ID G1PC02_MYOLU Unreviewed; 1512 AA.
AC G1PC02;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=RUN and SH3 domain containing 2 {ECO:0000313|Ensembl:ENSMLUP00000007922.2};
GN Name=RUSC2 {ECO:0000313|Ensembl:ENSMLUP00000007922.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000007922.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000007922.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000007922.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02045424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006102779.1; XM_006102717.2.
DR RefSeq; XP_014323526.1; XM_014468040.1.
DR STRING; 59463.ENSMLUP00000007922; -.
DR Ensembl; ENSMLUT00000008692.2; ENSMLUP00000007922.2; ENSMLUG00000008682.2.
DR GeneID; 102429142; -.
DR KEGG; mlf:102429142; -.
DR CTD; 9853; -.
DR eggNOG; ENOG502QR1I; Eukaryota.
DR GeneTree; ENSGT00900000141033; -.
DR HOGENOM; CLU_004141_0_0_1; -.
DR InParanoid; G1PC02; -.
DR OMA; FDHEWKL; -.
DR OrthoDB; 3107370at2759; -.
DR TreeFam; TF332235; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR CDD; cd17702; RUN_RUSC2; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047342; RUN_RUSC2.
DR InterPro; IPR047343; RUSC1_2.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15591:SF14; AP-4 COMPLEX ACCESSORY SUBUNIT RUSC2; 1.
DR PANTHER; PTHR15591; RUN AND SH3 DOMAIN CONTAINING; 1.
DR Pfam; PF02759; RUN; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1029..1173
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 1443..1502
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 41..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1280..1397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1419..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1512 AA; 160974 MW; 3839E4337E98596C CRC64;
MPLFELSRMD SPPKLTGETL IVHHIPLVHC QVPDRQCCGG ASGGSGSTRP NPFCPPELGI
TQPEQDLGQA DSLLYNSLHS APGGSARSAD SSTKSRGRDG RGPGASKRHN PFLLQGSVAE
PGLGDLYDDS IGDSATQQSF HLHGAGQPAF HLSSFQLPPP GPRAGRPWGA TQSRAGVVEG
QEQEPVTTLD PQQCSRNHCC QPELETETME LDECGGPGGS GSGGGASDTS GFSFDQEWKL
SSDESPRNPG CSGSGPQHCR CSSTSSQSEA ADQSMGYVSD SSCNSSDGVL VTFSTLYNKT
HGNSHANLNS APQSCSDSSF CSHSDPGAFY LDLQPSPAES KMSYESHHPD SGEREGSYGC
PHASSPELDA NCNSYRPHCE PCPAVADLTA CFQSQARLVV ATQNYYKLVT CDLSSQSSPS
PAGSSITSCS EEHTKISPVP SSAPDPGPNQ PSEYYLFQKP EAQPEEQVRP MEAEAPTGPT
VIEGQVYTNT SPPNLGTGRQ RSRSYDRSLE RSPPVRLGSL ERMLSCPVRL SEGPTALAGS
SSPPKRVTSF AELAKGRKKA AGSGSPPLRV SVGDSSQDFS PIQEAQQDRA GSLDEGTHCS
HSLPPMPMGP GMDLVGSEPW STQVYQGPQS SEMSPAVLRA SGQGSLMQLM DPGSALPGSP
ANSHTQRDAR ARADGGGAES RPVLRYSKEQ RPTTLPIQPF VFQHHFPKQL AKARALHSLS
QLYSLSGCSR AQQPAPLAPP TAQVPASDPS GEPQASTNRG ARKAGPEPET SRPSPLGSYS
PIRSAGPFGL STDSSASASC SPPPEQATAT ESSPPWSLSC PAVQPATSQQ PQKEDQKILT
LAEYRLHGTG SLPPLGSWRS SLSRAESLAR GGGEGCMASR PNNANHLSPQ ALKWREYRRK
NPLGPPGLSG SLDRRPQEAR LTRRNPIFEF PGSLSAAGHL NCRLNGPMVK PLSLTCPDFQ
DPFSLTEKPP AEFCLSPDGN SEAISIDLLQ KKGLVKAVNT AVDLIVAHFG TSRDPGVKAK
LGNSSVSPNV GHLVLKYLCP AVRAVLEDGL KAFVLDVIIG QRKNMPWSVV EASTQLGPST
KVLHGLYNKV SQFPELTSHT MRFDAFVLGL LNIRSLEFWF NHLYNHEDII QTHYQPWGFL
SAAHTVCPGL FEELLLLLQP LALLPFSLDL LFQHRLLQSG QQQRQHKELL RVSQDLLLSA
HSTLQLARAR SQEGPGDMDS AAHGKRVKGV GAPEGGEDEE EEETEEVTEA AGGSERGRAR
SGQSGWWYQL MQSSQVYIDG STEGSRFPRG GSNSCSGGSS EKKKGAGGGG PPPREGVVEG
AEACPAPEET LGRDRGWPFW MGSPPDSVLA ELRHSREREG SAAPPAESEE GASGPSSGGI
KWGHLFGSRK AQREIRPTNR LPSDWLSLDK SMFQLVAQTV GARREPEPKE SQQEPHAPAL
PSKPPCEVKA LCHHLATGPG QLSFHKGDVL RVLGPAGGDW LRCSRGPDTG LVPLAYVTLT
PTPSPTPGNS QN
//
