ID G1PC22_MYOLU Unreviewed; 1217 AA.
AC G1PC22;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Rap guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSMLUP00000007944.2};
GN Name=RAPGEF1 {ECO:0000313|Ensembl:ENSMLUP00000007944.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000007944.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000007944.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000007944.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02055696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PC22; -.
DR STRING; 59463.ENSMLUP00000007944; -.
DR Ensembl; ENSMLUT00000008718.2; ENSMLUP00000007944.2; ENSMLUG00000008694.2.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000156235; -.
DR HOGENOM; CLU_003982_1_0_1; -.
DR InParanoid; G1PC22; -.
DR OMA; INRQEDF; -.
DR TreeFam; TF317296; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 828..950
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 980..1204
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..288
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1217 AA; 135073 MW; C4B34A1782B00834 CRC64;
DSQRSHLSSF TMKLMDKFHS PKIKRTPSKK GKPADVSVKT LEKPVSKEAT DRFLPEGYPL
PLDLEQQAVE FMSTSAVASR SQRQKNLSRL EEKEKEVVSA LRYFKTIVDK MAIDKKVLEM
LPGSASKVLE AILPLVQSEP CIQHSSALSS CYNRVYQSLA NLIRWSDKVM LEGVNSEDKE
MVTTVKGVIK AVLDGVKELV RLTIEKQGHP SPTSPVKPSS PACKPEGQSE LPLTDREMEI
LNKTTSMSQS TELLPDSTDE EVAPPKPPLP GIRVVDNSPP PALPPKKRQS APSPTRVAVV
APMSRATSGS SLPVGINRQE DFDGDCYAQR RLSGGSHSYG GESPRLSPCS SIGKLSRSDE
QLSSLDRDSG QCSRNTSCET LDHYDPDYEF LQQDLSNADQ IPQQVACNLS PLPEALGESG
SPFLGHPFQL PLGNCPQPDG PSAPGQQTDT PPALPEKKRR SAASQTSDSS GSRVSYERHP
SQYDNICEDD LQNPALVQPA PFTPFAAILP FQQGGSSASV DFVSDFTAPE SAGDPEKPPP
LPEKKNKHML AYMQLLEDYS EPQPSMFYQT PQNEHVYQQK NKMLMEVYGF NDSFSSADPP
DLAPPPALPP KQRQLQASYA ASSFSSVSYC VQQTKVAFTP EDGSATQGIS VSVSNSFLSR
HGNLPVPSYK SVFRSYSQDF VPHSQASAQP FLPSTSSSSP HFPPVHQSQS SDLARPAPAT
LPPSAADGPP PSSQESTFHG STVCLPSETS LPASPQTPSE SPAVRDGHPR DPSSVGNAPG
KESRDGERAL KSPDGPESAQ SEEEVDELSL IDHSEIMARL TLKQEGDDGP DVRGGSGDIL
LVHATETDRK DLVLYCEAFL TTYRTFITPE ELIKKLQYRY EKFSPFADTF KKRVSKNTFF
VLVRVVDELC LVELTEEILK LLMELVFRLV CNGELSLARV LRKNILDKVD QKKLLRCAHS
DQPLAARGVA ARPGTLHDFH SHEIAEQLTL LDAELFYKIE IPEVLLWAKE QNEEKSPNLT
QFTEHFNNMS YWVRSIIMLQ EKAQDRERLL LKFIKIMKHL RKLNNFNSYL AILSALDSAP
IRRLELHAPP AQGLAEYCTL IDSSSSFRAY RAALSEVEPP CIPYLGLILQ DLTFVHLGNP
DYIDGKVNFS KRWQQFNILD SMRCFQQAHY DIRRNDDIIN FFNDFSDHLA EEALWELSLK
IKPRNITRRK TDREEKT
//
