFLNQYEELP YDALRYMTGE CNYGGRVTDD WDRRTLRSIL
NKFFCAQLVE DPGYKFDSSG IYFAPPPGEH KSYIEYTQTL PLTPAPEIFG MNANADITKD
QSETQLLFDN ILLTQSRSAE AGAKSSEEVV NEVAGDILGK LPNNFDLEAA MRRYPTTYTQ
SMNTVLVQEM GRFNKLLQTI RESCINIQKA IKGLLVMSTD LEEVVSSILN VKIPGMWMAK
SYPSLKPLGS YVNDFLTRLR FLQQWYEVGP PPSFWLSGFF FTQAFLTGAQ QNFARKYTIP
IDLLGFDYEV LEDKDYKVPP EDGVLIYGLF LDGASWNRKI KKLAESHPKI LYDIVPVMWL
KPCRRTEIPK RPSYVAPLYK TSERRGTLST TGHSTNFVIA MTLPSDHPKE HWIGRGVALL
CQLNA
//