ID G1PBU1_MYOLU Unreviewed; 449 AA.
AC G1PBU1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Interferon gamma receptor 1 {ECO:0000313|Ensembl:ENSMLUP00000007849.2};
GN Name=IFNGR1 {ECO:0000313|Ensembl:ENSMLUP00000007849.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000007849.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000007849.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000007849.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC {ECO:0000256|ARBA:ARBA00005399}.
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DR EMBL; AAPE02007432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PBU1; -.
DR STRING; 59463.ENSMLUP00000007849; -.
DR Ensembl; ENSMLUT00000008611.2; ENSMLUP00000007849.2; ENSMLUG00000008601.2.
DR eggNOG; ENOG502RXGW; Eukaryota.
DR GeneTree; ENSGT00510000048929; -.
DR HOGENOM; CLU_043814_0_0_1; -.
DR InParanoid; G1PBU1; -.
DR OMA; NIMLPKS; -.
DR TreeFam; TF338358; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019955; F:cytokine binding; IEA:InterPro.
DR GO; GO:0004906; F:type II interferon receptor activity; IEA:Ensembl.
DR GO; GO:0038196; P:type III interferon-mediated signaling pathway; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR021126; IFN_gamma_rc_D2_pox/mammal.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008355; Interferon_gamma_rcpt_asu.
DR PANTHER; PTHR20859:SF5; INTERFERON GAMMA RECEPTOR 1; 1.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR Pfam; PF07140; IFNGR1_D2; 1.
DR Pfam; PF20634; IFNGR1_transm; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR PRINTS; PR01777; INTERFERONGR.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 219..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..84
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF01108"
FT DOMAIN 104..208
FT /note="Interferon gamma receptor D2"
FT /evidence="ECO:0000259|Pfam:PF07140"
FT REGION 307..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 49867 MW; 715217CEDB6238BF CRC64;
TVPIPTNLTI EAYNFDTVLF WNYPIMAQKP VFTVQVKVYG FREDEWLDAC NTSHHHCNIF
SMIKLPDVSL WARVKARLGQ EESAYAESEE FILCQQGKVG PPNLHISHKE DQIIINIFHP
LITVNGKVLG AIYGDETCYT FMYKVHERIN GSLIIDRIFG ENEDDCDETQ CNFSIPVSSL
NSEYCISAEG ISNLRSFKTE MSKELCITIS DSKSIKDSVW IPVVAALLLF LVLILVVVCW
NFKKINPFKR ESIMLPKSLV SVVKNASSEA KAESKYISPV IYEPIVPENE KVIWEEQLSS
AIISSMQTED HPGEVEHGDL SSGTQVGTTE ENTPDMAPGS PLTPVRRGDS VHSGSNQSEP
CIVALNCYHS RNGSDSGLVE SGIFLSDSES PPSNKTGMKT GEPEPITLRN TTTSFGYDKP
HVLVDLPVDE GVKESLIGYR VTADSEEFS
//
